Defrol 20000 IU Capsule 10's

✔️ Uses of Defrol 20000 IU Capsule

Rickets, osteomalacia, osteoporosis, preeclampsia, prediabetes.

✔️ Special Consideration:

• Chewable or dissolving capsules may contain sugar or aspartame, so caution is needed in diabetes and phenylketonuria (increased levels of an amino acid called phenylalanine).
• Pregnant or breastfeeding women should consult their physician before taking Defrol 20000 IU Capsule. Higher doses in pregnant women should be used only when advised by the doctor.
• Defrol 20000 IU Capsule passes into breast milk, so breastfeeding mothers should seek medical advice before starting the medication.
• Safe for use in children when recommended by the pediatrician.
• Use with caution in hypercalcemia, renal impairment, heart diseases, kidney stones, and hypervitaminosis D (having too much vitamin D).

✔️ How does Defrol 20000 IU Capsule work?

Defrol 20000 IU Capsule 10's contains 'Cholecalciferol' is a form of vitamin D. Cholecalciferol (vitamin D3) supplement acts by promoting the absorption of calcium, phosphates, and Vitamin A from different organs and helps in maintaining overall health.

✔️ Side Effects of Defrol 20000 IU Capsule

• Common: Acute symptoms like anorexia, lassitude, nausea, vomiting, diarrhea, constipation, weight loss, polyuria, sweating, headache, thirst, vertigo, and raised concentrations of calcium and phosphate in plasma and urine.
• Rare: Dry mouth, headache, weakness, lack of energy.

✔️ Quick Suggestions:

• Helps in building strong bones and teeth
• Aids in reducing fatigue, stress, and muscle pain
• Boosts immunity and improves the body’s resistance to infections
• Beneficial for patients with diabetes and cardiovascular conditions

✔️ Indications:

Vitamin D deficiency:

• Cause: Inadequate intake of Vitamin D through food or insufficient exposure to sunlight, which is essential for the synthesis of Vitamin D in the skin.
• Consequence: Can lead to thin, brittle, or misshapen bones due to a lack of calcium absorption.

Osteoporosis:

• Description: A bone disease characterized by weakened and brittle bones, often resulting from a decrease in bone density.
• Cause: Loss of bone mass and structural deterioration, making bones more susceptible to fractures.

Tetany:

• Description: A condition caused by low levels of calcium (hypocalcemia) in the body.
• Symptoms: Cramps and spasms, particularly in the hands, feet, and larynx (voice box).

Osteomalacia/Rickets:

• Osteomalacia: Softening and weakening of bones in adults due to a deficiency of Vitamin D or problems with its metabolism.
• Rickets: Similar to osteomalacia but occurs in children, leading to soft and weakened bones as they are still growing.

Hypoparathyroidism:

• Description: Characterized by low levels of parathyroid hormone.
• Consequence: Low parathyroid hormone levels can result in low calcium levels, leading to symptoms such as muscle cramps, spasms, or tremors.

✔️ Pharmacology

Vitamin D3 is absorbed, metabolized in the liver, and further converted to its active form (calcitriol) in the kidney. Calcitriol enhances calcium absorption. Non-metabolized Vitamin D3 is stored in tissues. Elimination occurs through feces and urine.

✔️ Dosage & Administration:

• Capsule  20000 IU (Adults):
  • Treatment: 40,000 IU/week for 7 weeks, then maintenance (1400-2000 IU/day).
  • Prevention: 20,000 IU/month.
• Capsule  20000 IU (Children 12-18 years):
  • Treatment: 20,000 IU once every 2 weeks for 6 weeks.
  • Prevention: 20,000 IU once every 6 weeks.

✔️ Interaction

• With medicine: Interactions with antacids, phenytoin, phenobarbital, cholestyramine, colestipol, digoxin, thiazide diuretics, and others.
• With food & others: Avoid alcohol or tobacco consumption while taking vitamin D3.

✔️ Contraindications

Hypercalcemia-associated diseases, hypersensitivity, severe renal impairment, hypervitaminosis D, nephrolithiasis.

✔️ Pregnancy & Lactation

• Increased Vitamin D3 needs during pregnancy.
• Assumed passage into breast milk; monitor serum calcium levels.

✔️ Precautions & Warnings

• Monitor plasma-calcium concentrations during high-dose therapy, pregnancy & lactation.
• Caution with digoxin and thiazide diuretics.
• Consult healthcare practitioners in certain conditions (liver or kidney disease, hyperthyroidism, lymphoma, tuberculosis, granulomatous disease).

✔️ Storage Conditions

• Below 30°C, dry place, protected from light. Keep out of reach of children.