Marincal-DX Tablet

✔️ Uses of Marincal-DX Tablet

• Calcium and vitamin D deficiency,
• Calcium and vitamin D supplements
• Osteoporosis.

✔️ How does Marincal-DX Tablet work?

Calcium and vitamin D3 help prevent or treat negative calcium balance: Calcium is essential for maintaining proper calcium levels in the body. Vitamin D3 aids in the regulation of calcium and phosphate balance, ensuring that calcium is properly absorbed and utilized.

Nerve and muscle performance: Calcium is involved in nerve transmission and muscle contraction, playing a crucial role in facilitating their proper function. Adequate levels of calcium and vitamin D3 support optimal nerve and muscle performance.

Cardiac function: Calcium is necessary for normal cardiac function, as it plays a role in regulating the contraction and relaxation of the heart muscles.

Bone mineralization and formation: Calcium is a vital component of bones, and it contributes to their strength and density. Vitamin D3 aids in the absorption of calcium from the gastrointestinal tract and stimulates bone formation. Together, calcium and vitamin D3 have synergistic effects on bone growth and help prevent conditions like osteoporosis and fractures.

✔️ Side Effects of Marincal-DX Tablet

• Calcium Anorexia
• Constipation
• Flatulence
• Nausea
• Vomiting
• Hypercalcemia
• Hypophosphatemia
• Xerostomia,
• Milk-alkali syndrome
• bone and muscle aches
• a metallic flavor
• Headache
• Nausea
• Vomiting
• a dry mouth
• Constipation
• Arrhythmias

✔️ Quick Suggestions:

• Multimineral Nutritional Supplement: HealthKart HK Vitals Calcium Tablets include not only calcium but also magnesium, zinc, Vitamin D3, and Cissus Quadrangularis to enhance bone strength, muscle strength, and joint health
• Highly Absorbable Calcium: Calcium Citrate Malate (CCM) in HK Vitals Calcium Supplement (from the house of HealthKart) is an easily absorbable and highly bioavailable form of calcium. Vitamin D helps the body absorb calcium better and reduces the rate of loss of bone density (osteoporosis)
• Enhances Bone & Joint Health: Calcium with Vitamin D3 in these calcium tablets for women and men is required for the maintenance of bones and joints. Cissus and Vitamin D3 help improve joint health by improving cartilage synthesis and preventing articular cartilage degeneration
• Muscle Strength: Calcium helps in muscle contraction and muscle building. HK Vitals Calcium Tablets also include Zinc which assists in muscle protein synthesis, a process by which consumed protein becomes muscle

✔️ Indication of Marincal-DX Tablet

This medication is used to treat and prevent osteoporosis, osteomalacia, tetany, hypoparathyroidism, and osteogenesis disorders. Also used as a supplement in cases of insufficient calcium intake in childhood nutrition, rickets, pregnancy and lactation, and geriatric people. Other uses include pancreatitis, phosphate binder in chronic renal failure, and so on.

✔️ Pharmacology

This is a calcium and vitamin D3 supplement in which calcium carbonate is derived from coral. The chemical structure of coral calcium carbonate is remarkably similar to the composition of human bone. Coral calcium is similar to other sources, however, it is more absorbable. Vitamin D3 promotes calcium absorption from the GI tract and helps to maintain calcium homeostasis in the body.

✔️ Dosage & Administrations of Marincal-DX Tablet

One tablet once or twice daily with plenty of water or as directed by the physician. Taking in a full stomach ensures better absorption.

✔️ Interaction

• Tetracycline: Calcium can interfere with the absorption of tetracycline antibiotics. It's generally recommended to separate the doses of calcium supplements and tetracycline by at least 2 hours to minimize this interaction and ensure optimal absorption of both medications.
• Systemic corticosteroids: Concurrent use of systemic corticosteroids may reduce calcium absorption. This interaction can potentially lead to decreased effectiveness of calcium supplementation. Monitoring calcium levels and adjusting the dosage accordingly may be necessary for individuals using corticosteroids.
• Thiazide diuretics: Thiazide diuretics can decrease urinary excretion of calcium, potentially leading to increased levels of calcium in the body. This interaction may necessitate monitoring of calcium levels and adjustment of calcium supplementation if needed.
• Ion-exchange resins: Concurrent use of ion-exchange resins, such as cholestyramine or colestipol, can reduce the gastrointestinal absorption of vitamin D. It is generally recommended to separate the doses of vitamin D supplements and ion-exchange resins by at least 2 hours to minimize this interaction.
• Hypercalcemia and cardiac glycosides: Hypercalcemia, an excessive level of calcium in the blood, can increase the toxicity of cardiac glycosides. It's important to monitor electrocardiogram (ECG) and serum calcium levels closely during treatment with calcium and vitamin D, particularly in individuals receiving cardiac glycosides.
• Bisphosphonates or sodium fluoride: Bisphosphonates or sodium fluoride, medications used for bone health, should be administered at least 3 hours before taking calcium-containing preparations. This interval helps to minimize any potential interference between these medications and ensure their optimal effectiveness.

✔️ Contraindications

Hypersensitivity to any of the components, hypocalcemia caused by a vitamin D3 excess, hyperparathyroidism, bone metastases, severe renal insufficiency, severe hypercalciuria, renal calculi, and so on.

✔️ Pregnancy & Lactation

While calcium and vitamin D are generally considered safe for pregnant women at recommended doses, it's crucial to adhere to the specific guidelines and avoid excessive intake. Here are some key points to consider:

Calcium intake: During pregnancy, the recommended daily dose of calcium typically ranges from 1000 to 1300 mg. It's generally safe to consume up to 1500 mg of calcium per day, but exceeding this limit should be avoided to prevent potential complications.

Vitamin D intake: The recommended daily dose of vitamin D during pregnancy is usually around 600 to 800 IU (International Units). Vitamin D supplementation within this range is considered safe and beneficial. However, it's important not to exceed the recommended dose, as excessive vitamin D intake can have negative effects.

Potential risks of excessive intake: Animal studies have indicated that high doses of vitamin D can have toxic effects on reproduction. Prolonged hypercalcemia (high levels of calcium in the blood) during pregnancy has been associated with developmental issues, such as physical and mental retardation, supra valvular aortic stenosis, and retinopathy in the child. Therefore, it's crucial to avoid overdosing on calcium and vitamin D during pregnancy.

Teratogenic effects: There is currently no evidence to suggest that therapeutic doses of vitamin D3 are teratogenic (causing birth defects) in humans.

It's always recommended to consult with a healthcare professional or your prenatal care provider before starting any new supplements during pregnancy. They can provide personalized guidance based on your specific needs and ensure that you are following the appropriate dosage and safety guidelines.

✔️ Precautions & Warnings

• Hypercalcemia and discontinuation of the drug: If hypercalcemia occurs due to excessive calcium supplementation, discontinuing the supplement is typically enough to restore normal serum calcium levels. It's essential to monitor calcium levels regularly during supplementation to avoid excessive intake.
• Caution in certain medical conditions: Calcium salts should be used with caution in patients with conditions such as sarcoidosis, renal disease, cardiac disease, and those receiving cardiac glycosides. These conditions may be associated with altered calcium metabolism or increased susceptibility to adverse effects.
• History of stone formation: Patients with a history of stone formation should be advised to increase fluid intake. Sufficient hydration helps promote urine dilution and reduce the risk of stone formation.
• Calcium and vitamin D during pregnancy and lactation: Adequate intake of calcium and vitamin D is important during pregnancy and lactation to support the development of the fetus and the nutritional needs of the mother. It is generally recommended to follow the recommended daily allowances for calcium and vitamin D during this period.

✔️ Storage Conditions

Do not store above 30° C. Keep away from light and out of the reach of children.