Dapgel 7.50% Gel

✔️ Uses of Dapgel 7.50% Gel

• Treats Acne

✔️ How does Dapgel 7.50% Gel work?

Dapgel 7.50% Gel serves a dual purpose in treating acne vulgaris by acting as both an antibacterial and anti-inflammatory agent. It hinders bacterial growth by blocking folic acid synthesis, essential for bacterial multiplication. Simultaneously, it reduces inflammation, promoting the healing of acne breakouts.

✔️ Side Effects of Dapgel 7.50% Gel

• Skin irritation
• Redness of the skin
• Burning or stinging sensation at the application site
• Dry skin
• Skin peeling

✔️ Quick Suggestions:

• Dapsone is used in the treatment of leprosy.
• It may also help with the treatment of acne when used as a gel
• Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
• Take it in the dose and duration as prescribed by your doctor.
• Inform your doctor if your condition does not improve or if becomes worse.

✔️ Indication

Acne vulgaris is a prevalent skin issue resulting from hair follicles getting clogged by oil and dead skin cells. This leads to blackheads, whiteheads, and pimples. Dapgel 7.50% Gel clears these blockages, reducing acne breakouts.

✔️ Pharmacology

Dapsone possesses both anti-inflammatory and antimicrobial properties, contributing to its effectiveness against acne. It curbs inflammation by inhibiting activities of neutrophil myeloperoxidase and eosinophil peroxidase, reducing hypochlorous acid production, scavenging reactive oxygen species, suppressing neutrophil activity, and blocking chemoattractant-induced signal transmission. In terms of its antimicrobial effects, similar to sulfones and sulfonamides, it operates by inhibiting bacterial dihydropteroate synthase in the folic acid metabolic pathway. This mechanism is particularly potent against microorganisms that produce their own folic acid. In laboratory testing, Dapsone has shown some efficacy against Propionibacterium species, including Propionibacterium acnes (P. acnes).

✔️ Dosage & Administration of Dapgel 7.50% Gel

Before and after using Dapsone, make sure to wash your hands. Apply a thin layer of the gel to the clean, dry affected skin area as instructed by your doctor. Remember, this gel is meant for external use only. Avoid getting the gel in contact with your mouth, eyes, or vagina, as it might lead to irritation. If accidental contact occurs, thoroughly rinse the area with water.

✔️ Interaction

Before using Dapgel 7.50% Gel, it's important to inform your doctor if you are taking any of the following medications:

• Trimethoprim/sulfamethoxazole, nitrofurantoin (used for urinary tract treatment and prevention)
• Topical benzoyl peroxide (used to treat acne)
• Sulphonamides like sulfadiazine, and sulfamethizole (for bacterial infections)
• Acetaminophen, acetanilide (pain relief)
• Nitroprusside, nitrates, and nitrites like glyceryl trinitrate (angina treatment)
• Benzocaine (pain relief)
• Oral dapsone (for leprosy, dermatitis herpetiformis)
• Pamaquine, chloroquine, para-amino salicylic acid, quinine (malaria treatment and prevention)
• Phenacetin (fever treatment)
• Phenobarbital, phenytoin (for seizures)

If you have glucose 6-phosphate dehydrogenase (G6PD) deficiency or methemoglobinemia (blood disorder), please inform your doctor before using Dapsone.

In case of overdose:

Dapgel 7.50% Gel is meant for topical use only and should not be ingested orally. If accidental ingestion occurs, promptly consult your doctor or seek medical attention at a nearby hospital.

✔️ Contraindications

Hypersensitivity and severe anemia are contraindications for using this medication. Additionally, individuals with porphyria should also avoid its use.

✔️ Pregnancy & Lactation

Dapsone is classified as Pregnancy Category C, indicating that there is a lack of sufficient and well-controlled studies involving pregnant women. Its use during pregnancy should only be considered if the potential benefits outweigh the potential risks to the fetus.

When it comes to nursing mothers, while the absorption of Dapsone through topical application is minimal compared to oral administration, Dapsone has been found to be excreted in human milk. Since there's a possibility of adverse reactions in nursing infants due to oral Dapsone, a decision should be made after considering whether to discontinue nursing or the use of Dapsone, taking into account the drug's importance to the mother.

✔️ Precautions & Warnings

• If you have an allergy to Dapsone or any other medications, it's important to inform your doctor. Methemoglobinemia, a condition characterized by elevated levels of methemoglobin in the blood, should also be communicated to your doctor before using Dapsone.
• Avoid allowing the topical form of Dapsone to come into contact with your mouth, eyes, or vagina. If accidental contact occurs, thoroughly rinse with water.
• If you're pregnant or breastfeeding, it's advised to consult a doctor before using this medication.
• Follow the prescribed dosage and duration of Dapsone. Using larger amounts or extending usage beyond what's prescribed can increase the risk of side effects without yielding faster or better results.
• In case you experience symptoms like shortness of breath, weakness, back pain, tiredness, dark brown urine, fever, and pale or yellow skin, stop using Dapsone and promptly consult a doctor. These could be signs of hemolytic anemia (breakdown of red blood cells), a condition that can occur in individuals with glucose 6-phosphate dehydrogenase (G6PD) deficiency using Dapsone.

✔️ Storage Conditions

Store in a cool & dry place. Keep out of reach of children. Do not freeze.