Filin IV Injection 1pc

Uses of Filin IV Injection

• Asthma
• Chronic obstructive pulmonary disease (COPD)

How does Filin IV Injection work?

It works by relaxing the muscles of the airways and widening the airways. This makes breathing easier.

Side Effects of Filin IV Injection

Common side effects include gastric irritation, nausea, vomiting, diarrhea, hematemesis, epigastric pain, and tremor. High doses may lead to ventricular arrhythmias or seizures, reactivation of peptic ulcers, headache, irritability, restlessness, insomnia, twitching, convulsions, reflex hyperexcitability, palpitations, tachycardia, hypotension, circulatory failure, ventricular arrhythmias, flushing, albuminuria, diuresis, hematuria, and inappropriate ADH syndrome.

Quick Suggestions:

• You have been prescribed Aminophylline for the prevention and treatment of asthma and chronic obstructive pulmonary disease (COPD).
• It should be taken at the same time each day, preferably in the evening after food.
• It does not work right away and should not be used to relieve sudden breathing problems. Always keep a fast-acting (rescue) inhaler with you.
• Your doctor may take regular blood tests to monitor potassium levels and the level of this medicine in your body.
• Notify your doctor if you have ever been diagnosed with kidney, liver, or heart disease, or if you have a smoking history. Your dose may need to be adjusted.
• Do not discontinue use without consulting your doctor, even if you feel better.

Indication of Filin IV Injection

Aminophylline is indicated for the treatment and prophylaxis of bronchospasm associated with asthma, emphysema, and chronic bronchitis. It is also used in adults for treating cardiac asthma and left ventricular or congestive cardiac failure.

Pharmacology

Aminophylline is a combination of theophylline and ethylenediamine. Ethylenediamine increases the solubility of theophylline in water. Theophylline relaxes bronchial smooth muscle by increasing intracellular cAMP through inhibition of phosphodiesterase, antagonizing adenosine receptors, antagonizing prostaglandins, and affecting intracellular calcium.

Dosage & Administration of Filin IV Injection

• Adults: Loading dose of 5 mg/kg (ideal body weight) or 250-500 mg (25 mg/ml) by slow injection or infusion over 20-30 minutes. The maintenance infusion dose is 0.5 mg/kg/hr with a maximum rate of 25 mg/min.
• Children: Same loading dose as adults. The maintenance dose is 1 mg/kg/hr for ages 6 months-9 years and 0.8 mg/kg/hr for ages 10-16 years.
• Elderly and those with hepatic impairment: Dose reduction may be necessary.

Drug-Drug Interactions

Aminophylline may interact with various medications, including:

• Heartburn or ulcer treatments: such as cimetidine.
• Antibiotics: like erythromycin and ciprofloxacin.
• Antifungal medications: such as fluconazole.
• Gout treatments: like allopurinol and sulphinpyrazone.
• Blood pressure or chest pain medications: such as diltiazem and propranolol.
• Antidepressants: like fluvoxamine.
• Epilepsy medications: including phenytoin and carbamazepine.
• Diuretics: like furosemide.
• Heart-related medications: such as isoprenaline and digoxin.
• Anthelmintics: like thiabendazole.
• Corticosteroids: such as prednisone.
• Oral contraceptives: like ethinylestradiol.
• Antimanic agents: such as lithium.
• Anticancer drugs: including interferon alfa and methotrexate.
• Stroke risk reducers: like ticlopidine.

Drug-Food Interactions

Avoid alcohol consumption while taking Aminophylline as it may increase drowsiness. Additionally, avoid St. John’s Wort (an antidepressant) and caffeine-containing foods or drinks, as they can interfere with Aminophylline's effectiveness.

Drug-Disease Interactions

Aminophylline should be used with caution if you have any of the following conditions:

• Heart problems
• Overactive thyroid gland (hyperthyroidism)
• Stomach ulcer
• Liver problems
• Seizures (fits) or convulsions
• Fever
• Viral infection
• Alcoholism
• Male patients with difficulty passing urine (due to an enlarged prostate gland)

Contraindications

Aminophylline should not be used in patients with hypersensitivity to xanthines or ethylenediamine, or in those with active peptic ulcers, as it may increase the volume and acidity of gastric secretions.

Pregnancy & Lactation

The use of aminophylline in pregnant women should be balanced against the risk of uncontrolled disease. Always consult a doctor before using aminophylline during pregnancy or lactation.

Precautions & Warnings

Aminophylline should be used with caution in patients with peptic ulceration, hyperthyroidism, hypertension, cardiac arrhythmias, other cardiovascular diseases, epilepsy, heart failure, hepatic dysfunction, chronic alcoholism, acute febrile illness, and in neonates and the elderly. These conditions may decrease theophylline clearance, leading to increased serum-theophylline concentrations and serum half-life.

Storage Conditions:

Store in a cool and dry place away from sunlight