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Leukeran
Chlorambucil is indicated in the treatment of Hodgkin's disease, certain forms of non-Hodgkin's lymphoma, chronic lymphocytic leukemia, and Waldenstrom macroglobulinemia.
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✅ Description:
Leukeran is prescribed for various blood and lymphatic system cancers, sometimes in combination with other cancer medications, as determined by the physician. It's crucial to take Leukeran on an empty stomach, or 1 hour before and 2 hours after a meal, preferably at the same time daily for optimal results. Follow your doctor's instructions precisely to avoid serious side effects. While it may take some time to observe the benefits, do not discontinue unless advised by your doctor.
Leukeran can lower blood cell counts, increasing infection risk. Regular blood tests to monitor blood cells, kidney, liver, and heart function are necessary during treatment. Effective contraception is crucial for both males and females to prevent pregnancy during treatment with Leukeran.
Safety Advices
Alcohol
UNSAFE
It is not known whether it is safe to consume alcohol with Leukeran. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Chlorambucil is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
Breastfeeding
CONSULT YOUR DOCTOR
Chlorambucil is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
Driving
CAUTION
It is not known whether Leukeran alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney
CONSULT YOUR DOCTOR
Chlorambucil should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Liver
CONSULT YOUR DOCTOR
Chlorambucil should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
✔️ Uses of Chlorambucil
- Hodgkin's Lymphoma
- Chronic Lymphocytic Leukaemia
- Waldenstrom Macroglobulinemia
- Non-Hodgkin's Lymphoma
✔️ How does Chlorambucil work?
Chlorambucil interferes with DNA replication and damages DNA in cells. This DNA damage induces cell cycle arrest and cellular apoptosis, ultimately leading to the death of cancer cells.
✔️ Side Effects:
Common side effects include bone marrow suppression, nausea, vomiting, diarrhea, and oral ulceration. Rare side effects may include irreversible bone marrow failure, allergic reactions, Stevens-Johnson syndrome, seizures, and hepatotoxicity.
✔️ Administration :
Leukeran Tablet should be taken on an empty stomach, ensuring adequate hydration. It should be swallowed whole without chewing or crushing.
✔️ Dosage
The dosage varies based on the condition being treated:
- Hodgkin's disease: 200 mcg/kg/day for 4-8 weeks.
- Non-Hodgkin's lymphoma: 100-200 mcg/kg/day for 4-8 weeks.
- Chronic lymphocytic leukemia: Initially, 150 mcg/kg/day until the total leukocyte count falls to 10,000 microliters, then resumed at 100 mcg/kg/day.
- Waldenstrom's macroglobulinemia: Starting dose of 6-12 mg daily until leucopenia occurs, followed by 2-8 mg daily.
✔️ Pregnancy & Lactation
Leukeran Tablet is contraindicated during the first trimester of pregnancy and lactation due to the potential risks to the fetus or infant. However, in certain life-threatening situations, the benefits may outweigh the risks.
✔️ Precautions & Warnings
Close monitoring of full blood count (FBC) is recommended, and bone marrow suppression is reversible if treatment is stopped early. Caution is advised in patients with renal or hepatic impairment, seizure disorders, and those undergoing high pulse dosing regimens. Adequate contraceptive precautions should be ensured during treatment.
✔️ Storage Conditions
- Keep Leukeran Tablet out of reach of children
- Store below 25°C
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