Tamiren 20mg Tablet 10pcs

✔️ Uses of Tamiren 20

• Treatment of breast cancer.
• Reducing the risk of breast cancer in women with a high likelihood of developing it.
• Treatment of infertility.

✔️ How Tamiren Works

Tamiren is an anti-estrogen medication.

• It binds to estrogen receptors, blocking the effects of estrogen in breast tissue.
• This action slows down the growth and multiplication of cancer cells.

✔️ How to Take Tamiren

• Take this medicine exactly as prescribed by your doctor.
• Swallow the tablet whole with water.
• Can be taken with or without food, but try to take it at the same time each day.
• Follow the full course as advised by your doctor.

✔️ Adult Dose Guidelines for Tamoxifen

Breast Cancer Treatment

• Standard Dose: 20 mg daily as a single dose or in two divided doses.
• Maximum Dose: 40 mg daily.
• Duration:
  • For adjuvant therapy, continue for at least 5 years.
  • For women with ER-positive breast cancer, extending therapy to 10 years provides a further reduction in recurrence and mortality, especially after year 10.

Breast Cancer Prevention

• Indication: To reduce the incidence of breast cancer in women at high risk, defined as:
  • Age >35 years with a 5-year predicted breast cancer risk >1.67% (calculated using the Gail Model).
• Dose: 20 mg daily for 5 years.
• Note: Limited data is available for use beyond 5 years in a risk-reduction setting.

Anovulatory Infertility

• Standard Dose: 20 mg daily on days 2-5 of the menstrual cycle.
• Dose Adjustment: Increase dose in subsequent cycles if necessary.
  • Maximum Dose: 80 mg daily.
• For Women with Irregular Menstruation:
  • Begin the first course on any day.
  • Start the second course 45 days later, or on day 2 of the cycle if menstruation occurs.

✔️ Common Side Effects

Mild Side Effects:

• Nausea
• Skin rash
• Hot flushes
• Thinning of hair
• Vaginal discharge
• Swelling

Serious Side Effects:

• Vaginal bleeding
• Irregular menstrual periods
• Severe vaginal discharge

✔️ Interaction

Dopaminergic Effect:

• Bromocriptine: Tamoxifen increases the dopaminergic effect of bromocriptine.

Risk of Thromboembolic Events:

• Cytotoxic Drugs: Concomitant use increases the risk of thromboembolic events (e.g., deep vein thrombosis or pulmonary embolism).

Risk of Bleeding:

• Platelet Aggregation Inhibitors: Combined use may increase the risk of bleeding.

Hormone Preparations:

• Estrogens (e.g., oral contraceptives): There may be a mutual reduction in effects when used together with tamoxifen.

Drug Metabolism (CYP Enzyme Interactions):

• CYP3A4 Inducers (e.g., rifampicin): Reduced plasma levels of tamoxifen, potentially reducing its efficacy.
• CYP2D6 Inhibitors: Also reduces plasma levels of tamoxifen, diminishing its therapeutic effects.
• CYP3A4 Inhibitors: Increased plasma levels of tamoxifen, potentially increasing the risk of side effects.

Potentially Fatal Interaction:

• Coumarin-type Anticoagulants (e.g., warfarin): Significant increase in anticoagulant effect, which can lead to severe or fatal bleeding complications. Careful monitoring and dose adjustments are critical if co-administered.

✔️ Inform Your Doctor If:

• You are pregnant, planning to conceive, or breastfeeding.
• You are undergoing infertility treatment.
• You have a history of blood clot disorders.

✔️ Pregnancy Prevention:

• Tamiren can reduce the effectiveness of birth control pills. Use reliable barrier contraceptives (e.g., condoms) while taking it and for 2 months after stopping the medication.
• Your doctor may recommend blood tests to monitor liver function and calcium levels.

✔️ Contraindications:

• History of Deep Vein Thrombosis (DVT) or pulmonary embolism.
• Should not be used during pregnancy due to potential harm to the fetus.
• Avoid use as it is unclear if the drug passes into breast milk.
• Concomitant use with coumarin-type anticoagulant therapy is contraindicated.

✔️ Storage:

Store between 20-25° C. Protect from light.