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Tamona 20mg Tablet 10pcs
Tamoxifen 20mg
- Treatment of Breast Cancer
- Management of Anovulatory Infertility
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✅ Description:
Tamoxifen (Tamona) is a non-steroidal, triphenylene-based medication with both estrogen antagonists and agonist effects, depending on the tissue.
- The mechanism in Breast Cancer: Acts as an antioestrogen at the tumor site by blocking estrogen receptors, thereby inhibiting tumor growth.
- Bone Health: Maintains bone mineral density in postmenopausal women due to its estrogen agonist-like activity on bones.
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✔️ Dosage & Administration of Tamona 20
- Breast Cancer: 20 mg daily.
- Anovulatory Infertility:
- 20 mg daily on days 2-5 of the menstrual cycle.
- The dose may increase to 40 mg or 80 mg in subsequent cycles if needed.
- For irregular cycles, start the first course on any day, with subsequent courses 45 days later or on day 2 if menstruation occurs.
Always follow a registered physician's advice for dosage.
✔️ Side Effects of Tamona 20
Common:
- Hot flushes
- Vaginal bleeding or discharge
- Pruritus vulvae
- Tumor flare
- Gastrointestinal disturbances (nausea, vomiting, diarrhea)
- Fluid retention
- Headache
Less Common/Severe:
- Dermatological: Skin rashes (e.g., erythema multiforme, Stevens-Johnson syndrome).
- Blood: Leucopenia, thrombocytopenia, or neutropenia (occasionally severe).
- Visual: Corneal changes, retinopathy, cataracts.
- Reproductive: Uterine fibroids, endometrial hyperplasia, cystic ovarian swelling.
- Thromboembolic Events: Deep vein thrombosis, pulmonary embolism.
- Liver: Elevated liver enzymes, fatty liver, cholestasis, hepatitis.
- Metabolism: Elevated triglyceride levels (rarely leading to pancreatitis).
✔️ Interactions
- Anticoagulants: Co-administration with coumarin-type anticoagulants may increase their effects. Close monitoring is recommended.
- With Cytotoxic Agents: Combined use may heighten the risk of thromboembolic events.
✔️ Contraindications
- Pregnancy: Tamona must not be used due to potential risks to the fetus, including birth defects and fetal death.
- Allergic Reactions: Avoid use in individuals with hypersensitivity to Tamoxifen or its components.
✔️ Pregnancy & Lactation
- Pregnancy: Contraindicated. May cause harm to the fetus.
- Lactation: Not recommended, as it is unknown if Tamoxifen is excreted in human milk.
✔️ Precautions & Warnings
- Common in premenopausal women undergoing breast cancer treatment.
- Increased risk due to the estrogen-like effect of Tamona. Any abnormal gynecological symptoms, especially vaginal bleeding, should be promptly investigated.
- Second Primary Tumors is Rare but reported. The clinical relevance is unclear.
- Women must use barrier or nonhormonal contraceptives during treatment and for two months after stopping the medication.
✔️ Storage
- Store at 20-25°C.
- Protect from light.
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