Lithosun SR 400mg 10pcs

Uses of Lithosun SR Tablet

• Used to manage depression

How does Lithosun SR Tablet work?

Side Effects of Lithosun SR Tablet

Common side effects include:

• Tiredness
• Loss of appetite
• Nausea, vomiting
• Diarrhea
• Tremors (shaking hands)
• Memory issues
• Increased thirst and frequent urination

Quick Suggestions:

• Lithium carbonate is one of the most effective long-term treatments for bipolar disorder.
• It may also be used for the treatment of mania.
• Your lithium blood levels, thyroid function, and kidney function may be monitored as long as you take this medicine.
• It may cause diarrhea and dehydration. Drink plenty of water and use normal amounts of salt. Inform your doctor if you start or stop a low-salt diet.
• Monitor your weight during treatment as Lithium carbonate can cause weight gain.
• Do not drive or do anything that requires mental focus until you know how it affects you.
• Inform your doctor if you have persistent stomach upset, problems with your speech, or extreme drowsiness. Your dose may need to be adjusted.
• Do not take Lithium carbonate if you are pregnant or breastfeeding.
• Do not stop taking the medication suddenly without talking to your doctor.

Overdose Effects of Lithosun SR Tablet

In case of lithium overdose:

• Discontinue lithium immediately.
• Serum lithium levels should be monitored every six hours.
• Avoid using diuretics.
• Osmotic diuresis (mannitol or urea infusion) or alkalinization (sodium lactate or bicarbonate infusion) should be initiated.
• If serum lithium exceeds 4.0 mmol/L or the patient's condition worsens, prompt dialysis (peritoneal or hemodialysis) should be performed until lithium is cleared from serum or dialysis fluid. Continue monitoring for at least one week to address any rebound in serum lithium levels.

Pharmacology

Lithium's mechanism of action in treating bipolar disorder remains unclear despite over 50 years of clinical use. It is thought to work by inhibiting enzymes such as glycogen synthase kinase 3 and inositol phosphatases, or by modulating glutamate receptors. Lithium carbonate also affects the intraneuronal metabolism of catecholamines and alters sodium transport in neurons and muscle cells.

Dosage & Administration of Lithosun SR Tablet

• Adults and children over 12 years: Initial dose of 1 gm to 1.5 gm daily.
• Prophylaxis: Initial dose of 300-400 mg daily.
• Should be taken with food.
  (Always follow the prescription of a registered physician.)

Renal Impairment: For patients with CrCl between 10-50 mL/min, 50-75% of the normal dose should be administered.

Interaction

• Reduced serum levels: Carbonic anhydrase inhibitors, chlorpromazine, sodium preparations, theophylline, urea.
• Enhanced hypothyroid effects: Iodine salts.
• Increased effects: Neuromuscular-blocking agents.
• Reduced pressor response: Sympathomimetics.

Contraindications

Lithium therapy is contraindicated in:

• Renal insufficiency
• Cardiovascular insufficiency
• Addison's disease
• Untreated hypothyroidism

Pregnancy & Lactation

• Pregnancy Category D: Lithium is associated with an increased risk of cardiovascular abnormalities in infants when taken during the first trimester. Avoid use unless necessary.
• Breastfeeding: Not recommended unless the benefits outweigh the risks.

Precautions & Warnings

Patients with excessive sweating or diarrhea may experience reduced lithium tolerance. Supplemental fluids and salt may be needed under medical supervision and lithium intake should be adjusted or temporarily discontinued until the condition stabilizes.

Storage:

Store at 25°C.