Zybex SR 150mg (10pcs)

✔️ Uses of Zybex SR 150

• Depression
• Smoking Addiction

✔️ How does Zybex SR 150 work?

Increases chemical messengers in the brain, regulating mood. The mechanism for smoking addiction is not fully understood.

✔️ Side Effects of Zybex SR 150

• Common: Headache, dry mouth, nausea, insomnia, agitation, dizziness, and more.
• Immediate side effects often resolve over time. Consult your doctor if persistent.

✔️ Quick Suggestions:

• Used for depression and smoking cessation.
• Better taken in the morning to avoid sleep difficulties.
• Causes fewer side effects compared to other antidepressants.
• Report sudden mood changes or suicidal thoughts to your doctor.

✔️ Missed Dose:

• If you miss a dose, skip it and continue with the regular schedule. Do not double the dose.

✔️ Indications of Zybex SR 150

• Treats major depressive disorder
• Prevents seasonal affective disorder in affected individuals

✔️ Depression

Depression is a mood disorder characterized by persistent feelings of sadness, hopelessness, and a lack of interest or pleasure in daily activities. It can significantly impact a person's emotional and physical well-being.

Key Features of Depression:

1. Mood Symptoms: Prolonged feelings of sadness, emptiness, or irritability.
2. Physical Symptoms: Changes in appetite, sleep disturbances, and fatigue.
3. Cognitive Symptoms: Difficulty concentrating, making decisions, and memory issues.
4. Behavioral Symptoms: Loss of interest in activities, social withdrawal, and changes in daily routines.

Impact of Depression on Physical Health:

1. Aggravation of Chronic Conditions: Depression can worsen the symptoms of existing health conditions such as arthritis, asthma, cardiovascular disease, cancer, diabetes, and obesity.
2. Interconnected Health: Mental and physical health are interconnected, and depression can negatively influence the course and management of various medical conditions.

Holistic Approach to Depression Management:

1. Medical Treatment: Antidepressant medications prescribed by a healthcare professional.
2. Therapeutic Interventions: Psychotherapy, counseling, or cognitive-behavioral therapy.
3. Lifestyle Changes: Regular exercise, a healthy diet, and sufficient sleep can positively impact mood.
4. Social Support: Building and maintaining strong social connections.
5. Mind-Body Practices: Meditation, mindfulness, and relaxation techniques.

Individuals experiencing symptoms of depression should seek professional help. A healthcare provider can assess the severity of depression and recommend an appropriate treatment plan.

✔️ Pharmacology

Weak inhibitor of neuronal uptake of norepinephrine, serotonin, and dopamine.

✔️ Dosage & Administration of Zybex SR 150

Smoking Cessation:

• Adult: Modified-release preparation: Start with 150 mg once daily for 6 days, then increase to 150 mg twice daily. Treatment duration: 7-12 weeks. Discontinue if abstinence is not achieved by the 7th week. Maximum: 300 mg/day.
• Elderly: 150 mg/day.
• Hepatic Impairment:
  • Mild to moderate: 150 mg once daily.
  • Severe hepatic cirrhosis: Contraindicated.

Depression:

• Adult: Initially, 100 mg twice daily, increased to 100 mg three times daily after 3 days if necessary. Further increased to 150 mg three times daily if no improvement is observed after several weeks of therapy. Maximum: 150 mg three times daily.
• Modified-release preparation: 150 mg once daily in the morning, increased to 150 mg twice daily after 3 days if necessary. Further, increase to 200 mg twice daily after several weeks if needed. Maximum: 450 mg as a single dose.
• Elderly:
  • Immediate-release tab: Initially, 37.5 mg twice daily.
  • Sustained-release tab: Initially, 100 mg daily. The dose may be increased by 37.5-100 mg every 3-4 days as tolerated. Maximum: 300 mg daily in divided doses.
• Hepatic Impairment:
  • Mild to moderate: Reduce dose or dosing frequency.
  • Severe hepatic cirrhosis (immediate-release): Maximum 75 mg once daily.
  • Severe hepatic cirrhosis (modified-release): Maximum 100 mg once daily or 150 mg every other day.

Renal Dose:

• Renal impairment: Use caution; consider dose reduction.

✔️ Interaction

Neuroleptics, lithium, TCAs, benzodiazepines, alcohol, levodopa, fluoxetine, ritonavir, and MAO inhibitors.

✔️ Contraindications

Seizure Disorder:

• Contraindicated in patients with a history of seizure disorder.
• Bupropion may induce seizures, making it unsuitable for individuals with epilepsy.

Medication Containing Bupropion:

• Contraindicated in patients using other medications containing Bupropion.
• Increased risk of seizures, and incidence is dose-dependent.

Bulimia or Anorexia Nervosa:

• Contraindicated in patients with current or prior diagnosis of bulimia or anorexia nervosa.
• Higher incidence of seizures noted in such patients treated with Bupropion Hydrochloride.

Monoamine Oxidase (MAO) Inhibitor:

• Contraindicated in concurrent use with MAO inhibitors.
• At least 14 days should elapse between discontinuation of MAO inhibitor and initiation of Bupropion Hydrochloride treatment.

Allergic Response:

• Contraindicated in patients who have shown an allergic response to Bupropion or its components.

✔️ Pregnancy & Lactation

Limited human data; consider risks to the mother and fetus. Consult your doctor.

✔️ Precautions & Warnings

• Use with caution in seizure disorders, hepatic cirrhosis, CNS tumors, and alcohol or Benzodiazepine withdrawal.
• Caution in bipolar depression, psychoses, recent heart events, and hepatic or renal impairment.
• Enters breast milk; use caution during lactation.

✔️ Storage Conditions

Store at 15-30° C. Protect from light and moisture.