Frusiton 20 Tablet

✔️ Uses of Frusiton 20 Tablet

Treats-

• Edema (Fluid Retention)
• Hypertension (High Blood Pressure)

✔️ How does Frusiton 20 Tablet work?

E acts by removing the excess water and certain electrolytes (sodium and chloride) from the body in the form of urine while simultaneously maintaining the levels of potassium in the body.

✔️ Side Effects of Frusiton 20 Tablet

• Electrolyte disturbances
• Dehydration
• Hyponatremia (low sodium concentration in the blood)
• Hypochloraemia (low blood levels of chloride)
• Hypokalaemia (low potassium levels)
• Increased blood cholesterol
• Increased uric acid
• Low blood pressure (hypotension)
• Orthostatic hypotension
• Increased urine volume
• Headache
• Drowsiness/somnolence

✔️ Quick Suggestions:

• Furosemide + Spironolactone helps removes excess water from your body.
• Take it in the morning with breakfast to avoid getting up at night to urinate.
• It may cause dizziness or sleepiness. Don't drive or do anything requiring concentration until you know how it affects you.
• To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
• It may cause excessive urine production, dehydration, and low electrolyte levels. Notify your doctor if you experience dizziness, tiredness, or muscle weakness that doesn't go away.
• Your doctor may regularly monitor your blood pressure, kidney function, and the level of salts such as potassium and sodium

✔️ Indication

Frusemide 20mg + Spironolactone 50mg combination is indicated in-

• Essential hypertension
• Chronic congestive heart failure
• Hepatic cirrhosis, with collection of fluid in the abdominal cavity (ascites)
• Swelling due to excess fluid retention (edema)
• Hyperaldosteronism
• Resistant edema associated with secondary hyperaldosteronism

✔️ Pharmacology

Furosemide inhibits the reabsorption of Na+, Cl-, and K+. Continuous use may also lead to secondary hyperaldosteronism. Spironolactone is a specific antagonist of aldosterone. It increases Na and water excretion but retains K+. Thus it acts both as diuretic and an antihypertensive. It reduces edema and counteracts secondary aldosteronism caused by vol depletion Na loss. K loss is reduced.

✔️ Dosage & Administration of Frusiton 20 Tablet

The recommended adult dose of Frusiton 20 Tablet is 1 to 4 tablets per day, each containing furosemide 20 mg and spironolactone 50 mg. Take Frusiton 20 Tablets as prescribed by your physician. Swallow the tablets with a glass of water and do not crush or chew them. It is preferable to take the medication with meals.

Your doctor will determine the appropriate dose and duration of therapy based on factors such as your age, body weight, and the condition being treated. Avoid taking Frusiton 20 Tablet at night, as it may affect your sleep. Do not stop taking Frusiton 20 Tablets unless instructed to do so by your doctor.

✔️ Interaction

• Drug-Drug Interactions: Frusiton 20 Tablet may interact with other medications used to treat high blood pressure (metoprolol, ramipril, hydrochlorothiazide, atorvastatin), potentially leading to severe low blood pressure. It can also interact with drugs used to treat erectile dysfunction (sildenafil), anti-epilepsy medicines (carbamazepine, phenobarbital), immune-suppressing drugs (cyclosporine), and painkillers (ibuprofen, aspirin), among others.
• Drug-Food Interactions: It is advisable to avoid alcohol consumption while taking Frusiton 20 Tablets to prevent potential unpleasant side effects.
• Drug-Disease Interactions: Frusiton 20 Tablet should not be used in individuals with certain conditions, including cardiogenic shock, heart valve problems (stenosis), low blood pressure (hypotension), coronary heart disease, liver disease, heart failure, low serum potassium levels (hypokalemia), and patients with no urine output (anuria).

✔️ Contraindications

Frusiton 20 Tablet 10's is contraindicated in individuals with hypersensitivity to the medication, anuria or severe oliguria (significantly reduced urine output), hypovolemia (low blood volume), hyponatremia (low sodium levels in the blood), hypotension (low blood pressure), urinary retention due to prostatic hypertrophy (enlarged prostate), Addison's disease (adrenal insufficiency), renal impairment (kidney dysfunction), hyperkalemia (high potassium levels), acute or severe liver failure. It should not be used during pregnancy and lactation.

✔️ Pregnancy & Lactation

• Pregnancy: The use of Frusiton 20 tablets in pregnant women should be carefully considered, weighing the potential benefits against the possible risks to both the mother and the fetus. Spironolactone and its metabolites can cross the placental barrier. Animal studies with Furosemide indicate the possibility of fetal abnormalities, so it should only be used in women of childbearing age when appropriate contraceptive measures are taken or if the potential benefits outweigh the potential risks to the fetus.
• Lactation: Metabolites of Spironolactone have been found in breast milk. If the use of Frusiton 20 Tablet 10's is deemed essential, an alternative method of infant feeding should be considered. Furosemide is also excreted in breast milk, and breastfeeding should be discontinued if treatment with Frusiton 20 Tablet is necessary.

✔️ Precaution & Warnings:

Frusiton 20 Tablet is contraindicated in individuals with allergies to the medication, low blood pressure (less than 90 mm Hg), recent heart attack, severe kidney disease (creatinine clearance less than 30 mL/min), liver disease, pregnant women, those planning to become pregnant, and breastfeeding women. It should not be used in conditions like hypotension, cardiogenic shock, or aortic stenosis. If you are breastfeeding while taking Frusiton 20 Tablet, inform your doctor as its effects on the baby are not known. Special attention is needed for patients with significant voice usage (e.g., actors, singers, or teachers) as Frusiton 20 Tablet may cause vocal changes. Prior to using Frusiton 20 Tablet, correct any hypovolemia or dehydration with electrolyte and acid-base disturbances.

✔️ Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.