Alivio 1% Cream

Alivio Cream is used to treat a wide range of fungal infections of the skin and nails, including ringworm. It works by killing the fungus that causes the infection. Alivio Cream is for external use only. It should be used in the dose and duration suggested by the doctor. Applying it at the same time every day will help you remember to use it. The affected area should be clean and dry before application of the ointment. You must wash your hands thoroughly before and after applying this medicine. Do not stop using it until you have finished the complete course, even when you feel better. If you stop using this medicine too early, the fungus may continue to grow and the infection may return or worsen. The most common side effects of this medicine include application site reactions like burning, irritation, itching, and redness. These are usually mild but let your doctor know if they bother you or last more than a few days. Avoid direct contact with eyes, nose, or mouth. If accidental exposure occurs, rinse immediately with plenty of water. You must inform your doctor if there's no improvement even after four weeks of treatment. It is not likely that other medicines you take by mouth or injection will affect the way it works but talk to your doctor before using it if you have used a similar medicine before and had an allergic reaction. Pregnant and breastfeeding mothers should consult their doctor before using it.

Uses of Alivio Cream

• Fungal skin infections

Side effects of Alivio Cream

Common

• Skin peeling

How to use Alivio Cream

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.

How Alivio Cream works

Alivio Cream is an antifungal medication which treats skin infections. It works by killing the fungi on the skin by destroying their cell membrane.

What if you forget to take Alivio Cream?

If you miss a dose of Alivio Cream, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Quick Tips

• Alivio Cream helps treat skin infections caused by many different types of fungi.
• Finish the full course of treatment even if you feel better.
• It can take a few weeks for the infection to clear and a few months before the skin returns to its normal color.
• Apply an amount sufficient to cover the affected area and 1 inch of the immediate surrounding skin.
• It can make your skin more sensitive to sun. Use broad-spectrum sunscreen and protective clothing when outdoors.
• Avoid getting in the eyes, nose, or mouth. If accidental exposure occurs, rinse immediately with plenty of water.
• Inform your doctor if the infection has not cleared up after four weeks of treatment.

Brief Description

Indication

Tinea pedis, Tinea cruris, Tinea corporis, Dermatophytosis, Nail infections, Cutaneous candidiasis, Pityriasis versicolor

Adult Dose

Topical/Cutaneous As cream or spray Dermatophytosis Adult: Tinea Pedis: Apply to affected area BID until significant clinical improvement (no more than 4 weeks) Tinea Corporis & Cruris: Apply once daily, for 1 week, (no more than 4 weeks) Cutaneous candidiasis and pityriasis versicolor: Apply once or bid for 2 wk

Child Dose

Not FDA approved for peds

Contraindication

Hypersensitivity, active or chronic liver disease, lactation.

Mode of Action

Terbinafine causes fungal cell death by inhibiting squalene epoxidase, the main enzyme in sterol biosynthesis, resulting in ergosterol deficiency within fungal cell walls. It has fungicidal activity against dermatophytes and some yeast.

Precaution

Preexisting liver or renal impairment, pregnancy. Perform liver function tests prior to oral therapy. Lactation: not safe for nursing infants

Side Effect

1-10% Burning,Contact dermatitis,Dryness,Exfoliation,Irritation,Pruritus,Rash,Irritation,Stinging Potentially Fatal: Liver failure, Stevens-Johnson syndrome, neutropaenia.

Interaction

Possible increase in levels in drugs metabolised by CYP450 2D6. Decreased terbinafine concentration with rifampicin; increased terbinafine concentration with cimetidine.