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Giran-H Tablet 10pcs
This is indicated for the treatment of hypertension, congestive heart failure.
Tablet Manufacturer/Distributor: Aristopharma Limited Generic Name: Candesartan Cilexetil 8 mg + Hydrochlorothiazide 12.5 mg Tablet
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✅ Description:
Indications of Giran-H Tablet
Giran-H Tablet is used to treat hypertension, heart failure, and left ventricular systolic dysfunction.
Pharmacology of Giran-H Tablet
Candesartan Cilexetil is an ester prodrug that's hydrolyzed within the body to the dynamic shape Candesartan amid assimilation from the gastrointestinal tract. Candesartan is angiotensin II receptor (sort AT1) adversary. Candesartan pieces the vasoconstrictor and aldosterone-secreting impacts of angiotensin II by specifically blocking the official of angiotensin II to the AT1 receptor in numerous tissues (eg, vascular smooth muscle, adrenal organ).
Giran-H Tablet Administration & Dosage
Hypertension: initially 8 mg (hepatic impairment 2 mg, renal impairment or intravascular volume depletion 4 mg) once daily, increased if necessary at intervals of 4 weeks to max 32 mg once daily; usual maintenance dose 8 mg once daily.
Heart failure: initially 4 mg once daily, increased at intervals of at least 2 weeks to target dose of 32 mg once daily or to max tolerated dose.
Interaction
No noteworthy sedate intelligence has been detailed in considering Candesartan Cilexetil given with other drugs such as glyburide, nifedipine, digoxin, warfarin, hydrochlorothiazide, and verbal contraceptives in solid volunteers. Since candesartan isn't metabolized by the cytochrome P-450 framework and has no impact on P-450 proteins, intelligence with drugs that restrain, or are metabolized by, those proteins seem not to be expected.
Contraindications
Hypersensitivity to any of the product's ingredients. Cholestasis, pregnancy, and breast-feeding
Giran-H Tablet Side Effect
Side effects are ordinarily mellow. Symptomatic hypotension counting tipsiness may happen, especially in patients with intravascular volume consumption (e.g. those taking tall measurements diuretics). Hyperkalemia happens occasionally; angioedema has moreover been detailed with a few angiotensin II receptor enemies. Moreover vertigo, cerebral pain; once in a while hepatitis, blood clutters, hyponatremia, back torment, arthralgia, myalgia, hasty, urticaria, and pruritus.
Pregnancy & Lactation
Giran-H Tablet should be stopped as soon as possible if pregnancy is discovered. It's a good idea to use it during lactation.
Precautions & Warnings
In renal artery stenosis, aortic or mitral valve stenosis, and obstructive hypertrophic cardiomyopathy, candesartan should be used with caution. The elderly and patients with renal impairment should have their plasma potassium concentrations monitored; lower initial doses may be appropriate for these patients.
Storage Conditions
Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.
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