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Vasopril 5mg 10pcs
Tablet Manufacturer/Distributor: Square Pharmaceuticals Ltd. Generic Name: Enalapril Maleate 5 mg Tablet
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✅ Description:
Indications of Vasopril 5 Tablet
- Enalapril is used to treat a variety of conditions.
- Essential hypertension and renovascular hypertension of all grades, either alone or in conjunction with other antihypertensive drugs, particularly thiazide diuretics.
- Symptomatic heart failure prevention.
- Congestive heart failure (adjunct) treatment, generally in conjunction with diuretics and digitalis.
- In individuals with left ventricular dysfunction, preventing coronary ischemic episodes is a priority.
- Enalapril is also used to treat angina, diabetic nephropathy, and Raynaud's disease, either alone or in combination with other medications.
Pharmacology of Vasopril 5 Tablet
Enalapril inhibits Angiotensin Converting Enzyme following hydrolysis to enalaprilat (ACE). The conversion of angiotensin I to the vasoconstrictor chemical angiotensin II is catalyzed by ACE, a peptidyl dipeptidase. Angiotensin II also increases adrenal cortex aldosterone secretion. Enalapril's favorable benefits in hypertension and heart failure appear to be largely due to its inhibition of the renin-angiotensin-aldosterone pathway.
Dosage & Administration of Vasopril 5 Tablet
Hypertension: Initially 5 mg once daily if used alone or 2.5 mg daily if used in addition to a diuretic, in elderly patients or in patients with renal impairment. The usual maintenance dose is 10-20 mg once daily. However, in severe hypertension, it may be increased to a maximum of 40 mg once daily.
Heart failure (adjunct) and asymptomatic left ventricular dysfunction: Initially 2.5 mg under close medical supervision. The usual maintenance dose is 20 mg daily in 1-2 divided doses
Interaction of Vasopril 5 Tablet
Combining b blockers, Methyldopa, calcium antagonists, and diuretics with other antihypertensive drugs may improve hypertension effectiveness. Adrenergic blockers should only be used in conjunction with Enalapril under strict supervision. Concomitant Propranolol may decrease Enalapril bioavailability, however, this does not appear to be clinically significant. Concurrent Lithium treatment may result in a rise in serum Lithium concentration.
Contraindications
Aortic stenosis or blockage of the outflow tract. Renovascular disease is a condition that affects the kidneys. HTN with a high level of resistance. Generalized atherosclerosis or peripheral vascular disease.
Side Effects of Vasopril 5 Tablet
The most frequent adverse effects are dizziness and headache. In 2-3 percent of individuals, fatigue and asthenia were noted. Hypotension, orthostatic hypotension, syncope, nausea, diarrhea, muscular cramps, rash, and cough were among the fewer than 2% of individuals who experienced other adverse events.
Renal impairment, renal failure, and oliguria have been described less often. Rarely, angioedema, hyperkalemia, and hyponatremia have been observed.
Pregnancy & Lactation
Category D: Pregnancy is contraindicated. Because the medication is excreted in tiny amounts in human milk, it should be given with caution to nursing mothers.
Precautions & Warnings
In patients with collagen vascular disease, such as SLE and scleroderma, assess renal function and do frequent WBC counts. Patients on immunosuppressive treatment; individuals who are prone to dehydration or salt deficiency. Pregnancy.
Storage Conditions
Keep away from light and heat in a dry area. Keep out of children's reach.
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