Cotrim 400mg 10pcs

Indications

Cotrimoxazole is bactericidal in vitro to a wide run of Gram-positive and Gram-negative living beings, counting Streptococcus, Staphylococcus, Pneumococcus, Neisseria, B. catarrhalis, Escherichia coli, Klebsiella, Proteus spp., Haemophilus, Salmonella, Shigella, Vibrio cholerae, Brucella, Pneumocystis carinii, Nocardia and Bordetella. A especially tall degree of action is shown against Haemophilus influenzae, E. coli and Proteus spp., making Cotrimoxazole especially appropriate for the treatment of constant bronchitis and urinary tract contaminations. Cotrimoxazole applies its bactericidal activity by the consecutive bar of two bacterial chemical frameworks within the biosynthesis of Folinic corrosive within the micro-organisms. The collaboration hence created accounts for the tall degree of bactericidal activity.

Signs are : Respiratory tract diseases, counting intense and incessant bronchitis (treatment and prophylaxis), bronchiectasis, lung boil, lobar and broncho-pneumonia, Pneumocystis carinii pneumonitis, sinusitis and otitis media. Genito-urinary tract diseases, counting urethritis, intense and incessant cystitis, pyelonephritis, prostatitis and gonorrhoea. Gastro-intestinal tract diseases, caused by Salmonella typhi and Salmonella paratyphi, counting the incessant carrier state. Other diseases, caused by a wide run of life forms affirmed to be vulnerable to Cotrimoxazole and where the restorative benefits are considered to exceed the conceivable event of unfavorable events. Such contaminations incorporate intense and persistent osteomyelitis, intense brucellosis, skin diseases counting pyoderma, abscesses and wound diseases, septicaemia, bacillary loose bowels and cholera (as an adjuvant to liquid and electrolyte substitution), nocardiosis and mycetoma.

Pharmacology

Cotrimoxazole having wide range bactericidal movement against a wide run of gram-positive & gram-negative microscopic organisms and a few protozoa. Co-trimoxazole containing Trimethoprim and Sulphamethoxazole in a 1:5 combination applies its bactericidal activity by the successive barricade of two bacterial chemical frameworks within the biosynthesis of folinic corrosive within the microorganism.

Administration & Dosage

Cotrimoxazole double strength tablet: Over 12 years

For mild to moderate infections: 1 tablet twice daily.

For severe infections: 1.5 tablets twice daily.

Long term therapy (>14 days): 0.5 tablet twice daily.

Gonorrhoea: 2 tablets every 12 hours for two days or 2.5 tablets followed by a further dose of 2.5 tablets after 8 hours.

Cotrimoxazole tablet: over 12 years

For mild to moderate infections: 2 tablets twice daily.

For severe infections: 2 tablets thrice daily.

Long term therapy: (>14 days): 1 tablet twice daily.

Cotrimoxazole suspension: Under 12 years

6-12 years: 2 teaspoonful twice daily.

6 month-5 years: 1 teaspoonful twice daily.

6 weeks-6 months: 0.5 teaspoonful twice daily.

Interaction

Antidepressants such as SSRIs and related antidepressants should not be started for at least two weeks after stopping an MAOI. An MAOI, on the other hand, should not be started until at least one week after an SSRI or similar antidepressant has been discontinued (2 weeks in the case of paroxetine and sertraline, at least 5 weeks in the case of fluoxetine).

Contraindications

Touchiness to trimethoprim or sulphonamides. Patients with reported megaloblastic weakness due to folate deficiency. Patients appearing stamped liver parenchymal harm, blood dyscrasia, serious renal inadequate, glucose 6-phosphate dehydrogenase lack.

Side Effect

The side impacts like crystalluria, unfavorably susceptible responses, haemolysis, thrombocytopenia, neutropenia, agranulocytosis etc. have been detailed seldom with Sulphamethoxazole-Trimethoprim combination. Other side impacts are less genuine in nature such as discomfort, migraine, sickness and spewing. These are ordinarily temporal and don't require withdrawal of treatment.

Pregnancy & Lactation

Pregnancy and amid the nursing period, since sulphonamides pass the placenta and are excreted within the breast drain and may cause kernicterus.

Precautions & Warnings

Drawn out full measurements treatment with sulfamethoxazole-trimethoprim combination is related with the chance of macrocytic frailty due to the drug’s obstructions within the transformation of Folic corrosive into Folinic corrosive. In case this happens, it can be turned around by giving Folinic corrosive. Care ought to be taken when giving this combination to diabetic patients accepting sulphonylurea medicate for conceivable potentiation of activity of sulphonylurea.

Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.