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Somarant 10mg 10Pcs
Suvorexant is a medication used to treat insomnia. (difficulty falling asleep or staying asleep). Suvorexant belongs to a family of drugs known as orexin receptor antagonists. It works by inhibiting the effect of a naturally occurring chemical in the brain that induces wakefulness.
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✅ Description:
Indications
Suvorexant is used to treat insomnia, which is characterized by problems falling asleep and staying asleep.
✔️ Uses of Somarant
- Insomnia
✔️ Pharmacology
Suvorexant is a highly selective orexin receptor OX1R and OX2R antagonist. Suvorexant's therapeutic effect on insomnia is thought to be due to orexin receptor antagonism. The orexin neuropeptide signaling pathway is a key factor in promoting alertness. Wake drive is considered to be suppressed by blocking the binding of the wake-promoting neuropeptides orexin A and orexin B to the receptors OX1R and OX2R.
✔️ Dosage & Administration
Adult Dose:
- The recommended dose is 10 mg, no more than once per night taken before 30 minutes of going to bed, with at least 7 hours remaining before the planned time of awakening.
- If the 10 mg dose is well-tolerated but not effective, the dose can be increased, not to exceed 20 mg once daily.
- The lowest dose effective should be used for the patient.
- Time to effect may be delayed if taken with or soon after a meal.
Child Dose:
- Safety and efficacy not established
Renal Dose:
- Renal impairment: No dosage adjustment is required
✔️ Interaction
CNS Active Drug: When a single 40 mg dose of Suvorexant was co-administered with a single 0.7 g / kg alcohol dose, an additive effect on psychomotor performance was observed. Suvorexant does not affect alcohol concentration and alcohol does not affect Suvorexant concentration.
Effects of other medications on Suvorexant: Strong (eg ketoconazole or itraconazole) and moderate CYP3A inhibitors (eg diltiazem) significantly increase exposure to Suvorexant. Strong CYP3A inducers (eg, rifampicin) significantly reduce exposure to Suvorexant.
Effect of Suvorexant on other drugs: Suvorexant is unlikely to have a clinically significant inhibitory effect on human CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19 or CYP2D6. Long-term administration of Suvorexant is unlikely to induce the metabolism of drugs metabolized by the major CYP isoforms.
✔️ Contraindications
In individuals with narcolepsy, do not use it.
✔️ Side Effects
- Sleepiness during the day
- Inability to think properly
- Acting oddly, puzzled
- Upset
- Sleep-walking
✔️ Pregnancy & Lactation
Pregnancy Classification C. In pregnant women, there are no appropriate and well-controlled trials. Suvorexant should only be used while pregnant if the possible benefit outweighs the danger to the fetus.
✔️ Precautions & Warnings
Daytime somnolence: Risk of poor alertness and motor coordination, including impaired driving; risk rises with dose; warn patients taking 20 mg not to drive or do anything else that requires complete mental alertness the next day.
Evaluation for co-morbid disorders is required: If sleeplessness continues after 7 to 10 days of therapy, reevaluate.
✔️ Storage Conditions
Store in a dry and cool place, protect from light & keep away from children.
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