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Arinet is an antiparasitic medication primarily used for the treatment of malaria.
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✅ Description:
Arinet, an artemisinin derivative, is a potent antimalarial drug indicated for the following conditions:
- Treatment of severe and complicated malaria caused by Plasmodium falciparum in both adults and children.
- Treatment of uncomplicated malaria in areas with multidrug-resistant Plasmodium falciparum.
- Suitable for salvaging patients with pernicious malaria and treating malaria caused by Plasmodium falciparum and Plasmodium vivax.
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✔️ Uses of Arinet 50mg Tablet
Malaria, Schistosomiasis
✔️ How does Arinet 50mg Tablet work?
Arinet acts as an antiparasitic by generating harmful chemicals (free radicals) within the malarial parasite, leading to its destruction.
✔️ Side Effects of Arinet 50mg Tablet
Common side effects may include:
- Headache
- Dizziness
- Weakness
- Loss of appetite
✔️ Quick Suggestions:
- Arinet is specifically used for treating malaria.
- Inform your doctor about any allergies to Arinet.
- Avoid using Arinet in the first 3 months of pregnancy; consult your doctor if you are breastfeeding.
- Driving or operating machinery should be avoided after taking Arinet due to potential dizziness or sleepiness.
- Take Arinet with food or drinks enriched with fat.
- Complete the full course of treatment, even if symptoms improve.
- Be cautious as it may cause dizziness and sleepiness.
- Avoid during the first 3 months of pregnancy and inform your doctor if breastfeeding.
- Report flu-like symptoms or any changes in heartbeat.
- Regular blood tests may be required during treatment.
✔️ Indications of Arinet 50mg Tablet
- Treatment of Malaria
✔️ Pharmacology:
Artesunate, the active component, is metabolized to the active DHA. It generates free radicals inhibiting protein and nucleic acid synthesis in Plasmodium parasites during all erythrocytic stages. It may also lead to alkylation of parasitic proteins.
✔️ Dosage & Administration of Arinet 50mg Tablet
Artesunate 50 mg tablet:
- Adults: Two tablets twice on the first day, followed by one tablet twice daily for the next four days (4, 2, 2, 2, 2).
- Children:
- 1-3 years: 3 tablets for 5 days (1, 1⁄2, 1⁄2, 1⁄2, 1⁄2)
- 4-5 years: 6 tablets for 5 days (2, 1, 1, 1, 1)
- 6-12 years: 8 tablets for 5 days (3, 2, 1, 1, 1)
Artesunate 100 mg tablet:
- Adults: One tablet twice on the first day, followed by half a tablet twice daily for the next four days (2, 1, 1, 1, 1).
- Children:
- 4-5 years: 3 tablets for 5 days (1, 1⁄2, 1⁄2, 1⁄2, 1⁄2)
- 6-12 years: 4 tablets for 5 days (1 1⁄2, 1, 1⁄2, 1⁄2, 1⁄2)
- Patients aged over 12 years: Same as adult dose.
Dosage for Malaria Prevention: Two Artesunate 50 tablets (or one Artesunate 100 tablet) as a single dose once a week, from one week before entering a malaria-affected area to four weeks after leaving.
Renal Dose: Artesunate, the active ingredient, is derived from the Chinese herb Artemisia annua and is a potent blood schizontocide.
✔️ Interaction
- Interaction with other artemisinin drugs (e.g., artemether, arteether) prolongs PQ and QT interval.
- Interaction with antimalarial drugs (e.g., quinine, quinidine, mefloquine, halofantrine) with cardiac action.
- Interaction with drugs prolonging QT interval (e.g., erythromycin, terfenadine, astemizole, probucol, procainamide, disopyramide, amiodarone, bretylium, bepridil, sotalol, tricyclic antidepressants, and neuroleptics).
✔️ Contraindications
Artesunate is contraindicated in patients with known hypersensitivity to Artemisinin and its derivatives or inactive ingredients.
✔️ Pregnancy & Lactation
Considered safe for treating malaria in pregnancy, but further study is needed. Use with caution during breastfeeding, and it's recommended to stop breastfeeding during treatment.
✔️ Precautions & Warnings
- Caution in severe vomiting patients.
- Intravenous or intramuscular injection is preferred for emergency severe malaria treatment.
- Use under the advice of a Registered Physician.
- Do not exceed the recommended dose.
✔️ Storage Conditions
Keep below 30°C, away from light and moisture. Keep out of reach of children.
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