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- Quinine sulfate capsule is a cinchona alkaloid indicated for treatment of uncomplicated Plasmodium falciparum malaria
- Quinine sulfate is not recommended for use in children (under 10 years).
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✅ Description:
The use of quinine sulfate capsules for the treatment or prevention of nocturnal leg cramps carries significant risks, including serious and potentially life-threatening hematologic reactions such as thrombocytopenia and hemolytic uremic syndrome/thrombotic thrombocytopenic purpura
- Nocturnal leg cramps: Quinine sulfate capsules are sometimes used off-label for this condition.
Before taking Quinine sulfate inform your doctor if you have had malaria for a long time, suffer from severe glucose-6-phosphate dehydrogenase deficiency (G6PD).
Quinine sulfate is not recommended for use in children (under 10 years). Consult your doctor before taking it.
Quinine sulfate should be used with caution in elderly patients (aged 65 years and above). Proper dose adjustment and careful monitoring are required in such patients. Consult your doctor before taking it.
Quinine sulfate Should be taken with caution in patients with irregular heartbeat or any other heart disease, or those who have or were born with any condition that causes an abnormal heart rhythm. Consult your doctor before taking it.
Safety Advices
Alcohol
No interaction found/established
Pregnancy
UNSAFE
Quinine sulfate is not recommended for use in pregnant women unless considered clearly necessary. Quinine sulfate should not be taken for cramps during pregnancy. Consult your doctor before taking it.
Breastfeeding
UNSAFE
Quinine sulfate is not recommended for use in breastfeeding women unless considered clearly necessary. Consult your doctor before taking it.
Driving
CAUTION
Do not drive or operate any machines if you feel that your vision is affected or causes vertigo (dizziness or spinning sensation) after taking Quinine sulfate.
Kidney
CONSULT YOUR DOCTOR
Tell your doctor if you have any kidney disease, before taking Quinine sulfate.
Liver
CONSULT YOUR DOCTOR
Tell your doctor if you have any liver disease, before taking Quinine sulfate
✔️ Uses of Quinine sulfate
- Used to manage malaria
✔️ Dosage of Quinine sulfate
- Adults (≥ 16 years of age): 648 mg (two capsules) every 8 hours for 7 days.
- Patients with severe chronic renal impairment: One loading dose of 648 mg (two capsules) followed by 324 mg (one capsule) every 12 hours for 7 days.
✔️ Use in Specific Populations
- Renal impairment: Adjust dose and dosing frequency for patients with severe chronic renal impairment.
- Hepatic impairment: Avoid use in patients with severe hepatic impairment (Child-Pugh C).
- Pregnancy: Use only if potential benefit justifies the risk to the fetus.
- Nursing mothers: Use with caution; potential risk to the nursing infant.
✔️ Administration:
Take Quinine sulfate as advised by your physician. Swallow it with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you based upon your age, body weight and disease condition.
✔️ Adverse Reactions/Side Effects
- Cinchonism: Cluster of symptoms including headache, nausea, tinnitus, vertigo, blurred vision, and disturbances in cardiac rhythm or conduction.
- Serious adverse reactions such as thrombocytopenia and QT prolongation have also been reported.
✔️ Drug Interactions
- QT prolonging agents (e.g., Class IA and III antiarrhythmics): Avoid concomitant use due to increased risk of QT prolongation and Torsades de Pointes.
- Other antimalarials (e.g., halofantrine, mefloquine): Avoid concomitant use due to potential ECG abnormalities.
- CYP3A4 inducers or inhibitors: Monitor for altered plasma quinine concentrations.
- Digoxin: Monitor digoxin levels closely when used concomitantly.
✔️ Contraindication
- Prolongation of QT interval
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency
- Myasthenia gravis
- Known hypersensitivity to quinine, mefloquine, or quinidine
- Optic neuritis
✔️ Warnings and Precautions
- Not indicated for the prevention or treatment of nocturnal leg cramps due to serious and life-threatening adverse reactions.
- Thrombocytopenia: Discontinue if thrombocytopenia occurs.
- QT prolongation and ventricular arrhythmias: Avoid concomitant use with drugs known to prolong QT interval.
- Hypersensitivity reactions: Discontinue drug if hypersensitivity reactions occur.
- Hypoglycemia: Monitor for signs and symptoms.
✔️ Storage
Keep in a dry place, away from light and heat. Keep out of the reach of children.
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