Malex 500mg 10pcs - ePharma
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Malex 500mg 10pcs

Generic: Sulfadoxine 500mg + pyrimethamine 25mg

Type: Tablet

Pack Size: 10 Pcs

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Tablet. Generic Name: Sulfadoxine 500mg + pyrimethamine 25mg/tablet. Manufacturer/Distributor: Ibn Sina


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Discount Price: ৳ 38.54
MRP: ৳ 41 6% Off

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✅ Description:

Indications

Treatment of all forms of malaria due to Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae. The drug is also indicated for suppressive or prophylactic management, particularly in areas where resistance to chloroquine is known to exist.

Pharmacology

Sulphadoxine & Pyrimethamine is an antimalarial agent embodying the concept of synergism. Individually the components of this preparation exert inferior result with higher doses in comparison with that obtained with the combination. Moreover, this preparation is effective against strains that are resistant to other antimalarial agents and the risk of resistance development is minimum with this preparation. It is extremely long acting drug, attacks the different development stages of the parasite and attains effective concentration with a single dose. The protective effect of a single dose lasts for approximately four weeks and this preparation is compatible with other antimalarial drugs and with antibiotics. It does not influence the action of antidiabetic agents.

Dosage & Administration

Curative treatment of malaria with a single dose-

  • Adults: 2-3 tablets
  • Children under 4 years: ½ tablets
  • 4-8 years: 1 tablet
  • 9-14 years: 2 tablets

In severe cases, Sulphadoxine & Pyrimethamine can be beneficially combined with quinine.

Suppressive or prophylactic management-

The dose given below should be taken at one time:

For semi-immune subjects (Dose: once every four weeks)-

  • Adults: 2-3 tablets
  • Children under 4 years: ½ tablets
  • 4-8 years: 1 tablet
  • 9-14 years: 2 tablets

For non-immune subjects (Dose: Once every two weeks)-

  • Adults: 2 tablets
  • Children under 4 years: 1½ tablets
  • 4-8 years: 1 tablet
  • 9-14 years: 1½ tablets

For malaria prophylaxis: The first dose of Sulphadoxine & Pyrimethamine should be taken one or two days before departure for an endemic area in order to protect tolerance, administration should be continued in the above dosage during the stay and also for four weeks after return or as prescribed by the physician.

Interaction

Concurrent administration of other preparations containing folate antagonists (e.g. cotrimoxazole, methotrexate, anticonvulsants) can result in increased impairment of folic acid metabolism, which leads to haematological side effects.

Contraindications

Prophylactic (repeated) use of Pyrimethamine + Sulphadoxine is contraindicated in patients with severe renal insufficiency, marked liver parenchymal damage or blood dyscrasias. Treatment must be immediately discontinued upon the appearance of any mucocutaneous signs or symptoms such as pruritus, erythema, rash, orogenital lesions or pharyngitis.

Side Effects

Sulphadoxine & Pyrimethamine at the recommended dose is well tolerated. Main side effects are given below

  • Skin reactions: Drug rash, pruritus and slight hair loss have been observed.
  • Gastro-intestinal reactions: Feeling of fullness, nausea, rarely vomiting, stomatitis.
  • Haematological reactions: In rare cases, leukopenia, thrombocytopenia, and megaloblastic anemia have been observed.
  • Other reactions: Fatigue, headache, fever, polyneuritis may occasionally occur.

Pregnancy & Lactation

Sulphadoxine & Pyrimethamine is contraindicated during pregnancy, premature and newborn infants during the first weeks of life and intolerance to sulfonamide. If pregnancy can not be excluded, possible risks should be balanced against therapeutic effect. Both Pyrimethamine and Sulphadoxine are excreted in maternal breast milk. Nursing mother should not take this preparation.

Precautions & Warnings

Impaired renal or hepatic function, folate deficiency, severe allergy or bronchial asthma, G6PD deficiency, pregnancy. Take with plenty of water to prevent crystalluria. Avoid excessive exposure to sun. Discontinue at the first sign of rash. Discontinue if signs of folic acid deficiency develops. Regular CBC monitoring, LFT, analysis of urine for crystalluria when admin for > 3 mth. Take with food to minimise Gi effects (e.g. anorexia and vomiting).

Therapeutic Class

Anti-malarial drugs

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

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Check our pricing section for Malex 500mg 10pcs price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

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ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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