Biocal Kit | 150mg+600mg+400IU

✔️ Biocal Kit Tablet Composition:

 Ibandronic Acid 150 mg + Algae Calcium 600 mg + Vitamin D3 400 IU

✔️ Side Effects

Common: Back pain, headache, GI disturbances (dyspepsia, constipation, diarrhea, flatulence, abdominal discomfort), myalgia, and limb pain.

✔️ Dosage & Administration

Day 1–10: Take one Calcium + Vitamin D3 tablet daily after meals.

Day 11: Take one Ibandronic Acid tablet with a full glass of plain water on an empty stomach, at least 1 hour before breakfast. The patient must remain upright (sitting or standing) and avoid food or drinks (except water) for 1 hour.

Day 12–30: Continue with one Calcium + Vitamin D3 tablet daily after meals.

⚠️ Safety and effectiveness in children and adolescents have not been established.

✔️ Overdose Management

Ibandronic Acid: May cause hypocalcemia, hypophosphatemia, and GI symptoms. Treat with milk or antacids to bind drug.

Calcium + Vitamin D3: Overdose may lead to nausea, vomiting, drowsiness, constipation, weakness, or kidney issues. Treatment includes discontinuation and rehydration.

✔️ Drug Interactions

Ibandronic Acid: Absorption may be reduced by calcium, iron, magnesium, or aluminium. Caution with aspirin and NSAIDs due to GI irritation risk.

Calcium + Vitamin D3: May interact with digoxin, antacids, other calcium supplements, calcitriol, tetracyclines, thiazide diuretics, phenytoin, barbiturates, and corticosteroids. Certain foods (milk, cereals, spinach) may also reduce calcium absorption.

✔️ Contraindications

Ibandronic Acid: Esophageal abnormalities (e.g., stricture, achalasia), inability to sit/stand upright for 60 minutes, hypocalcemia.

Calcium + Vitamin D3: Hypercalcemia, hyperparathyroidism, hypercalciuria, nephrolithiasis, severe renal impairment, digoxin therapy, Zollinger–Ellison syndrome.

✔️ Pregnancy & Lactation

Not recommended during pregnancy or breastfeeding due to insufficient safety data.

The kit is not intended for use in women of reproductive age.

✔️ Precautions & Warnings

Ibandronic Acid: Use cautiously in patients with GI disorders (e.g., Barrett’s esophagus, ulcers). Treat hypocalcemia before initiation. Discontinue if severe musculoskeletal pain, osteonecrosis of the jaw, or atypical femoral fractures occur. Avoid use in severe renal impairment (CrCl <30 ml/min).

Calcium + Vitamin D3: Monitor plasma and urinary calcium in patients with renal impairment or hypercalciuria. Use cautiously in kidney stones, sarcoidosis, and heart disease. Ensure adequate hydration in patients with a history of renal calculi. Separate calcium and iron doses by several hours.

✔️ Storage:

Store below 30°C in a cool, dry place.

Protect from light and moisture.

Keep out of children’s reach.