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Home Medicines Cancer/oncology Bleocin Injection 15 unit

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Bleocin Injection 15 unit

Name: Bleocin Injection 15 unit
Brand: Nippon Kayaku/NTS
Price: 1058 BDT
Availability: InStock
Rating: 4.8 (85 reviews)

Nippon Kayaku/NTS

Generic: Bleomycin

Type: Injection

Pack Size: 1 Pc

Injection

৳ 1125 ৳ 1103

Bleomycin (as sulphate) 15mg/ampoule (powder for reconstitution): Injection.

Though the exact mechanism of action is not fully established, Bleomycin mainly inhibits DNA synthesis, with minor effects on RNA and protein synthesis. It induces single-strand and some double-strand DNA breaks and arrests the cell cycle at the G2 and mitosis phases. When administered intrapleurally, it acts as a sclerosing agent.

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✅ Description:

Bleocin is primarily used as a palliative treatment and has demonstrated efficacy either alone or in combination with other approved chemotherapeutic agents in the management of the following malignancies:

Squamous Cell Carcinomas: Including tumors of the head and neck (e.g., mouth, tongue, tonsils, nasopharynx, oropharynx, sinuses, palate, lips, buccal mucosa, gingivae, epiglottis, skin, and larynx), as well as cancers of the penis, cervix, and vulva. Patients previously treated with radiotherapy for head and neck cancers may show a reduced response.
Lymphomas: Both Hodgkin’s disease and non-Hodgkin lymphoma.
Testicular Cancers: Effective against embryonal carcinoma, choriocarcinoma, and teratocarcinoma.
Malignant Pleural Effusion: Administered as an intrapleural sclerosing agent.

Note: Use only as directed by a registered physician.

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✔️ Dosage & Administration

Initial Testing Dose (Lymphoma): ≤2 units for the first two doses to monitor for anaphylactoid reactions.
Standard Regimen (Squamous Cell Carcinoma, Testicular Cancer, Non-Hodgkin’s Lymphoma):
0.25–0.50 units/kg (10–20 units/m²) via IV, IM, or SC weekly or twice weekly.
Hodgkin’s Disease:
Same initial dosing; if 50% response is achieved, continue with 1 unit daily or 5 units weekly (IV or IM) as maintenance.

Malignant Pleural Effusion:
60 units via single-dose intrapleural bolus.

⚠️ Cumulative doses exceeding 400 units significantly increase the risk of pulmonary toxicity and must be administered with caution, especially in combination regimens.

Pediatrics: Safety and efficacy not established.

Geriatrics: Higher incidence of pulmonary toxicity in patients >70 yea

✔️ Overdose Management

Symptoms include hypotension, fever, tachycardia, and shock-like symptoms. Treatment is symptomatic; respiratory complications should be addressed with corticosteroids and broad-spectrum antibiotics.

✔️ Side Effects

Common: Injection site reactions, fever, chills, nausea, appetite and weight loss, skin discoloration, nail changes, and tumor-site pain.
Serious: Pulmonary fibrosis, particularly with high cumulative doses.

✔️ Reconstitution Guidelines

IM/SC: Add 1–5 mL (15 IU) or 2–10 mL (30 IU) of sterile water, NaCl 0.9%, or bacteriostatic water to achieve 3–15 IU/mL.
IV: Reconstitute with 5 mL (15 IU) or 10 mL (30 IU) of NaCl 0.9% for ≤3 IU/mL. Administer slowly over 10 minutes.
Intrapleural: Dissolve 60 IU in 50–100 mL of NaCl 0.9%.

✔️ Drug Interactions

Increased pulmonary toxicity when used before or after chest radiotherapy.
Vinca alkaloids may precipitate Raynaud 's-like ischemia, potentially leading to peripheral necrosis.
May impair phenytoin absorption.
Co-administration with clozapine increases the risk of agranulocytosis.

✔️ Contraindications

Acute pulmonary infections or severely impaired lung function.
Concomitant use with brentuximab, cisplatin, or high-concentration oxygen therapy.
Breastfeeding is contraindicated.

✔️ Use in Pregnancy & Lactation

Pregnancy Category D: Known risk to the fetus.

Unknown if excreted in breast milk. Due to potential risks, breastfeeding should be avoided during treatment.

✔️ Precautions & Warnings

Use with caution in patients with renal impairment, cardiovascular disease, the elderly, or those who are pregnant.

✔️ Storage

Store at 2–8°C.

Protect from light and do not use beyond the expiration date.

Frequently Asked Questions (FAQ)

+ Q. What is Bleocin used for?

Bleocin is primarily used in the treatment of various cancers including: Cervical cancer Squamous cell carcinoma of the mouth, larynx, nasopharynx, skin, and esophagus Lymphomas (Hodgkin's and non-Hodgkin's) Testicular cancer (e.g., embryonal cell, choriocarcinoma, teratocarcinoma) Malignant pleural effusion (as a sclerosing agent)

+ Q. What are the common side effects of Bleocin?

Fever, chills, rigors Nausea, vomiting, weight loss Loss of appetite, hair loss Skin pigmentation, scratch dermatitis Nail discoloration, stomatitis Pulmonary toxicity (interstitial pneumonia, fibrosis)

+ Q. How should Bleocin be stored?

Store at 2–8°C (refrigerated). Protect from light. Do not use past the expiration date.

+ Q. What happens in case of Bleocin overdose?

Symptoms: Hypotension, fever, fast heart rate, shock-like symptoms. Treatment: Symptomatic support; corticosteroids and antibiotics may be used for respiratory complications.

+ Q. What are the serious side effects of Bleocin?

Pulmonary fibrosis (can be fatal) Anaphylactoid reactions Confusion, hypotension Myocardial infarction, stroke Raynaud’s phenomenon (with vinca alkaloids) Agranulocytosis (with clozapine)

+ Q. Are there any drug interactions with Bleocin?

Yes. Bleocin may interact with: Vinca alkaloids – may lead to Raynaud's-like syndrome Cisplatin, oxygen, brentuximab – increases pulmonary toxicity Clozapine – increased risk of agranulocytosis Phenytoin – may reduce its absorption

+ Q. What precautions should I take while on Bleocin?

Inform your doctor if you have lung, heart, kidney, or liver issues. Regular chest X-rays are needed to monitor lung health. Avoid driving or using heavy machinery if feeling weak or tired. Inform your doctor if you have had chest radiation previously. Avoid using dextrose-containing solutions for reconstitution.

+ Q. Who should not take Bleocin?

Bleocin is contraindicated in: Patients with severe pulmonary disease or acute lung infections Pregnant or breastfeeding women Individuals allergic to bleomycin Patients receiving brentuximab, cisplatin, or high-concentration oxygen

+ Q. How is Bleocin administered?

Bleocin is given by a healthcare professional via: Intravenous (IV) injection Intramuscular (IM) injection Subcutaneous (SC) injection Intrapleural injection (for pleural effusion) Note: It must not be self-administered.

+ Q. Is there a lifetime dose limit for Bleocin?

Yes. The lifetime cumulative dose should not exceed 400 units due to the risk of pulmonary fibrosis.

+ Q. Can Bleocin be used during pregnancy or breastfeeding?

No. Bleocin is classified as Pregnancy Category D. It may cause harm to the fetus. Breastfeeding should be stopped during treatment due to the risk of serious side effects in the infant.

+ Q. What is the typical dose of Bleocin?

Squamous Cell Carcinoma, Testicular Carcinoma, Lymphomas: 0.25–0.5 units/kg (10–20 units/m²) once or twice weekly. Hodgkin’s Disease (after response): Maintenance dose of 1 unit daily or 5 units weekly. Initial test dose (1–2 units) is recommended for lymphoma patients due to potential allergic reactions.

+ Q. How does Bleocin work?

Bleocin is an anti-cancer agent that damages the DNA of cancer cells, causing them to stop multiplying and eventually die. It mainly inhibits DNA synthesis and causes single- and double-strand breaks in DNA.

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