✔ 100% Authentic Product
Giran-H Tablet 8 mg+12.5 mg (10pcs)
Manufacturer/Distributor: Aristopharma Limited
Generic Name: Candesartan Cilexetil 16 mg + Hydrochlorothiazide 12.5 mg Tablet
🛒 How to order this item?
✅ Description:
Indications
This is indicated for the treatment of hypertension, congestive heart failure.
Therapeutic Class
Combined antihypertensive preparations
Pharmacology
Candesartan Cilexetil-Hydrochlorothiazide combines an angiotensin II receptor blocker, Candesartan Cilexetil and a diuretic, Hydrochlorothiazide.
Candesartan Cilexetil is an ester prodrug that is hydrolysed in the body to the active form Candesartan during absorption from the gastrointestinal tract. Candesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues (eg, vascular smooth muscle, adrenal gland).
Hydrochlorothiazide is a thiazide diuretic. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly by increasing sodium excreation. Indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume with consequent increase in plasma renin activity, aldosterone secretion, urinary potassium loss, and decrease in serum potassium. The renin-aldosterone link is mediated by angiotensin II, so coadministration of Candesartan tends to reverse the potassium loss associated with Hydrochlorothiazide.
Dosage & Administration
The usual dose is one tablet once daily.
Interaction
No significant drug interactions have been reported for Candesartan Cilexetil with other drugs such as glyburide, nifedifine, digoxin, warfarin, hydrochlorothiazide and oral contraceptives. Alcohol, barbiturates, or narcotics- Potentiation of orthostatic hypotension may occur. Antidiabetic drugs (oral agents and insulin)- Dosage adjustment of the antidiabetic drug may be required. Other antihypertensive drugs- Additive effect or potentiation. Skeletal muscle relaxants, tubocurarine- Possible increased responsiveness to the muscle relaxant. NSAID can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.
Contraindications
Candesartan Cilexetil & Hydrochlorothiazide is contraindicated in patients who are hypersensitive to any component of this product. Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs.
Side Effects
Mild and transient in nature. The overall incidence of adverse events is comparable to placebo. Side effects are headache, upper respiratory tract infection, back pain, influenza-like symptoms.
Pregnancy & Lactation
Use in pregnancy & lactation is not recommended.
Precautions & Warnings
No patient receiving this combination was discontinued due to increases or decreases in serum potassium. Overall, the combination of candesartan cilexetil and hydrochlorothiazide had no clinically significant effect on serum potassium.
Use in Special Populations
Use in pediatric patient: Safety and effectiveness in pediatric patients have not been established.
Similar Products
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
Pricing Information, Availability:
ePharma reserves the right to make adjustments to pricing,
Products and Service offerings for reasons including, but not limited
to,
changing market conditions, Product discontinuation, Product
unavailability,
manufacturer price changes, supplier price changes and errors in
advertisements.
All orders are subject to Product availability and the availability of
Personnel to perform the Services.
Therefore, Seller cannot guarantee that it will be able to fulfill
Customer’s orders.
If Services are being performed on a time and materials basis, any
estimates provided
by Seller are for planning purposes only.
Reliable
All products displayed on ePharma are procured from govt. approved pharmaceuticals and verified licensed pharmacies from 2016.
Secure
ePharma uses Secure Sockets Layer (SSL) 128-bit 🔒 encryption and is Payment Card Industry DataSecurity Standard (PCI DSS) compliant.
Affordable
Find affordable medicine substitutes, save up to 50% on health products, up to 30% off on doctor consultations.
Social
Providing health care services under the health and beauty category with more than 170K Facebook audience and 10M+ reach.
Get more features!
Download the app now
- Pill reminder
- Prescription & Report
- Doctor consultation
- 24/7 helpline
