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Silcream 1% Cream 25gm
Silver Sulfadiazine cream is indicated for:
- Topical prophylaxis against bacterial colonization and infection in burn wounds.
- Topical antibacterial management of certain contaminated or infection-prone wounds, other than burns.
✅ Description:
Silcream 1% Cream is an antibiotic medication primarily used to treat bacterial and wound infections caused by serious burns. It is also effective in treating infected leg ulcers and pressure sores. Burns are classified based on their size and depth, ranging from minor to severe.
Silcream 1% Cream contains Silver Sulfadiazine, classified as a 'sulfa antibiotic.' It acts as a bactericidal agent, killing bacteria, and is also effective against yeast. By inhibiting the production of folic acid, essential for bacterial multiplication, and acting on the bacterial cell wall and membrane, it reduces the risk of bacterial spread and severe blood infections (sepsis).
Silcream 1% Cream is for external use only. Apply it to burn wounds continuously and cover the treated area with dressings or bandages if advised by your doctor.
Inform your doctor if you have glucose-6-phosphate dehydrogenase deficiency, low white blood cell count, or liver and kidney problems before using Silcream 1% Cream. If you are pregnant or planning to conceive, consult your doctor before using Silcream 1% Cream, as it may affect the unborn baby. Seek medical advice if you are breastfeeding before using Silcream 1% Cream.
Safety Advices
Alcohol
UNSAFE
The interaction of Silcream 1% Creamwith alcohol is unknown. Please consult a doctor before consuming alcohol while using Silcream 1% Cream.
Pregnancy
CONSULT YOUR DOCTOR
Limited information is available on how Silcream 1% Cream affects pregnancy. Consult a doctor if you are pregnant before using Silcream 1% Cream.
Breastfeeding
CONSULT YOUR DOCTOR
Consult your doctor before using Silcream 1% Cream if you are breastfeeding. However, if you need to apply SILVER SULFADIAZINE to your breasts, avoid doing so shortly before feeding your baby.
Driving
SAFE
Silcream 1% Cream is generally safe to use before driving. However, if you experience side effects like dizziness or a burning sensation in the affected areas, refrain from driving and operating machinery until you feel better.
Kidney
SAFE IF PRESCRIBED
Inform your doctor if you have any history of kidney diseases before using Silcream 1% Cream.
Liver
SAFE IF PRESCRIBED
Inform your doctor if you have any history of liver diseases before using Silcream 1% Cream.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses of Silcream 1% Cream
- Burn wound infections
✔️ How does Silcream 1% Cream work?
Silcream 1% Cream acts on the cell wall and cell membrane of the bacteria to cause their death.
✔️ Side Effects of Silcream 1% Cream
Transient leukopenia, skin necrosis, erythema multiform, skin discoloration, burning sensation, rashes, and interstitial nephritis.
✔️ Quick Tips:
- Silcream 1% Cream is meant for external use only.
- If the medicine is swallowed, seek immediate medical help.
- Follow all dosing instructions mentioned on the label or the package insert.
- Do not use this medicine for durations shorter or longer than recommended by your doctor.
- Ensure that the treatment course is completed.
- Report any undesired side effects to the doctor immediately.
- Do not stop the use of this medicine without consulting your doctor.
✔️ Indication of Silcream 1% Cream
Silcream 1% Cream is used for the prevention and treatment of wound infections in patients with second and third-degree burns.
✔️ Pharmacology
The mechanism of Silver Sulfadiazine's antibacterial action involves structural changes in bacterial cell membranes, including distortion and enlargement, weakening of the cell wall membrane, and reduced viability in sensitive strains. The silver moiety binds to bacterial cells, attaches to DNA, and prevents bacterial cell proliferation. Sulfadiazine provides bacteriostatic action against sensitive organisms.
✔️ Dosage of Silcream 1% Cream
Missed Dose
Use/apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.
Overdose
An overdose of Silcream 1% Cream is not likely to cause severe symptoms. However, ingestion of this medicine may cause harm and immediate medical intervention may be required.
✔️ Administration of Silcream 1% Cream
- Cleanse the burn wounds and apply Silver Sulfadiazine cream over the burn wound.
- Cover the burn areas with the cream at all times.
- Apply once to twice daily to a thickness of approximately 1/16 inches or 1.5 mm.
- Reapply whenever necessary, especially after hydrotherapy.
- Treatment should continue until satisfactory healing occurs or until the burn site is ready for grafting.
✔️ Interaction
- Silver sulfadiazine may inactivate enzymatic debriding agents, making concomitant use inappropriate.
- Potentiation of oral hypoglycemic agents and phenytoin action may occur, requiring monitoring of blood levels.
- Co-administration of Cimetidine may increase the incidence of leukopenia in patients with large-area burns.
✔️ Contraindications
- Hypersensitivity to Silver Sulfadiazine or any other ingredients in the preparation.
- Use on pregnant women approaching or at term, premature infants, or newborn infants during the first 2 months of life.
✔️ Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if justified. It is not known whether Silver Sulfadiazine is excreted in human milk.
✔️ Precautions & Warnings
- Monitor hepatic and renal functions in patients with impaired elimination.
- The possibility of silver inactivating topical proteolytic enzymes should be noted.
- Monitor serum sulfa concentrations in patients with extensive burn wounds.
- Renal function should be carefully monitored, and urine should be checked for sulfa crystals.
✔️ Storage Conditions:
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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