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Trialon IM/IA Injection
Triamcinolone acetonide 40mg/ml: i.m. Inj is indicated for short-term relief in cases of:
- Acute gouty arthritis
- Bursitis
- Osteoarthritis and rheumatoid arthritis with synovitis
- Epicondylitis
- Tenosynovitis
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✅ Description:
Trialon IM/IA Injection | Triamcinolone Acetonide 40 mg/ml
- Intramuscular Use:
When oral corticosteroids are not suitable, Trialon injection is indicated in the following conditions for systemic treatment: - Rheumatic Disorders: Short-term treatment during acute episodes of conditions such as acute gouty arthritis, acute rheumatic carditis, ankylosing spondylitis, psoriatic arthritis, and both adult and juvenile rheumatoid arthritis.
- Allergic Conditions: Severe or disabling allergies unresponsive to standard treatment, including asthma, atopic/contact dermatitis, drug allergies, serum sickness, seasonal or perennial allergic rhinitis, and transfusion reactions.
- Dermatological Disorders: Effective in severe skin conditions such as pemphigus, Stevens-Johnson syndrome, exfoliative erythroderma, dermatitis herpetiformis, and mycosis fungoides.
- Endocrine Disorders: Used in primary or secondary adrenocortical insufficiency (with mineralocorticoids if needed), congenital adrenal hyperplasia, hypercalcemia in malignancy, and subacute thyroiditis.
- Gastrointestinal Diseases: Helps manage critical phases of ulcerative colitis and Crohn’s disease.
- Hematological Disorders: Indicated in autoimmune hemolytic anemia, Diamond-Blackfan anemia, pure red cell aplasia, and certain cases of thrombocytopenia.
- Neoplastic Diseases: For palliative care in lymphomas and leukemias.
- Neurological Disorders: Acute flare-ups of multiple sclerosis, and management of cerebral edema due to brain tumors or surgery.
- Ophthalmic Conditions: For severe inflammatory eye diseases such as uveitis, sympathetic ophthalmia, and temporal arteritis.
- Renal Disorders: Used in idiopathic nephrotic syndrome and lupus nephritis for inducing remission.
- Respiratory Disorders: Treats conditions such as berylliosis, severe sarcoidosis, eosinophilic pneumonia, and disseminated tuberculosis (with anti-TB drugs).
- Miscellaneous: Indicated in trichinosis with systemic involvement and tuberculous meningitis (alongside anti-TB therapy).
✔️ Pharmacology
Triamcinolone Acetonide is a synthetic glucocorticoid with potent anti-inflammatory properties. This formulation is not water-soluble and is designed for intramuscular or intra-articular administration. It provides long-lasting effects, with adrenal suppression beginning within 24–48 hours post-dose and returning to normal within 30–40 days. Its mechanism includes reducing inflammation and modulating the immune response.
✔️ Side Effects
- Allergic: Anaphylaxis, angioedema
- Cardiovascular: Hypertension, arrhythmias, CHF
- Dermatologic: Acne, atrophy, purpura, rash
- Endocrine: Cushingoid features, menstrual irregularities, glucose intolerance
- GI: Peptic ulcers, pancreatitis, abdominal distension
- Musculoskeletal: Osteoporosis, muscle wasting, tendon rupture
- Neurological: Mood swings, psychosis, headache, increased intracranial pressure
- Ophthalmic: Cataracts, glaucoma, possible vision loss with periocular use
✔️ Dosage & Administration
General Use
- Initial dose: 2.5–100 mg/day, tailored to patient condition and severity.
- Strict aseptic technique is essential. Shake the vial well before use.
Intramuscular (Systemic)
- Typical adult dose: 60 mg deeply into the gluteal muscle.
- Range: 20–80 mg based on response and duration of effect.
- Pediatric dose: 0.11–1.6 mg/kg/day in 3–4 divided doses.
Intra-articular (Local)
- Smaller joints: 2.5–5 mg
- Larger joints: 5–15 mg, up to 40 mg
- Total maximum dose for multiple joints: up to 80 mg
Pediatric: Increased risk of adrenal suppression and growth delay.
Geriatric: May exhibit heightened sensitivity to side effects; monitor closely.
✔️ Drug Interactions
- Electrolyte depleters (e.g., diuretics, amphotericin B): Risk of hypokalemia and heart complications.
- Antidiabetics: May need dosage adjustments due to corticosteroid-induced hyperglycemia.
- Anticoagulants (e.g., warfarin): Monitor coagulation parameters closely.
- Macrolide antibiotics, ketoconazole, estrogens: May increase corticosteroid levels.
- Hepatic enzyme inducers may reduce the effectiveness of corticosteroids.
- NSAIDs: Increased GI risks; monitor for ulcers.
- Vaccines: Reduced vaccine efficacy and risk of infection from live vaccines.
- Cyclosporine: Enhanced toxicity; risk of convulsions.
✔️ Contraindications
Known hypersensitivity to triamcinolone or formulation components.
Not recommended for intramuscular use in idiopathic thrombocytopenic purpura.
✔️ Pregnancy & Lactation
Pregnancy Category C: Use only if benefits outweigh potential fetal risks.
Lactation: Corticosteroids may pass into breast milk and affect infant development. Use with caution in nursing mothers.
✔️ Precautions
- Use the lowest effective dose for the shortest duration.
- Taper dosage gradually to prevent adrenal insufficiency.
- Monitor for psychiatric symptoms, increased intraocular pressure, bone demineralization, and GI bleeding.
- Avoid intra-articular injection in infected joints. Confirm asepsis before administration.
- Special care in cardiac, renal, diabetic, and osteoporotic patients.
✔️ Storage Conditions
Store below 25°C.
Keep away from light and freezing.
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information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
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