Capsule. Generic Name: Tramadol hydrochloride 50mg Manufacturer/Distributor: Sandoz/Novartis
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Doloran 50mg/ Tramadol hydrochloride 50mg is a medication that is used to treat moderate to severe pain. It belongs to the class of drugs known as opioid analgesics, which work by binding to opioid receptors in the brain and reducing the perception of pain.
Doloran 50mg/ Tramadol hydrochloride is available in various forms, including tablets, capsules, and oral drops. The 50mg dose is a commonly prescribed strength. The medication is usually taken every four to six hours as needed for pain relief.
While tramadol hydrochloride is an effective pain reliever, it also has the potential for abuse and dependence. As such, it is classified as a Schedule IV controlled substance in the United States. It is important to take tramadol hydrochloride exactly as prescribed by a healthcare provider and not to exceed the recommended dose.
Doloran 50mg/ Tramadol hydrochloride may interact with other medications or substances, including alcohol, benzodiazepines, and antidepressants. It is important to inform a healthcare provider of all medications being taken before starting tramadol hydrochloride.
Dosage & Administration of Doloran 50mg
Capsule or Tablet: Usual doses are 50 to 100 mg every four to six hours. For acute pain an initial dose of 100 mg is required. For chronic painful conditions an initial dose of 50 mg is recommended. Subsequent doses should be 50 to 100 mg administered 4-6 hourly. The dose level and frequency of dosing will depend on the severity of the pain.The total daily dosage by mouth should not exceed 400 mg.
Sustained Release Capsule or Tablet: One SR capsule or tablet every 12 hours, for example first one in the morning and then at the same time in the evening. The number of capsules taken at a time will depend upon severity of pain, but it should not be taken more frequently than every 12 hours.The total daily dosage by mouth should not exceed 400 mg.
Injection: A dose of 50-100 mg may be given every 4 to 6 hours by intramuscular or by intravenous infusion. For the treatment of postoperative pain,the initial dose is 100 mg followed by 50 mg every 10 to 20 minutes if necessary to a maximum of 250 mg in the first hour. Thereafter, doses are 50 to 100 mg every 4 to 6 hours up to a total daily dose of 600 mg.
Suppository: Tramadol suppository should be administered rectally. For adults usual dose is 100 mg Tramadol Hydrochloride 6 hourly. In general, 400 mg Tramadol Hydrochloride (4 Tramadol suppository) per day sufficient. However, for the treatment of Cancer pain and severe pain after operations much higher daily doses can be used.
Interaction of of Doloran 50mg
In general, there are no medicines that interact with Tramadol that doctors should be concerned about. Monoamine oxidase (MAO) inhibitors are the only pharmacological class that should not be used in conjunction with Tramadol. The combination of carbamazepine and Tramadol induces a considerable increase in Tramadol metabolism, necessitating an increase in Tramadol dosage.
Contraindications of Doloran 50mg
People who are hypersensitive to tramadol should avoid using it. Intoxication with alcohol, hypnotics, centrally acting analgesics, opioids, or psychotropic medications is also contraindicated.
Precautions & Warnings of Doloran 50mg
Respiratory depression: When large doses of tramadol are used together with narcotic drugs or alcohol, it can cause respiratory depression. Therefore, patients at risk of respiratory depression should use tramadol with caution.
Opioid dependence: Tramadol is not recommended for patients who are dependent on opioids.
Concomitant central nervous system depressants: Tramadol should be used with caution and dose reduced when administered to patients receiving central nervous system depressants (such as alcohol, opioids, anesthetics, phenothiazines, sedatives, or sedative-hypnotics).
Concomitant MAO inhibitors: Patients taking MAO inhibitors should use tramadol with caution, as tramadol inhibits norepinephrine and serotonin uptake.
Tramadol should be used with caution in patients with elevated intracranial pressure or head trauma and patients with acute abdomen.
Therapeutic Class
Opioid analgesics
Side effects of Doloran 50mg/ tramadol hydrochloride may include dizziness, nausea, constipation, and drowsiness. More serious side effects, such as difficulty breathing or an allergic reaction, require immediate medical attention.
Pregnancy & Lactation
Tramadol has not been proven to be safe during pregnancy. It has been proven that tramadol crosses the placenta. In pregnant women, there are no sufficient and well-controlled trials. Tramadol should therefore only be used during pregnancy if the possible benefit outweighs the risk to the fetus. Because tramadol and its metabolites have been found in breast milk, Tramadol Hydrochloride should not be given to a nursing mother.
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