Syndopa CR 250mg Tablet is a combination of two medicines: Levodopa and Carbidopa. This medication is used to treat the symptoms of Parkinson's disease like tremors (shaking), stiffness, and slowness of movement. These symptoms are caused due to the lack of dopamine, a natural substance usually found in the brain.
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Consumption of alcohol is not recommended during treatment with Syndopa CR 250 Tablet as it may increase the risk of side effects like depression and impairment of judgment, thinking, and psychomotor skills.
Syndopa CR 250 Tablet is generally not recommended for use during pregnancy as animal studies indicate that it may harm the developing fetus. Hence, consult your doctor if you are pregnant.
Syndopa CR 250 Tablet is not recommended for use while breastfeeding as it is not known if this medicine passes into breast milk. Consult your doctor if you are breastfeeding.
Avoid driving vehicles or operating machines after taking this medicine, as it can make you feel dizzy.
Syndopa CR 250 Tablet should be used with caution if you have kidney problems as this medicine is filtered and excreted through your kidneys. If your kidneys are not working properly, it may lead to the accumulation of this medicine in the body and increase the risk of undesired effects. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your clinical condition.
Syndopa CR 250 Tablet should be used with extreme caution if you have liver problems as this medicine is broken down in the liver. If your liver is not working properly, it may cause an accumulation of this medicine, resulting in toxicity. Your doctor may suggest tests to monitor your liver function while you are taking this medicine.
Levodopa works by being converted to dopamine in the brain. Carbidopa works by preventing levodopa from being broken down before it reaches the brain.
By increasing the amount of dopamine in the brain, Levodopa+Carbidopa helps control the symptoms of Parkinson’s disease and helps you to perform daily activities such as dressing, walking, handling utensils, etc.
Syndopa CR 250mg Tablet is prescribed for the treatment of Parkinson's disease and Parkinson's syndrome. It alleviates symptoms such as rigidity and bradykinesia, and it also helps with tremors, difficulty swallowing, excessive saliva, and postural instability. Additionally, it improves motor recovery after a stroke when used prior to physiotherapy.
Levodopa and carbidopa are combined to treat Parkinson's disease and symptoms similar to Parkinson's that result from encephalitis or poisoning by carbon monoxide or manganese. Parkinson's symptoms like tremors, stiffness, and slow movement are due to a dopamine deficiency in the brain. Levodopa, a central nervous system agent, converts into dopamine in the brain. Carbidopa, a decarboxylase inhibitor, prevents the breakdown of levodopa before it reaches the brain, allowing for lower doses and reducing side effects like nausea and vomiting.
For patients switching from conventional levodopa/decarboxylase inhibitor combinations: Start with a dose that is no more than 10% higher than the current daily levodopa intake, especially for those taking more than 900 mg per day. Increase the interval between doses by 30-50%, ranging from 4 to 12 hours. Smaller doses, if divided unequally, should be taken later in the day. Dosages may need further adjustment based on clinical response, potentially increasing up to 30%.
Conversion from conventional to controlled-release tablets:
For patients previously on levodopa alone: Discontinue levodopa at least 8 hours before starting this controlled-release medication. For mild to moderate disease, start with one tablet twice daily.
For patients not on levodopa: For mild to moderate disease, start with one tablet twice daily. Initial doses should not exceed 600 mg of levodopa per day, nor be administered at intervals of less than six hours.
Titration: Adjust doses and intervals based on therapeutic response. Most patients respond well to 2-8 tablets per day, in divided doses every 4-12 hours. Higher doses and shorter intervals can be used but are not usually recommended. An interval of at least three days between adjustments is advised.
Maintenance: Regular clinical evaluations are needed to adjust the dosage as Parkinson’s disease progresses.
Addition of other medications: Anticholinergic agents, dopamine agonists, and amantadine can be used with this medication, but dosage adjustments may be necessary.
Interruption of therapy: Monitor patients closely if abrupt reduction or discontinuation is needed, especially if they are on antipsychotics.
Introducing carbidopa-levodopa in patients on antihypertensives may cause postural hypotension, requiring adjustments in antihypertensive dosages. Combining with tricyclic antidepressants can lead to hypertension and dyskinesia. Iron supplements may reduce the bioavailability of carbidopa and levodopa. Dopamine-2 receptor antagonists and some other medications can diminish levodopa’s effects. Combining with selegiline may cause severe orthostatic hypotension.
Avoid in patients with hypersensitivity to the components, narrow-angle glaucoma, suspicious skin lesions, or a history of melanoma.
The effects on human pregnancy are unknown, but animal studies suggest potential risks. Carbidopa and levodopa should only be used in women of childbearing age when the benefits outweigh the risks. The excretion of carbidopa in human milk is unclear; caution is advised due to potential adverse reactions in nursing infants.
Store in a cool, dry place, protected from light.
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