Neoral 25mg Capsule | Uses | Dosage | FAQ | Price | ePharma
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Neoral 25mg Capsule

Generic: Cyclosporin

Type: Capsule

Pack Size: 5 Pcs

Ciclosporin is used for the prevention of organ rejection in transplant patients, rheumatoid arthritis, psoriasis, bone marrow transplantation, nephrotic syndrome, uveitis, and Atopic dermatitis.


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Discount Price: ৳ 281.44
MRP: ৳ 296.25 5% Off

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✅ Description:

Sandummun Neoral 50mg Capsule and its active ingredient, Cyclosporine. It's clear that this medication is used as an immunosuppressant primarily to prevent organ rejection in patients who have undergone solid organ transplantation. Here's a breakdown of the key points:

  • Sandummun Neoral 50mg Capsule contains the active ingredient Cyclosporine, which is an immunosuppressant drug used to prevent organ rejection after solid organ transplantation (e.g., kidney, liver, heart).
  • After transplantation, the body's immune system can attack the transplanted organ since it recognizes it as foreign. Immunosuppressants like Cyclosporine suppress this immune response, helping to prevent organ rejection.
  • Immunosuppressants, including Cyclosporine, can increase the risk of skin cancer. Patients taking this medication are advised to limit sun exposure, wear protective clothing, and use sunscreen with a high sun protection factor (SPF).
  • Patients who have recently received live vaccines should inform their physician, as immunosuppressants can affect vaccine effectiveness and safety.
  • Individuals with known hypersensitivity or allergy to Sandummun Neoral 50mg Capsule or its components should not use this medication.
  • Cyclosporine can raise blood pressure levels. It should be used cautiously or avoided in individuals with uncontrolled high blood pressure or a history of hypertension.
  • Patients, especially those planning to conceive, should discuss potential reproductive effects with a healthcare professional before taking this medication.
  • Monitoring for diabetes is important, particularly for individuals who are at risk.

Safety Advices


Alcohol
UNSAFE

Avoid consumption of alcohol while taking Neoral 25mg Capsule as it might worsen your condition.


Pregnancy
CONSULT YOUR DOCTOR

If you are taking Sandummun Neoral 25mg Capsule and are planning to become pregnant or are already pregnant, it is important to discuss this with your healthcare professional.


Breastfeeding
UNSAFE

Neoral 25mg Capsule may pass through the breast milk. Therefore, it is not recommended for use in breastfeeding women. However, consult your doctor before taking it.


Driving
CAUTION

Do not drive or operate any heavy tools or machines if your ability is affected by Neoral 25mg Capsule.


Kidney
CONSULT YOUR DOCTOR

Neoral 25mg Capsule is not recommended for use in patients with other kidney problems (except for nephrotic syndrome). Therefore, consult your doctor before taking it.


Liver
CONSULT YOUR DOCTOR

Neoral 25mg Capsule should be used with caution in patients with liver problems (including Hepatitis C infection). Therefore, consult your doctor before taking it.

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✔️ Uses of Neoral 25mg Capsule
  • Prevents graft rejection following organ transplantation
  • Treats auto-immune skin diseases such as psoriasis or atopic dermatitis
  • Treats rheumatoid arthritis (joint inflammation)
  • Treat nephrotic syndrome (a kidney disease)
  • Treats eye inflammation (such as endogenous uveitis, including Behçet's uveitis)
✔️ How does Neoral 25mg Capsule work?

Ciclosporin is an immunosuppressive agent that blocks the release of specific immune-triggering chemicals like T-cells, interleukins, and cytokines. By doing so, it suppresses the immune system, helping the body accept a newly transplanted organ. Additionally, it halts abnormal immune responses and prevents the body from attacking its own cells.

✔️ Side Effects of Neoral 25mg Capsule
  • Irritability
  • Muscle tremor
  • Change in mood
  • Nightmares
  • Anxiety
  • Dizziness and Drowsiness
  • Mental depression
  • Nervousness
  • Headache
✔️ Quick Suggestions:
  • Ciclosporin is used to prevent organ rejection in transplant patients.
  • It is also used to treat arthritis and immune disorders of the eyes, lungs, muscles, skin, nerves, and blood vessels.
  • It may take 3 to 4 months for the medication to work. Keep taking it as prescribed.
  • Your doctor may get regular blood tests done to check the levels of blood cells in your blood. Inform your doctor if you experience unexplained bruising or bleeding, sore throat, mouth ulcers, fever, or general illness. 
  • Your doctor may monitor your kidney function regularly. Drink 8 to 10 glasses of water per day to help with your kidney function.
  • Do not stop taking Ciclosporin without talking to your doctor first.
✔️ Indication of Neoral 25mg Capsule

Ciclosporin serves several medical purposes, including:

  • Preventing Graft Rejection: It is used to prevent the rejection of transplanted organs.
  • Treating Auto-Immune Skin Diseases: Cyclosporine is used to manage conditions like psoriasis and atopic dermatitis, which are characterized by an overactive immune response targeting the skin.
  • Treating Rheumatoid Arthritis: It's effective in treating joint inflammation associated with rheumatoid arthritis, helping to alleviate symptoms and manage the condition.
  • Treating Nephrotic Syndrome: Used in the treatment of nephrotic syndrome, a kidney disorder characterized by high levels of protein in the urine, swelling, and other complications.
  • Treating Eye Inflammation: Cyclosporine is employed in cases of eye inflammation, including conditions like endogenous uveitis and Behçet's uveitis, to alleviate inflammation and manage symptoms.

These applications highlight the versatility of Cyclosporine in addressing various immune-related conditions and maintaining the health of different organs and systems in the body.

✔️ Pharmacology

Cyclosporine forms a complex with cyclophilin. This complex goes on to inhibit calcineurin, a protein that typically triggers the activation of interleukin 2 transcription. Additionally, Cyclosporine hampers the production of lymphokines and the release of interleukins. In ophthalmic applications, the exact mechanism isn't fully understood. In the context of patients with reduced tear production due to ocular inflammation related to keratoconjunctivitis sicca, Cyclosporine emulsion is believed to function as a partial immunomodulator.

✔️ Dosage & Administration of Neoral 25mg Capsule

Dosages for Neoral 25mg Capsule in different medical conditions are as follows:

Solid Organ Transplantation:

  • Initially, 10 to 15 mg/kg is given in 2 divided doses, starting 12 hours before surgery.
  • Continue for 1 to 2 weeks post-operatively.
  • Maintenance dose: Gradually adjust to 2 to 6 mg/kg in 2 divided doses.

Bone Marrow Transplantation:

  • Initially, 12.5 to 15 mg/kg is given in 2 divided doses, starting a day before transplantation.
  • Maintain 12.5 mg/kg in 2 divided doses for 3 to 6 months.
  • Gradually decrease to zero by 1 year after transplantation.

Endogenous Uveitis:

  • Start with 5 mg/kg per day orally in 2 divided doses.
  • Gradually reduce for maintenance treatment.

Nephrotic Syndrome:

  • Initially, 5 mg/kg for adults and 6 mg/kg for children in 2 divided doses.
  • Lower initial dose for renal impairment.
  • Gradually decrease to the lowest effective level for maintenance.

Rheumatoid Arthritis:

  • First 6 weeks: 3 mg/kg per day in 2 divided doses.
  • Up to 12 weeks may be needed for full effectiveness.
  • Adjust maintenance dose based on tolerability.

Psoriasis & Atopic Dermatitis:

  • Start with 2.5 mg/kg per day in 2 divided doses.
  • Use 5 mg/kg per day for rapid improvement cases.
  • Titrate maintenance dose to the lowest effective level.

Directions for Use:

  • Take Neoral 25mg Capsule as prescribed by your doctor.
  • Swallow with a glass of water; do not crush or chew.
  • Dosing is determined by your age, weight, and disease.
  • Do not stop treatment without consulting your doctor.

Always follow your healthcare professional's instructions for accurate dosing and proper use of Neoral 25mg Capsule.

✔️ Interaction

Drug-Drug Interactions: Cyclosporine can interact with various other medications, including:

  • Immunosuppressants like tacrolimus
  • Anti-gout drugs like thiopurine
  • Diuretics (water pills) like amiloride, spironolactone
  • Blood pressure-lowering medications like Aliskiren
  • Cholesterol-lowering drugs like atorvastatin, pitavastatin, simvastatin
  • Antibiotics like erythromycin or azithromycin
  • Antifungal medications like voriconazole, itraconazole
  • Heart and blood pressure medications like diltiazem, verapamil, amiodarone
  • Medications for menstrual problems like danazol
  • Gout treatment drugs like allopurinol
  • Hepatitis C treatment medications like colchicine, and telaprevir.

Drug-Food Interaction: Avoid consuming grapefruit or grapefruit juice while taking Cyclosporine, as it can impact the effectiveness of the medication.

Drug-Disease Interactions: Cyclosporine might interact with certain disease conditions:

  • High blood pressure
  • Liver disease
  • Kidney disease
✔️ Contraindications

Neoral 25mg Capsule is not recommended for use in the following situations:

  • Colitis: Inflammation of the intestine.
  • Peripheral Neuropathy: Numbness and pain in hands and feet due to nerve damage.
  • Porphyria: A condition involving an accumulation of porphyrin, a substance involved in making hemoglobin.
  • Hemodialysis: Undergoing kidney dialysis treatment.
  • Diabetes: Having diabetes.
  • Gout: Experiencing high levels of uric acid.
  • Liver Toxicity: Suffering from liver damage.
  • Optic Neuritis: Having vision problems related to optic nerve inflammation.
  • Kidney Dysfunction: Experiencing impaired kidney function.
  • Liver Dysfunction: Having impaired liver function.
  • Allergy: Being allergic to the medicine.
✔️ Pregnancy & Lactation

Pregnancy: There are no adequate and well-controlled studies in pregnant women and, therefore, Cyclosporine should not be used during pregnancy unless the potential benefit to the mother justifies the potential risk to the fetus.

Lactation: Cyclosporine passes into breast milk. Mothers receiving treatment with Cyclosporine should not breastfeed.

✔️ Precautions & Warnings
  • Avoid taking Cyclosporine if you have an allergy to any of its components. Prior to using Cyclosporine, inform your doctor about conditions such as liver or kidney problems, high blood pressure, low magnesium levels, and elevated potassium levels.
  • Be aware that Cyclosporine might increase your susceptibility to infections. Contact your doctor if you experience severe symptoms like fever, sore throat, difficulty breathing, jaundice, unexplained bleeding, or bruising.
  • If you have any type of cancer, inform your doctor before taking Cyclosporine. If you are pregnant or planning pregnancy, refrain from using Cyclosporine. Breastfeeding mothers should also avoid it, as it can pass into breast milk.
  • Discuss your health status and medication use with your doctor to prevent potential adverse effects. Your doctor can help ensure your safety and well-being while using Cyclosporine.
✔️ Storage Conditions

Store the Neoral 25mg Strip of 5 Capsules in a secure location inaccessible to toddlers or pets. Choose a well-ventilated room to prevent damage from heat and humidity. Refer to the label on the Neoral 25mg Strip of 5 Capsules for additional instructions.

✔️ Disposal

Properly dispose of the medicine if it's no longer needed, ensuring it doesn't pose any risk to others. Disposal guidelines provided on the packaging should be followed.

Frequently Asked Questions (FAQ)

If you miss a dose of Neoral 25mg Capsule, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and take the scheduled dose instead.

Neoral 25mg Capsule might interfere with live bacterial vaccines and cause them not to work. Do not take any immunizations /vaccinations while on Neoral 25mg Capsule unless you are asked to.

No

Prior to taking Neoral 25mg Capsule, notify your doctor about liver issues, signs of infections (like fever or sore throat), hepatitis C infection, seizures, low blood magnesium, gout, alcohol dependence, severe uncontrollable infections, various types of cancer, severe high blood pressure, or upcoming vaccinations. If you are pregnant or breastfeeding, inform your doctor beforehand.

No
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Check our pricing section for Neoral 25mg Capsule price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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