Neoral 50mg Capsule | Uses | Side-Effects | Quick Suggestion | ePharma
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Neoral 50mg Capsule

Generic: Cyclosporin

Type: Capsule

Pack Size: 5 Pcs

Ciclosporin is used for the prevention of organ rejection in transplant patients, rheumatoid arthritis, psoriasis, bone marrow transplantation, nephrotic syndrome, uveitis, and Atopic dermatitis.


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Discount Price: ৳ 570
MRP: ৳ 600 5% Off

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✅ Description:

  • Neoral 50mg Capsule is utilized for tuberculosis (TB) treatment when other drugs are ineffective, often in combination with other medications. It's also effective against urinary tract infections. Considered a second-line drug, it's employed after initial treatments fail. This antibiotic restricts bacterial growth by inhibiting cell wall biosynthesis, making it unsuitable for viral problems.
  • Possible side effects include headache, drowsiness, dizziness, tremors, swelling (especially ankles and feet), pale skin, etc. Although it's generally safe when used correctly, any symptoms should be promptly reported to a doctor. Some individuals might experience sleepiness, unsteadiness, numbness, or occasional seizures.
  • Neoral 50mg Capsule is listed in the World Health Organization's Essential Medicines as effective and safe.
  • Remember, individual responses may vary. Consulting an Internal Medicine Specialist before use is advised based on the medicine's salt content, and its effects can differ from person to person.

Safety Advices


Alcohol
UNSAFE

It is unsafe to drink alcohol while taking Neoral 50mg Capsules. It may reduce the drug's effectiveness and can cause toxic side effects.


Pregnancy
CONSULT YOUR DOCTOR

If you are taking Neoral 50mg Capsule and are planning to become pregnant or are already pregnant, it is important to discuss this with your healthcare professional.


Breastfeeding
UNSAFE

Neoral 50mg Capsule can pass into breast milk. Mothers receiving treatment with it should not breastfeed.


Driving
CAUTION

Neoral 50mg Capsule can cause dizziness. It is recommended to avoid driving and operating heavy machinery during the treatment. 


Kidney
CONSULT YOUR DOCTOR

Neoral 50mg Capsule is not recommended for use in patients with other kidney problems (except for nephrotic syndrome). Therefore, consult your doctor before taking it.


Liver
CONSULT YOUR DOCTOR

Neoral 50mg Capsule should be used cautiously in individuals with liver impairment or pre-existing liver disease. This is because this medication is primarily metabolized in the liver, and impaired liver function can affect the metabolism and clearance of the medication from the body 

Similar Products

✔️ Uses of Neoral 50mg Capsule
  • Organ Transplant - Rejection Prophylaxis
  • Rheumatoid Arthritis
  • Psoriasis
✔️ How does Neoral 50mg Capsule work?
  • Neoral 50mg Capsule works by blocking the cytokine genes in the T cells that are activated. It forms a complex with Cyclophilin and inhibits the activity of Calcineurin which helps regulate nuclear translocation. It also blocks the pathways that are triggered by antigens.
✔️ Side Effects of Neoral 50mg Capsule

Common Side Effects:

  • High blood pressure
  • Headache and shakiness
  • Nausea, vomiting, loss of appetite, stomach pain, diarrhea
  • Acne, hot flushes, fever, tiredness
  • Excessive facial hair
  • Elevated blood cholesterol and sugar levels
  • Tingling sensation in the body
  • Muscle spasms, swollen gums
  • Elevated levels of uric acid or potassium
  • Low levels of magnesium in the blood

Uncommon Side Effects:

  • Insomnia (lack of sleep)
  • Edema and weight gain

Rare Side Effects:

  • Inflammation of the pancreas, severe upper stomach pain
  • Menstrual irregularities, breast enlargement in men

Serious Side Effects (Stop Taking and Contact Your Doctor Immediately):

  • Signs of infection (fever or sore throat)
  • Signs of brain infection known as progressive multifocal leukoencephalopathy (vision changes, loss of coordination, memory loss, etc.)
  • Brain-related problems (seizures, confusion, paralysis, etc.)
  • Swelling at the back of the eye with blurred vision
  • Signs of liver problems (yellow skin/eyes, nausea, dark urine)
  • Low urine output, kidney issues
  • Low red blood cells or platelet levels (pale skin, fatigue, breathlessness, bruising/bleeding, confusion, kidney problems)

These are potential side effects associated with Neoral 50mg Capsule. If you experience any of the serious side effects, consult your doctor immediately.

✔️ Quick Suggestions:
  • Consume foods rich in quercetin (e.g., apples, cherries, broccoli, spinach, blueberries), a flavonoid with potential anti-allergic properties.
  • Incorporate foods rich in probiotics to support the immune system against allergies.
  • Limit intake of potential allergy triggers like dairy products, soy, eggs, and nuts.
  • Avoid excessive sugar consumption to prevent inflammation flare-ups.
  • Ciclosporin is used to prevent organ rejection in transplant patients.
  • It treats various immune-related conditions involving the eyes, lungs, muscles, skin, nerves, and blood vessels.
  • The medication might take several months to show its full effects; continue taking it as prescribed.
  • Regular blood tests may be performed to monitor blood cell levels.
  • Report any unusual symptoms such as bruising, bleeding, sore throat, mouth ulcers, fever, or general illness to your doctor.
  • Kidney function should be monitored; stay hydrated by drinking 8 to 10 glasses of water daily.
  • Never stop taking Ciclosporin without consulting your doctor.
  • Opt for a diet rich in fruits, vegetables, whole grains, healthy fats, and fish.
  • Manage stress and maintain a consistent sleep schedule.
  • Avoid harsh soaps, detergents, and rough fabrics that could irritate the skin.
✔️ Indication

Organ Transplant Rejection: After receiving a new organ through transplantation, the body's immune system may identify it as foreign and attempt to attack and reject it. This occurs because the transplanted organ's antigens are different from the recipient's own antigens. To prevent this rejection, immunosuppressant drugs like cyclosporine are administered. These drugs suppress the immune response, reducing the chances of the body attacking the newly transplanted organ.

Rheumatoid Arthritis: Rheumatoid arthritis is an autoimmune disorder where the body's immune system mistakenly targets and attacks its own joint tissues. This leads to inflammation, pain, swelling, and damage to the joints. The symptoms can result in difficulty moving and reduced joint function.

Psoriasis: Psoriasis is a chronic inflammatory skin condition characterized by the development of itchy and red patches on the skin. Although not contagious, it often has a genetic predisposition. The immune system plays a role in triggering excessive skin cell growth, causing the buildup of patches and scales on the skin's surface.

✔️ Pharmacology

Cyclosporine binds to a protein called cyclophilin. This complex goes on to inhibit calcineurin, which is a key enzyme responsible for activating the transcription of interleukin 2 (IL-2), an important cytokine involved in immune responses. By inhibiting calcineurin, Cyclosporine prevents the production of IL-2 and also hinders the release of other immune-signaling molecules.

✔️ Dosage & Administration of

Adult Dose:

  • For organ transplantation: Initial doses vary (10-15 mg/kg/day), followed by maintenance doses (2-6 mg/kg/day).
  • Severe atopic dermatitis and psoriasis: Initial dose (2.5 mg/kg/day) in divided doses, with adjustments based on response.
  • Rheumatoid arthritis: 2.5 mg/kg/day in divided doses, with potential dose increase.
  • Nephrotic syndrome: 5 mg/kg daily in divided doses.

Child Dose:

  • Nephrotic syndrome in children: 6 mg/kg daily in divided doses.

Administration:

  • Cyclosporine can be taken with or without food. Consistency in timing and relation to meals is important.
  • Grapefruit juice should be avoided.
✔️ Interaction

Medications that Increase Cyclosporine Levels:

  • Diltiazem, doxycycline, erythromycin, ketoconazole, methylprednisolone (high doses), nicardipine, verapamil, and oral contraceptives can increase Cyclosporine levels in the body.

Medications that Reduce Cyclosporine Levels:

  • Carbamazepine, isoniazid, phenobarbitone, phenytoin, and rifampicin can decrease Cyclosporine levels.

Interaction with Methylprednisolone:

  • Concurrent use of high-dose methylprednisolone with Cyclosporine can increase the risk of convulsions.

Potentially Fatal Interactions (Additive Nephrotoxicity):

  • Cyclosporine use in combination with aminoglycosides, amphotericin B, ciprofloxacin, colchicine, melphalan, co-trimoxazole, and NSAIDs can lead to additive nephrotoxicity, potentially causing serious kidney damage.
✔️ Contraindications

Hypersensitivity to Cyclosporine or to any of the excipients of Cyclosporine.

✔️ Pregnancy & Lactation

Pregnancy: There are no adequate and well-controlled studies in pregnant women and, therefore, Cyclosporine should not be used during pregnancy unless the potential benefit to the mother justifies the potential risk to the fetus.

Lactation: Cyclosporine passes into breast milk. Mothers receiving treatment with Cyclosporine should not breastfeed.

✔️ Precautions & Warnings
  • Cyclosporine increases the risk of developing lymphomas and other malignancies, especially skin cancers. Patients should avoid excessive ultraviolet light exposure and take measures to protect their skin.
  • Cyclosporine may lead to bacterial, fungal, parasitic, and viral infections. Long-term immunosuppressive strategies are important to manage the risk of infections.
  • A reversible increase in serum creatinine and urea might occur initially and often responds to dose reduction. Elderly patients, in particular, require careful renal function monitoring.
  • Blood pressure should be regularly monitored during Cyclosporine therapy. If hypertension develops, appropriate antihypertensive treatment should be administered.
  • Cyclosporine enhances the risk of hyperkalemia, especially in patients with renal dysfunction. Caution is advised when co-administered with potassium-sparing drugs. It also affects magnesium clearance, necessitating potential supplementation.
  • Care should be taken when treating patients with hyperuricemia (elevated uric acid levels in the blood).
  • During Cyclosporine treatment, the efficacy of vaccinations may be reduced, and live-attenuated vaccines should be avoided.
  • Non-transplant patients with impaired renal function, uncontrolled hypertension, uncontrolled infections, or any kind of malignancy should not receive Cyclosporine.
  • Contraindications include renal and hepatic impairment, hyperuricemia, history of allergic reactions, anaphylaxis, pregnancy, and lactation.
  • Cyclosporine is excreted in breast milk; nursing should be avoided.
✔️ Storage Conditions

Store in a cool and dry place away from sunlight

Frequently Asked Questions (FAQ)

Neoral 50mg Capsule acts as an immunosuppressant, which helps in reducing inflammation and prevents joint stiffness, thereby provides relief from rheumatoid arthritis.

You need to take Neoral 50mg Capsule for the stipulated duration prescribed by your doctor. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

It is not known when Sandimmun Neoral 50 mg Capsule will start its action.

Neoral 50mg Capsule may remain in your body for around 2-3 days.

Regular monitoring of blood pressure is important while taking Sandummun Neoral 50mg Capsule. If your blood pressure increases significantly, your healthcare professional may recommend lifestyle modifications such as dietary changes, exercise, and, in some cases, medication to control hypertension.

Neoral 50mg Capsule is linked to a higher risk of specific cancers, including skin cancers and lymphomas. Regular skin checks are vital, and any unusual growths or changes should be promptly reported to your healthcare provider. They will monitor for cancer signs and offer appropriate care.
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Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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