Ciclosporin is used for the prevention of organ rejection in transplant patients, rheumatoid arthritis, psoriasis, bone marrow transplantation, nephrotic syndrome, uveitis, and Atopic dermatitis.
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It is unsafe to drink alcohol while taking Neoral 50mg Capsules. It may reduce the drug's effectiveness and can cause toxic side effects.
If you are taking Neoral 50mg Capsule and are planning to become pregnant or are already pregnant, it is important to discuss this with your healthcare professional.
Neoral 50mg Capsule can pass into breast milk. Mothers receiving treatment with it should not breastfeed.
Neoral 50mg Capsule can cause dizziness. It is recommended to avoid driving and operating heavy machinery during the treatment.
Neoral 50mg Capsule is not recommended for use in patients with other kidney problems (except for nephrotic syndrome). Therefore, consult your doctor before taking it.
Neoral 50mg Capsule should be used cautiously in individuals with liver impairment or pre-existing liver disease. This is because this medication is primarily metabolized in the liver, and impaired liver function can affect the metabolism and clearance of the medication from the body
Common Side Effects:
Uncommon Side Effects:
Rare Side Effects:
Serious Side Effects (Stop Taking and Contact Your Doctor Immediately):
These are potential side effects associated with Neoral 50mg Capsule. If you experience any of the serious side effects, consult your doctor immediately.
Organ Transplant Rejection: After receiving a new organ through transplantation, the body's immune system may identify it as foreign and attempt to attack and reject it. This occurs because the transplanted organ's antigens are different from the recipient's own antigens. To prevent this rejection, immunosuppressant drugs like cyclosporine are administered. These drugs suppress the immune response, reducing the chances of the body attacking the newly transplanted organ.
Rheumatoid Arthritis: Rheumatoid arthritis is an autoimmune disorder where the body's immune system mistakenly targets and attacks its own joint tissues. This leads to inflammation, pain, swelling, and damage to the joints. The symptoms can result in difficulty moving and reduced joint function.
Psoriasis: Psoriasis is a chronic inflammatory skin condition characterized by the development of itchy and red patches on the skin. Although not contagious, it often has a genetic predisposition. The immune system plays a role in triggering excessive skin cell growth, causing the buildup of patches and scales on the skin's surface.
Cyclosporine binds to a protein called cyclophilin. This complex goes on to inhibit calcineurin, which is a key enzyme responsible for activating the transcription of interleukin 2 (IL-2), an important cytokine involved in immune responses. By inhibiting calcineurin, Cyclosporine prevents the production of IL-2 and also hinders the release of other immune-signaling molecules.
Adult Dose:
Child Dose:
Administration:
Medications that Increase Cyclosporine Levels:
Medications that Reduce Cyclosporine Levels:
Interaction with Methylprednisolone:
Potentially Fatal Interactions (Additive Nephrotoxicity):
Hypersensitivity to Cyclosporine or to any of the excipients of Cyclosporine.
Pregnancy: There are no adequate and well-controlled studies in pregnant women and, therefore, Cyclosporine should not be used during pregnancy unless the potential benefit to the mother justifies the potential risk to the fetus.
Lactation: Cyclosporine passes into breast milk. Mothers receiving treatment with Cyclosporine should not breastfeed.
Store in a cool and dry place away from sunlight
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