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Psoriasis is a chronic, non-communicable, and debilitating disease characterized by the rapid growth of skin cells, resulting in red, scaly patches. It can occur at any age but is most prevalent between the ages of 50 and 69. While its exact cause is unclear, genetic predisposition and autoimmunity are significant factors. Environmental triggers such as trauma, infections, sunburn, medications, and stress can provoke psoriasis.
Clinical Presentation Psoriasis primarily affects the skin and nails but can also impact joints and internal organs such as the eyes, heart, kidneys, and lungs. Common manifestations include:
Types of Psoriasis
Diagnosis Diagnosis typically involves a physical examination, blood tests, and a skin biopsy. The Psoriasis Area and Severity Index (PASI) may be used to assess severity.
Treatment Treatment aims to manage symptoms through:
Precautions and Considerations
Impact on Quality of Life Psoriasis can significantly impact physical and emotional well-being, leading to social exclusion and stigma due to misconceptions about the disease's contagiousness.
Risk Factors and Triggers
Prevention and Management
Complications of Psoriasis can lead to other health issues, including psoriatic arthritis, obesity, hypertension, type 2 diabetes, heart diseases, metabolic syndrome, inflammatory bowel disease, and eye problems.
Specialist Consultation For accurate diagnosis and treatment, consult a dermatologist or an immunologist.
It is advisable not to take or limit alcohol as a precautionary measure.
Tapirof 1% Cream should not be taken until prescribed. Your doctor will weigh the benefits and potential risks before prescribing it. Please consult your doctor.
It is not known if Tapirof 1% Cream passes into the breast milk. Please consult your doctor before taking Tapirof 1% Cream if you are breastfeeding. If you need to apply the cream or ointment on your breasts, don't do this shortly before giving a feed.
There have been no studies to investigate the effect of Tapirof 1% Cream on driving performance or the ability to operate machinery.
Let your doctor know if you have any history of kidney diseases before taking Tapirof 1% Cream. Your doctor will weigh the benefits and potential risks before prescribing Tapirof 1% Cream.
Let your doctor know if you have any history of liver diseases before taking Tapirof 1% Cream. Your doctor will weigh the benefits and potential risks before prescribing Tapirof 1% Cream.
Manage plaque psoriasis in affected individuals
Tapinarof is used in the treatment of psoriasis.
Tapinarof is a novel therapeutic agent classified as a therapeutic aryl hydrocarbon receptor-modulating agent (TAMA). Its effectiveness in treating psoriasis is attributed to its interaction with the aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor.
Mechanism of Action Upon binding to its ligand, AhR forms a heterodimer with the AhR nuclear translocator (ARNT). This complex then binds to DNA at specific recognition sites to regulate gene expression. AhR activation influences various transcription factors, including the nuclear factor κB (NF-κB) and nuclear factor erythroid 2-related factor 2 (Nrf2). Nrf2, a downstream product of AhR-induced transcription, possesses antioxidant properties that contribute to its therapeutic effects.
Role of AhR in Psoriasis Dysregulation of AhR is a hallmark of psoriasis. Patients with psoriasis exhibit higher serum concentrations of AhR. Activation of AhR in vitro has been shown to result in a gene expression profile implicated in the pathogenesis of psoriasis. Key effects of AhR activation include:
Tapinarof binds specifically to AhR and modulates a unique set of genes dysregulated in psoriasis, distinct from other AhR ligands. This specificity is crucial in its therapeutic role:
The anti-inflammatory effects of Tapinarof are potentially due to its dual action on AhR and Nrf2. Not all AhR agonists activate the Nrf2 pathway; for example, 2,3,7,8-tetrachlorodibenzo-p-dioxin does not exhibit antioxidant activity post-AhR activation. The unique ability of Tapinarof to engage both AhR and Nrf2 pathways is hypothesized.
Before taking Tapinarof, let your doctor know if you have any fungal, viral, or protozoa infections, liver, kidney diseases, hypercalcemia (high calcium levels in the blood), or hypervitaminosis D (excess Vitamin D levels in the blood).
Hypersensitive to any of its components.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.
Store in a cool and dry place away from sunlight
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information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.