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Clopixol Depot Injection 200mg/ml
Clopixol Depot is used for the management of schizophrenia symptoms. It is intended for initial treatment of acute psychotic episodes or exacerbation of psychosis related to schizophrenia.
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✅ Description:
Zuclopenthixol belongs to the group of medicines called neuroleptic agents. It is indicated for the management of schizophrenia and other psychotic illnesses. Schizophrenia is a serious mental disorder characterized by extremely disordered thinking, hallucinations, delusions, and abnormal behavior that affects your daily functioning.
Zuclopenthixol acts on nerve pathways in specific areas of the brain and restores the balance of certain chemical substances (neurotransmitters) in the brain that cause the symptoms of schizophrenia and other mental illnesses. Avoid smoking and consumption of alcohol while taking this medicine as it may increase the side effects such as drowsiness and dizziness.
Take Zuclopenthixol continuously at regular intervals even if you feel completely well, because the underlying illness may persist for a long time. The most common side effects of taking this medicine are injection site reactions, irregular heartbeat, dizziness, mental problems, and muscle pain. They are usually temporary and disappear with time.
Before taking Zuclopenthixol, inform your doctor if you have any lung, liver, kidney, or heart problems. If you are pregnant, or think you may be pregnant or breastfeeding, inform your doctor before taking this medicine as a precaution. Zuclopenthixol is strictly not recommended for use in children and adolescents under 18 years of age. Consult your doctor before taking it.
Safety Advices
Alcohol
UNSAFE
Use caution while driving or doing tasks requiring concentration as Clopixol Depot can cause dizziness and sleepiness.
Pregnancy
CONSULT YOUR DOCTOR
Clopixol Depot Injection is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
Breastfeeding
CONSULT YOUR DOCTOR
Clopixol Depot Injection is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
UNSAFE
Do not drive or operate any machines because this medicine may cause dizziness, drowsiness, or blurred vision.
Kidney
CONSULT YOUR DOCTOR
Clopixol Depot Injection should be taken with caution in patients with kidney problems. Consult your doctor for advice.
Liver
CONSULT YOUR DOCTOR
Clopixol Depot Injection should be taken with caution in patients with liver problems. Consult your doctor for advice.
✔️ Uses of Clopixol Depot Injection
- Schizophrenia
- Anxiety
✔️ How does Clopixol Depot Injection work?
Zuclopenthixol is a typical antipsychotic medicine that works by restoring the balance of certain chemical substances (neurotransmitters) in the brain. It exerts its actions by antagonizing the effects of dopamine by blocking the D1 and D2 dopamine receptors which improves the symptoms of schizophrenia, making it easier to function in everyday life.
✔️ Side Effects of Clopixol Depot Injection
- Drowsiness, blurred vision, tachycardia, nausea, dizziness, headache, excitement, postural hypotension, hyperprolactinemia, sexual dysfunction, ECG changes, hyperthermia, extrapyramidal symptoms, urinary frequency or incontinence, tardive dyskinesia.
- Potentially fatal: Neuroleptic malignant syndrome, blood dyscrasias.
✔️ Quick Suggestions:
- Monitor for signs of swelling and difficulty breathing.
- Maintain a balanced diet and exercise regularly.
- Monitor weight, blood sugar, and cholesterol levels.
- Avoid abrupt discontinuation without consulting your doctor.
✔️ Indications:
Clopixol Depot is a prescription medication used to treat schizophrenia and anxiety disorders. It helps alter thoughts and elevate mood, improving the patient's ability to think, feel, and behave.
✔️ Pharmacology
Zuclopenthixol, a thioxanthene derivative, binds strongly to dopamine D1 and D2 receptors. It also has a high affinity for α1-adrenergic and 5-HT2 receptors, with weaker activity at histamine H1 receptors, and an even lower affinity for muscarinic cholinergic and α2-adrenergic receptors.
✔️ Dosage & Administration of Clopixol Depot
Zuclopenthixol Depot: Requires close supervision after initiation to avoid over-medication or insufficient symptom control. Oral antipsychotics may be needed initially. The maintenance dose is typically 150-300 mg IM every 2-4 weeks, adjusted as needed.
Renal Dose:
- Dose reduction may be needed for renal impairment.
The injection is given into the muscle of the buttock or thigh. Can be taken with or without food.
✔️ Clopixol Depot may interact with:
- Tricyclic antidepressants
- Guanethidine and similar blood pressure medications
- Barbiturates and similar medications
- Levodopa and Parkinson’s medications
- Metoclopramide (gastrointestinal disorders)
- Other antipsychotics (e.g., thioridazine)
- Heartbeat-altering medications (e.g., quinidine, amiodarone, sotalol, erythromycin, moxifloxacin, lithium)
✔️ Contraindications
- Acute intoxication from alcohol, barbiturates, or opiates
- CNS depression, comatose states, suspected or confirmed subcortical brain damage, or circulatory collapse
- Known hypersensitivity to thioxanthenes, zuclopenthixol, or any component in the formulation
✔️ Pregnancy & Lactation
- The safety of zuclopenthixol during pregnancy has not been established.
- Zuclopenthixol is excreted in human milk; its safety during lactation is not established.
✔️ Precautions & Warnings
Use caution if you:
- Have used Clopixol Depot or other schizophrenia treatments before and had issues
- Are taking other medications
- Are pregnant, planning to become pregnant, or breastfeeding
- Consume alcohol regularly
- Have liver problems, Parkinson’s disease, seizures, dementia, glaucoma, kidney problems, risk factors for stroke, hypokalemia, hypomagnesemia, cardiovascular history, family history of blood clots, or are being treated for cancer
- Are using other antipsychotic medications
✔️ Storage Conditions:
Store in a cool, dry place, protected from light.
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