Rabix IG

Uses of Rabix IG

• Prevention of Rabies

How does Rabix IG work?

Human Rabies Immunoglobulin is generally given with vaccines. Human Rabies Immunoglobulin contains chemicals that protect the patient against infections.

Side Effects of Rabix IG

• Immediate: Hypotension, dyspnea, urticaria.
• Delayed: Inflammation, fever, pruritis, rash, adenopathy, arthralgia.

Quick Suggestions:

• Rabix IG protects you against rabies after you have been bitten, scratched, or injured by a suspected animal with rabies.
• It is given with the first dose of rabies vaccine, or not more than 7 days after the scratch or injury.
• It is given by injection around the wound and into the muscle at the side of the thigh (intramuscular).
• Protects you against rabies after you have been bitten, scratched, or received any injury from a suspected animal with rabies.
• Given with the first dose of rabies vaccine, or not more than 7 days after the scratch or injury.
• Given by injection around the wound and into the muscle at the side of the thigh (intramuscular).

Indication of Rabix IG

• For prevention of rabies in individuals exposed to the virus, particularly in severe cases such as:
  • Multiple percutaneous bites or scratches
  • Contaminated mucous membranes with saliva
  • Severe bites on the face, head, neck, and hands
  • Unexamined or suspected rabid animals
  • Bites in young children
• Provides passive immunity and must be used with a rabies vaccine.

Pharmacology

• Offers passive protection against rabies.
• Two types: Human Rabies Immunoglobulin (HRIG) and Equine Rabies Immunoglobulin (ERIG).
• HRIG is preferred due to its derivation from hyperimmunized human plasma.

Dosage & Administration of Rabix IG

• First-Aid Treatment: Immediate and thorough washing of bite wounds with soap and water.
• Dosage: 40 IU/kg body weight for both adults and children.
  • Infiltrate as much as possible around and into the wound.
  • Remainder administered intramuscularly (gluteal region).
• Children: May require dilution with sodium chloride for adequate infiltration.
• Combined Treatment: Administer rabies vaccine and immunoglobulin at different body sites. Rabies Immunoglobulin can be given up to 7-8 days after the first vaccine dose if not initially available.
• WHO Recommendations:
  • Touching or feeding animals, licks on intact skin: No treatment if history is reliable.
  • Minor scratches, superficial bites, and licks on broken skin: Administer vaccine on Days 0, 3, 7, 14, and 28.
  • Severe bites or mucous membrane contamination: Administer vaccine on Days 0, 3, 7, 14, and 28 (or Day 90 optional) and Rabies Immunoglobulin immediately.

Interaction

Allergic reactions to equine proteins may occur, but rabies risk outweighs contraindications.

Contraindications

Hypersensitivity to quetiapine.

Pregnancy & Lactation

• Rabies vaccine and immunoglobulin should be administered at different anatomical sites.
• Avoid corticosteroids as they suppress the immune response.

Precautions & Warnings

• Do not administer intravenously due to shock risk.
• Avoid repeated doses of rabies immunoglobulin after vaccination has started.
• Ensure the needle does not pierce a blood vessel.
• Shake well before use, but avoid vigorous shaking.

Storage Conditions:

• Store at +2°C to +8°C.
• Protect from light.
• Do not freeze.
• Keep out of reach of children.