Varilrix Vaccine 0.5ml

Uses of Varilrix Vaccine 0.5ml

• Prevention of Chickenpox

How does Varilrix Vaccine 0.5ml work?

Varilrix Vaccine is a vaccine. It helps develop immunity by initiating a mild infection. This type of infection does not cause illness but stimulates the body's immune system to produce antibodies to protect against any future infections.

Side Effects of Varilrix Vaccine 0.5ml

Common side effects include:

• Fever ≥102.0°F (38.9°C) in children: 14.7%
• Injection-site complaints in children: 19.3%
• Fever ≥100.0°F (37.8°C) in adolescents and adults: 10.2%
• Injection-site complaints in adolescents and adults: 24.4%
• Varicella-like rash at the injection site or generalized

Quick Suggestions:

• Varilrix Vaccine helps prevent chickenpox.
• It is given as an injection under the skin or into the muscle of the upper arm.
• It is given in two doses. The second dose is given 4 to 8 weeks after the first dose.
• You may get a rash or mild fever, or you feel tired or sore at the site of the injection.
• Do not take the Varilrix Vaccine if you are pregnant or have a weak immune system.

Pharmacology

The Varicella Virus Vaccine induces both cell-mediated and humoral immune responses to the varicella-zoster virus, though the exact contributions of these immune responses to protection from varicella are unknown.

Dosage & Administration

Each 0.5 mL dose is administered subcutaneously. For children (12 months to 12 years), the first dose is given at 12-15 months of age, with the second dose at 4-6 years of age. Adolescents (13 years and older) and adults receive two doses at a minimum interval of 4 weeks.

Interaction

Do not administer the vaccine to individuals with:

• Severe allergic reactions to any component of the vaccine (including neomycin and gelatin) or a previous dose of varicella-containing vaccine.
• Immunosuppression due to disease or medical therapy.
• Active febrile illness with a fever >38.5°C.
• Active, untreated tuberculosis.
• Pregnant women or those planning to become pregnant within the next 3 months.

Contraindications

Avoid using salicylates for 6 weeks after vaccination in children and adolescents due to the risk of Reye syndrome. Also, avoid close contact with high-risk individuals susceptible to varicella due to the potential transmission of the vaccine virus.

Pregnancy & Lactation

The vaccine is contraindicated during pregnancy due to the risk of congenital varicella syndrome. It is unknown if the vaccine virus is excreted in human milk; therefore, the benefits of breastfeeding should be weighed against the mother's clinical need for the vaccine.

Reconstitution

Use the supplied sterile diluent for reconstitution. After reconstitution, inspect for particulate matter and discoloration. Use the vaccine immediately after reconstitution, and discard if not used within 30 minutes. Do not freeze the reconstituted vaccine.

Precautions & Warnings

• Evaluate for immune competence in individuals with a family history of congenital or hereditary immunodeficiency.
• Avoid using immune globulins and other blood products concurrently with the vaccine.
• Avoid salicylates for 6 weeks following administration in children and adolescents.

Storage Conditions:

Store the vaccine between 2-8°C, protected from light. Do not freeze. Keep out of the reach of children.