Allphen 5mg/5ml Oral Solution

✔️ Uses of Allphen 5mg/5ml Oral Solution

Allergic conditions, Nausea and vomiting, Motion sickness, Insomnia

✔️ How does Allphen 5mg/5ml Oral Solution work?

• Allphen is an antiallergic medication.
• Blocks the action of histamine, relieving symptoms of allergy.
• Works on various areas of the brain to prevent nausea/vomiting and induce relaxation.

✔️ Side Effects of Allphen 5mg/5ml Oral Solution

• Nervous system disorders: Neuroleptic Malignant Syndrome, somnolence, dizziness, headaches, extrapyramidal effects including muscle spasm, tic-like movements of the head and face.
• Immune System Disorders: Allergic reactions, including urticaria, rash, pruritus, and anaphylaxis.
• Skin and Subcutaneous Tissue Disorders: Photosensitivity reaction.
• Metabolism and Nutrition Disorders: Anorexia.
• Gastrointestinal Disorders: Epigastric discomfort, dry mouth.
• Eye Disorders: Blurred vision.
• Blood and Lymphatic System Disorders: Blood dyscrasias including hemolytic anemia, and agranulocytosis.
• Renal and Urinary Disorders: Urinary retention.
• Psychiatric Disorders: Infants, newborns, and premature are susceptible to the anticholinergic effects of promethazine, while other children may display paradoxical hyperexcitability, restlessness, nightmares, and disorientation.
• Cardiac Disorders: Palpitations, arrhythmias.
• Vascular Disorders: Hypotension.
• Hepatobiliary Disorders: Jaundice.
• General Disorders and Administration Site Conditions: Tiredness.

✔️ Quick Suggestions:

• Allphen helps treat nausea, vomiting, and insomnia.
• Caution while driving; can cause dizziness and sleepiness.
• Avoid alcohol consumption.
• Use sunscreen or protective clothing to prevent increased skin sensitivity to sunlight.
• Do not take for more than 7 days.
• Stop at least three days before an allergy test.

✔️ Pharmacology

• Promethazine is a phenothiazine derivative that blocks postsynaptic mesolimbic dopaminergic receptors in the brain.
• Exhibits a strong α-adrenergic blocking effect and depresses the release of hypothalamic and hypophyseal hormones.
• Competes with histamine for the H1-receptor; muscarinic blocking effect may be responsible for antiemetic activity.
• Reduces stimuli to the brainstem reticular system.
• Well absorbed from the gastrointestinal tract.
• Clinical effects are apparent within 20 minutes after oral administration and generally last four to six hours, although they may persist as long as 12 hours.

✔️ Dosage & Administration of Allphen 5mg/5ml Oral Solution

• Adults: Initial dose one 25 mg tablet at night; may be increased to two or three 25 mg tablets at night if necessary.
• In allergic conditions more frequent administration, twice or three times daily, may be necessary, starting with one or two 10 mg tablets and increasing as required.
• Elderly: No specific dosage recommendations.
• Children: They may be treated more conveniently by the elixir containing 5 mg/5 ml.
• As an antihistamine in allergy: Children of 2-5 years: 5-15 mg, Children of 5-10 years: 10-25 mg.
• In cases where two doses in 24 hours are required, the lower dose stated should be given.
• As a sedative: Children of 2-5 years: 15-20 mg, Children of 5-10 years: 20-25 mg, Given as a single night-time dose.

✔️ Interaction

• Allphen 5 mg/5 ml may enhance the action of any anticholinergic agent, tricyclic antidepressant, sedative, or hypnotic.
• Alcohol should be avoided during drug treatment.
• Phenergan may interfere with immunologic urine pregnancy tests to produce false-positive or false-negative results.
• Phenergan should be discontinued at least 72 hours before the start of skin tests using allergen extracts.

✔️ Contraindications:

• Promethazine is contraindicated for use in children less than two years of age.
• Hypersensitivity to promethazine or any of the excipients.
• Phenergan should not be used in patients who are in a coma or suffering from CNS depression of any cause.
• It must not be given to neonates or premature infants.
• Phenergan should be avoided in patients who have been taking monoamine oxidase inhibitors within the previous 14 days.

✔️ Pregnancy & Lactation

• There is epidemiological evidence for the safety of promethazine in pregnancy.
• Animal studies have shown no hazard; nevertheless, it should not be used in pregnancy unless the physician considers it essential.
• The use of Phenergan is not recommended in the two weeks before delivery due to the risk of irritability and excitement in the neonate.
• Available evidence suggests that the amount excreted in milk is insignificant.
• However, there are risks of neonatal irritability and excitement.

✔️ Precaution & Warnings:

• The use of promethazine should be avoided in children and adolescents with signs and symptoms suggestive of Reye’s syndrome.
• Promethazine may thicken or dry lung secretions and impair expectoration.
• It should, therefore, be used with caution in patients with asthma, bronchitis, or bronchiectasis.
• Use with care in patients with severe coronary artery disease.
• Use with care in patients with narrow-angle glaucoma.
• Use with care in patients with epilepsy.
• Use with care in patients with hepatic insufficiency.
• Use with care in patients with renal insufficiency.
• Caution should be exercised in patients with bladder neck obstruction.
• Caution should be exercised in patients with pyloric-duodenal obstruction.

✔️ Storage Conditions:

• Protect from light.
• Do not use later than the date of expiry.
• Keep all medicines out of the reach of children.
• To be dispensed only on the prescription of a registered physician.