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Home Personal Care Diabetes Medicines Mirogab 5mg Tablet 10pcs

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Mirogab 5mg Tablet 10pcs

Beacon Pharmaceuticals Ltd.

Generic: Mirogabalin Besylate

Type: Tablet

Pack Size: 10 Pcs

Tablet

৳200 ৳186

🛒 How to order this item?

Discount Price: ৳ 186

MRP: ৳ 200 7% Off

⪼ Save ৳: 14 in this Product

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✅ Description:

Neuropathic Pain (NeP) is a significant global health issue that causes considerable suffering and disability. It leads to substantial morbidity and adversely impacts the quality of life, particularly affecting sleep, mood, and overall functionality. The increasing prevalence of NeP necessitates the development of new treatments to better manage this condition and improve patient outcomes.

Mirogabalin Besylate (Tarlige)

Mirogabalin besylate (Tarlige) is a novel gabapentinoid therapy developed by Daiichi Sankyo. It has been approved in Japan for the treatment of postherpetic neuralgia (PHN) and painful diabetic peripheral neuropathy (DPNP).

Mechanism of Action

Mirogabalin works by modulating pain through its interaction with the α2δ-1 subunit of voltage-gated calcium channels (VGCCs) on the dorsal root ganglion. This interaction results in:

High Affinity and Prolonged Dissociation Rate: Mirogabalin has a unique high affinity for the α2δ-1 subunit and a prolonged dissociation rate, leading to more sustained analgesia compared to traditional gabapentinoids.
Rapid Dissociation from α2δ-2 Subunit: This characteristic potentially reduces the incidence of central nervous system-specific adverse events (AEs), contributing to a superior safety profile.

Efficacy

Mirogabalin’s potent pain-modulating effect is attributed to its high affinity and prolonged action on VGCCs, providing sustained relief from neuropathic pain.

Adverse Events (AEs)

The most common adverse events associated with mirogabalin include:

Dizziness: Approximately 8-16%
Somnolence: Approximately 6-24%
Headache: Approximately 6-14%

Other less common AEs include constipation, nausea, diarrhea, vomiting, edema, fatigue, and weight gain. These AEs are relatively lower in incidence compared to those seen with traditional gabapentinoids.

Postmarketing studies are necessary to further evaluate mirogabalin’s:

Analgesic Durability: Long-term effectiveness in managing neuropathic pain.
Efficacy in Combination Therapy: Effectiveness when used alongside other antineuropathic agents such as tricyclic antidepressants, duloxetine, and tramadol/tapentadol.

Mirogabalin besylate represents a promising advancement in the treatment of neuropathic pain, offering sustained analgesia with a potentially better safety profile. Continued research and postmarketing studies will help solidify its place in neuropathic pain management, providing clinicians with an effective option for improving patient quality of life.

Safety Advices

Alcohol

UNSAFE

Pregnancy

SAFE IF PRESCRIBED

Breastfeeding

SAFE

Driving

CAUTION

Kidney

CONSULT YOUR DOCTOR

Liver

CAUTION

Mirogabalin Besylate

✔️ Uses of Mirogab 5mg Tablet

Neuropathic Pain
Diabetic peripheral neuropathic pain (DPNP)
Postherpetic neuralgia (PHN)
Peripheral neuropathic pain (PNP)

✔️ Side Effects of Mirogab 5mg Tablet

Dizziness
sleepiness/drowsiness
Dry mouth
Fluid overload with swelling
Blurred vision
Weight gain

✔️ Quick Suggestions:

✔️ Indication of Mirogab 5mg Tablet

✔️ Pharmacology

✔️ Dosage & Administration of Mirogab 5mg Tablet

✔️ Interaction

✔️ Contraindications

✔️ Pregnancy & Lactation

✔️ Precautions & Warnings

✔️ Storage Conditions:

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Check our pricing section for Mirogab 5mg Tablet 10pcs price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

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