Generic Name: Hydrocortisone 1% + Miconazole Nitrate 2%
Manufacturer/Distributor: Nipa Pharmaceuticals Ltd.
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Indications
For the topical treatment of inflamed dermatoses, where infections by sensitive organisms and inflammations coexist and. Intertrigo and infected eczema. For eczema or damp or dry dermatitis, including the annoying primary eczema or allergic eczema or allergic eczema, including it associated with acne. Also for interrupt eczema, including inflammatory sex, permitting, and genital dermatitis. Miconazole-sensitive organisms are dermatophytes and pathogenic yeasts (for example, Candida spp.): Many staple bacteria, including many Streptococcus and Staphylococcus strains.
Pharmacology
Miconazole is a substituted imidazole, is one of the families of azoles useful in the treatment of surface candidiasis and the dermatophytosis of skin and pity infections Versicolor, seborrhoeic acting. Also assets against Aspergillus spp., Cryptococcus neo formats, Pseudallicia Boydii, and some basic bacteria, including staphylococci and streptococci.
Hydrocortisone is a natural glucocorticoid that has now been prepared synthetically. Its function is important in the lesion of the skin, such as inflammation. It also has antimritical, anti-micro, and vasoconstrictive activity.
Miconazole is an imidazole antifungal agent that interferes with the synthesis of ergosterol and therefore modifies the permeability of the cell membrane of sensitive fungi. It thus causes fungal kill when applied to the skin, the hydrocortisone is absorbed by skin cells. Prevents the release of certain chemicals responsible for inflammation. Thus, hydrocortisone reduces inflammation.
Dosage & Administration
Apply to the affected area as a thin film two or four times daily for 1 to 2 weeks. Rub it well with your finger until this cream fully vanished on the skin. Treatment should be continued at least one week after the disappearance of all signs and symptoms. The same dosage applies to both adults and children.
Interaction
Amphotericin antagonizes the activity of Miconazole.
Contraindications
It is contraindicated in individuals who are hypersensitive to it or any of its components. Should not be used in pregnant mothers and lactating mothers without a physician's advice.
Side Effects
Rarely local sensitivity may occur. Long-term use may decrease in the production of natural hormones by the adrenal gland.
Pregnancy & Lactation
Administration of corticosteroids to pregnant animals at high doses can cause abnormalities in fetal development. Topical steroids should not be extensively used in pregnancy.
Precautions & Warnings
To be dispensed only on the prescription of a registered physician. Keep out of reach of children. Take care or consult with a physician in case of use in children and elderly people for long-term use.
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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