Generic Name: Permethrin 5% Topical
Manufacturer/Distributor: Square Pharmaceuticals Ltd.
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Indications
Use permethrin cream to treat infestations of scabies and crab lice (Pediculosis). The entire family can be affected by scabies. The entire family must be treated at once if just one member of the group contracts the infection.
Pharmacology
For the treatment of invasion with Sarcoptes Scabiei, Permethrin cream contains Permethrin, a pyrethroid that has the potential to act as a topical scabicidal agent (scabies). It affects the nerve cell film by interfering with the sodium channel current that regulates the polarization of the film. This disturbance causes the bugs' loss of motion and delayed repolarization.
Pharmacokinetics: The officially recommended organizational strategy is topical, and there is little information available on the systemic introduction or energy absorption following permethrin application to the skin.
Some systemic digestion occurs in the skin. During the first 48 hours, less than 0.5% of the connected permethrin is retained. The liver is most likely where absorbed permethrin is quickly metabolized by ester hydrolysis.
Administration & Dosage
Recommended duration of Treatment:
Interaction
Contraindications
Reapply to any area that will be washed throughout the 8-hour treatment period (such as after washing the hands). The doctor advised that if necessary, permethrin cream should be reapplied after 7 days.
Side Effect
In a small number of Scabies patients, discomfort on the skin, commonly described as burning, stinging, or tingling, develops soon after the cream is applied. Other temporary indications of irritation include erythema, edema, eczema, rash, and pruritus.
Pregnancy & Lactation
Pruritus, edema, and erythema are common symptoms of scabies infestation. Permethrin treatment may temporarily aggravate these symptoms. Patients should be advised to avoid contact with their eyes while applying the cream and to flush their eyes with water immediately if the cream gets into their eyes.
Precautions & Warnings
Storage Conditions
Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.
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