Sildenafil is indicated for the treatment of erectile dysfunction.
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Acmegra 100mg Tablet belongs to the phosphodiesterase type-5 (PDE 5) inhibitors group and is mainly used to treat adult men with erectile dysfunction (impotence). It can also be prescribed to treat pulmonary arterial hypertension, improving exercise capacity and slowing down clinical worsening.
By relaxing the blood vessels in the penis, Acmegra 100mg Tablet facilitates blood flow during sexual excitement, effectively treating erectile dysfunction. Furthermore, it dilates blood vessels, augmenting blood supply to the lungs, and eases the heart's workload, thereby addressing pulmonary hypertension.
Take Acmegra 100mg Tablet as prescribed by your doctor, considering your medical condition. Possible side effects like headache, nausea, dizziness, indigestion, and stomach upset may occur but often resolve gradually without medical intervention.
Avoid Acmegra 100mg Tablet if you're allergic to its components, nitrates, or riociguat. It's not recommended for children. Consult your doctor if you experience hearing or visual impairment. Refrain from alcohol consumption as it can hinder erection. If taken after a heavy meal, the medicine may take longer to work, so lighter meals are advised.
Drinking alcohol is known to cause erection impairment. You are advised not to drink alcohol in extreme amounts before taking Sildenafil.
Sildenafil is a medicine used to treat erectile dysfunction in males. Thus, it is not recommended to administer to pregnant women.
Sildenafil is a medicine used to treat erectile dysfunction in males. Thus, it is not recommended to administer to pregnant women.
Sildenafil can cause dizziness and can affect your vision. You should be careful if you need to drive.
Acmegra 100mg Tablet should be used with caution in patients with kidney diseases. Therefore, consult your doctor before taking it.
Acmegra 100mg Tablet is not recommended for use in patients having severe liver diseases. It should be used with caution in patients with other minor liver problems. Therefore, consult your doctor before taking it.
Acmegra 100mg Tablet works by blocking the effects of certain enzymes (PDE5) which limits blood flow to the penis. Therefore, it relaxes the blood vessels supplying the penis and improves blood flow and oxygen supply.
Sildenafil is a selective inhibitor of cyclic Guanosine Monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) used for the treatment of erectile dysfunction. It enhances the effect of nitric oxide (NO) by blocking phosphodiesterase type 5 (PDE5). PDE5 is responsible for the degradation of cGMP in the corpus cavernosum, leading to the relaxation of smooth muscles and increased blood flow to the corpus cavernosum. This mechanism contributes to the improvement of erectile function.
The recommended dosage of Sildenafil (such as in Acmegra 100mg Tablet) and instructions for its use are as follows:
When taking Acmegra 100mg Tablet:
In the case of overdose:
If you miss a dose:
Sildenafil interacts with other medicines and certain food items in the following ways:
Medicine Interactions:
Nitrates: Concurrent use of Sildenafil and medicines containing nitrates can result in dangerous hypotensive effects, leading to a significant drop in blood pressure. This combination should be avoided.
Alpha-Blockers: Co-administration of Sildenafil with alpha-blockers can cause a reduction in blood pressure. Caution is advised when using these medications together.
Amlodipine: Interaction between Sildenafil and Amlodipine may result in an increase in blood pressure. Monitoring is recommended if these medications are used concurrently.
CYP3A4 Inhibitors (e.g., Ritonavir): Sildenafil's exposure may increase when co-administered with CYP3A4 inhibitors like Ritonavir, commonly used in HIV treatment. This could lead to higher levels of Sildenafil in the body.
Food Interactions: Sildenafil can have significant interactions with certain food items:
Grapefruit and its Juice: Consuming grapefruit or its juice in combination with Sildenafil can lead to potentially dangerous effects, as it may interfere with the metabolism of the medication in the body.
Pomelo and its Juice: Similar to grapefruit, consuming pomelo or its juice alongside Sildenafil can also lead to adverse effects due to potential interactions.
Sildenafil should not be used under the following circumstances:
Regular Smokers: Regular smokers are advised against using Sildenafil due to the risk of a severe eye side effect known as NAION (non-arteritic anterior ischemic optic neuropathy), which involves excessive blood loss in the optic nerve.
Cardiovascular Conditions: Individuals who have experienced heart attacks, low blood pressure, myocardial infarction (heart attack), stroke, and cardiac failure are also cautioned against using Sildenafil to avoid potentially serious effects on their cardiovascular system.
Penile Deformities: Sildenafil is not recommended for individuals with penile deformities.
Rare Inherited Eye Diseases: Individuals with rare inherited eye diseases such as retinitis pigmentosa should avoid using Sildenafil.
Hypersensitivity to Sildenafil or Nitrates: Those who have a known hypersensitivity to Sildenafil or who have received treatment with medications containing nitrates should not use Sildenafil.
Age Restriction: Sildenafil is not recommended for individuals under the age of 18.
Stomach Ulcer or Bleeding Problems: Individuals with a history of stomach ulcers or bleeding problems, such as hemophilia, should avoid using Sildenafil.
Acmegra 100mg Tablet is not recommended for use in women.
Store in a dry place, away from light and heat, out of reach of children.
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