Semaglutide:
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Semaglutide: GLP-1 receptor agonist (anti-diabetic agent)
Enhances glycemic control through insulin secretion, slowing gastric emptying, and reducing postprandial glucagon secretion.
Consuming alcohol increases the risk of lactic acidosis and low blood sugar levels.
Not recommended while breastfeeding; unknown if it passes into breast milk. Discuss concerns with the doctor.
Not recommended while breastfeeding; unknown if it passes into breast milk. Discuss concerns with the doctor.
Blood sugar fluctuations may affect driving ability. Do not drive if symptoms of low or high blood sugar appear.
Caution in kidney impairment; benefits vs. risks evaluation needed.
Limited information on liver use; consult the doctor for concerns.
Type 2 Diabetes Mellitus
Glucagon-like peptide-1 (GLP-1) agonists, which are classified as incretin mimetics, play a crucial role in glucose metabolism by affecting various aspects of pancreatic and gastrointestinal functions. Here's a breakdown of the actions of GLP-1:
Enhanced Glucose-Dependent Insulin Secretion:
Suppression of Glucagon Secretion:
Slowing Gastric Emptying:
In summary, the actions of GLP-1 agonists contribute to improved glycemic control in individuals with type 2 diabetes. By promoting glucose-dependent insulin secretion, suppressing inappropriate glucagon secretion, and slowing gastric emptying, these medications help maintain more stable blood glucose levels throughout the day. This makes GLP-1 agonists valuable therapeutic options for managing type 2 diabetes, especially when lifestyle modifications and other oral medications are not sufficient.
Dosage:
Hepatic Impairment:
Child Dose:
Renal Dose:
Renal Impairment:
Subcutaneous (SC) Administration:
Drug-Drug Interactions:
Drug-Food Interactions:
Drug-Disease Interactions:
Personal or Family History of MTC:
Multiple Endocrine Neoplasia Syndrome Type 2 (MEN 2):
Known Hypersensitivity to Semaglutide:
There is limited data on Semaglutide use in pregnant women. Semaglutide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There are no data on the presence of Semaglutide in human milk, the effects on the breastfed infant, or the effects on milk production. Discontinue Semaglutide in women at least 2 months before a planned pregnancy due to the long washout period for Semaglutide.
Do not freeze the Fitaro Injection. Do not use it if it has been frozen. Store your Fitaro Injection in the refrigerator at 2°C to 8°C (36°F to 46°F). After the first use of Fitaro Injection, the pen can be stored for 56 days in a refrigerator (2°C to 8°C).
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