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Tirza 2.5 AutoGuarded Prefilled Syringe
Therapeutic Class: Dual GIP and GLP-1 Receptor Agonist
Dosage Form: Prefilled Syringe for Subcutaneous Injection
Strengths Available: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg
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✅ Description:
Tirza is indicated as an adjunct to diet and exercise to enhance glycemic control in adults with type 2 diabetes mellitus.
Limitations of Use
Not studied in individuals with a history of pancreatitis.
Not approved for type 1 diabetes mellitus.
⚠️ Always take under the supervision of a registered physician.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Pharmacology
Tirzepatide is a synthetic 39-amino-acid peptide with a C20 fatty diacid moiety, enhancing its albumin binding and extending its half-life.
It selectively activates GIP and GLP-1 receptors, boosting insulin secretion (first and second phase) and reducing glucagon—both in a glucose-dependent manner.
✔️ Side Effects
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Decreased appetite
- Dyspepsia
- Abdominal pain
✔️ Administration Instructions
- Inject once weekly any time of the day, with or without meals.
- Injection sites: Abdomen, thigh, or upper arm—rotate sites with each dose.
- Do not mix with insulin. If used together, inject at separate sites (not adjacent).
- Inspect syringe for discoloration or particles before use.
- Do not freeze. Discard if frozen or dropped on a hard surface.
- Latex allergy warning: Needle cover contains dry natural rubber (latex derivative).
✔️ Dosage & Administration
Route: Subcutaneous injection
Start with 2.5 mg once weekly (initiation dose, not for glycemic control)
After 4 weeks, increase to 5 mg once weekly
Further titration: Increase in 2.5 mg increments every 4 weeks as needed
Maximum dose: 15 mg once weekly
Pediatrics (<18 years): Safety and efficacy not established.
Geriatric patients: No dosage adjustment based solely on age.
Renal or hepatic impairment: Monitor closely; consider dose adjustments based on tolerability.
Missed Dose:
- Administer within 96 hours (4 days).
- If >4 days have passed, skip the missed dose and resume the regular schedule.
- The weekly injection day may be changed, but maintain at least 72 hours between doses.
✔️ Interaction
- Insulin or insulin secretagogues (e.g., sulfonylureas): Risk of hypoglycemia—dose adjustment may be needed.
- Oral medications: Tirza delays gastric emptying, potentially affecting absorption of critical drugs (e.g., warfarin).
- Hormonal contraceptives (oral): Recommend switching to a non-oral or barrier method for 4 weeks after initiation and after any dose escalation.
- Non-oral contraceptives are not affected.
✔️ Contraindications
- Hypersensitivity to tirzepatide or any component of the formulation
- Personal or family history of medullary thyroid carcinoma (MTC)
- History of multiple endocrine neoplasia syndrome type 2 (MEN 2)
✔️ Use in Pregnancy & Lactation
- Use during pregnancy only if benefits outweigh risks—uncontrolled diabetes also poses fetal risks.
- During breastfeeding, weigh potential effects on the infant against maternal benefit.
- Consider alternative treatments if needed.
✔️ Precautions & Warnings
- Thyroid tumors (MTC): Counsel patients and monitor for symptoms (e.g., neck mass, dysphagia).
- Pancreatitis: Discontinue immediately if suspected.
- Hypoglycemia: May need to reduce insulin or sulfonylurea dose.
- Hypersensitivity: Discontinue and manage accordingly.
- Renal impairment: Monitor function if severe GI symptoms develop.
- Diabetic retinopathy: Monitor for progression.
- Gallbladder disease: Evaluate if cholelithiasis is suspected.
✔️ Storage Conditions
- Store in a refrigerator (2°C to 8°C)
- Do not freeze
- Protect from light
- Keep out of reach of children
- For use only with a registered physician's prescription
