Amaryl 4mg Tablet

✔️ Uses of Amaryl 4mg Tablet

• Type 2 Diabetes

✔️ How does Amaryl 4mg Tablet work?

Amaryl 4mg Tablet works by increasing the secretion of insulin from the pancreas and also regulates the release of glucose from the liver.

✔️ Side Effects of Amaryl 4mg Tablet

• Headache
• Dizziness
• Nausea
• Fever
• Confusion
• Edema (Swelling)
• Urticaria
• Rash
• Anorexia
• Heartburn
• Bone Marrow Suppression
• Thrombocytopenia

✔️ Quick Suggestions:

• Incorporate regular exercise and a balanced diet into your routine, along with any other prescribed diabetes medications.
• While using Glimepiride, be cautious when driving or operating machinery until you understand its effects on you.
• Hypoglycemia can occur when combining Glimepiride with other antidiabetic medicines, alcohol, or skipping meals.
• Carry sugary food or juice to manage hypoglycemic symptoms like cold sweats and tremors.
• Liver function checks may be needed, and report symptoms like abdominal pain, appetite loss, or jaundice. Keep track of your blood sugar levels during Glimepiride usage.

✔️ Indication

Amaryl 4mg Tablet is prescribed for individuals with type 2 diabetes to lower high blood sugar levels when accompanied by a balanced diet and exercise. It can be used alongside insulin or other oral antidiabetic medications. By enhancing insulin production and secretion from the pancreas beta cells, Amaryl 4mg Tablet effectively reduces post-meal blood sugar levels.

✔️ Pharmacology

Glimepiride stimulates the insulin release from pancreatic β-cells and reduces glucose output from the liver. It also increases insulin sensitivity at peripheral target sites.

✔️ Dosage & Administration of

For adult Type 2 diabetes mellitus patients, the initial dose of Glimepiride is 1-2 mg daily, which can be increased by 1-2 mg at 1-2 week intervals. The maintenance dose is 4 mg daily, with a maximum of 6 mg daily. Elderly patients start with 1 mg once daily. In severe hepatic impairment, it's contraindicated.

In renal impairment, a dose of 1 mg PO qDay is recommended; adjust based on fasting blood glucose levels. Avoid severe cases. Take Amaryl 4mg Tablet after meals, swallowing with water, and don't crush or chew it. Follow your doctor's instructions on dose and duration, and avoid stopping without the doctor's advice.

Overdosage:

In case of accidental overdose, symptoms of hypoglycemia (increased hunger, sweating, shakiness, confusion) may occur. Consume sugary food immediately. If symptoms persist, seek medical help.

Missed Dose:

If you miss a dose of Amaryl 4mg Tablet, take it when remembered. If it's close to the next dose, skip the missed one. Avoid doubling doses.

✔️ Interaction

Drug Interactions:

Before taking Amaryl 4mg Tablet, inform your doctor about any ongoing medications, including:

• Diabetes medications (e.g., insulin, metformin)
• Pain and inflammation relievers (e.g., aspirin, ibuprofen)
• Urinary infection treatments (e.g., amikacin, nitrofurantoin)
• Antibiotics (e.g., tetracyclines, clarithromycin)
• Antifungal medications (e.g., fluconazole, miconazole)
• Blood clot prevention drugs (e.g., warfarin)
• Muscle-building agents (e.g., nandrolone, oxymetholone)
• Hormone replacement therapies (e.g., testosterone)
• Anti-depressants (e.g., fluoxetine)
• Cholesterol-lowering drugs (e.g., fenofibrate)
• Blood pressure medications (e.g., lisinopril, atenolol)
• Medications for heart rhythm abnormalities (e.g., disopyramide)
• Gout treatments (e.g., allopurinol)
• Cancer treatments (e.g., cyclophosphamide)
• Asthma medications (e.g., salbutamol)
• Emergency medications (e.g., adrenaline)
• Medications for constipation (e.g., lactulose)
• Epilepsy treatments (e.g., phenytoin)
• Medications for mental illness (e.g., chlorpromazine)
• Corticosteroids (e.g., prednisolone)
• Thyroid medications (e.g., levothyroxine)
• Asthma medications (e.g., salbutamol)
• Adrenaline (used in emergencies)
• Medications for constipation (e.g., lactulose)
• Medications for epilepsy (e.g., phenytoin)
• Barbiturates (used for sleep)
• Medications to reduce eye pressure (e.g., acetazolamide)
• Glucagon and diazoxide (for low blood sugar)
• Cimetidine (used for stomach ulcers)

✔️ Contraindications

Avoid taking Amaryl 4mg Tablets if:

• You are allergic to Glimepiride, Sulfonylureas, Sulfonamides, or any other ingredient in the tablets.
• You have type 1 diabetes.
• You are experiencing symptoms like fatigue, nausea, frequent urination, and muscle stiffness (indicative of diabetic ketoacidosis).
• You have severe kidney or liver disease.

✔️ Pregnancy & Lactation

Avoid taking Glimepiride during pregnancy. If you are pregnant or planning to become pregnant, consult your doctor and consider shifting to Insulin therapy. For breastfeeding mothers, Glimepiride should not be taken, as it could harm the child. If using this medication, consider switching to alternative feeding methods.

✔️ Precautions & Warnings

• There's an increased risk of cardiovascular (CV) mortality associated with Amaryl 4mg Tablets. Caution is advised for elderly patients and those with hepatic or renal impairment. In cases of congestive heart failure (CHF) or hepatic cirrhosis, there's a potential for the syndrome of inappropriate secretion of antidiuretic hormone (SIADH).
• Regular monitoring of blood glucose concentration is important. Use during pregnancy and lactation requires careful consideration. The excretion of Amaryl 4mg tablets in breast milk is unknown, so it's recommended to avoid its use during lactation.
• It's important to follow these precautions and consult your doctor if you have any concerns about using Amaryl 4mg Tablet, especially if you fall into any of the mentioned risk categories.

✔️ Storage Conditions

Do not store at temperatures above 30°C. Keep out of the reach of youngsters and away from light.