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Dumeg 500mg Tablet
Imeglimin acts through a dual mechanism:
Amplification of glucose-stimulated insulin secretion (GSIS):
- Preserves pancreatic β-cell mass, enhancing insulin production.
- Supports glucose-stimulated ATP generation and increases NAD+ synthesis in β-cells.
Enhanced insulin action:
- Reduces hepatic glucose production and improves insulin signaling in the liver and skeletal muscle.
At the molecular level, Imeglimin addresses mitochondrial dysfunction—a critical factor in type 2 diabetes (T2D) pathogenesis. Its effects include:
- Rebalancing respiratory chain activity to reduce oxidative stress.
- Preventing mitochondrial permeability transition pore opening, reducing cell death.
Imeglimin's unique mechanism targets defective cellular energy metabolism, differentiating it from other major anti-diabetic classes like biguanides, sulfonylureas, and GLP-1 receptor agonists.
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✅ Description:
Imeglimin is indicated for the treatment of type 2 diabetes mellitus (T2D):
- Effective as monotherapy or in combination with other diabetes therapies.
- Demonstrated safety and promising efficacy in clinical studies.
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✔️ Side Effects
Common side effects:
- Gastrointestinal: Nausea, diarrhea, constipation.
- Hypoglycemia: May cause symptoms like weakness, hunger, or sweating.
✔️ Dosage & Administration
- 1Adults: 1,000 mg (2 tablets) twice daily (morning and evening)
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush, or break it. Dumeg 500 tablets may be taken with or without food, but it is better to take them at a fixed time.
- Missed dose: Take as soon as remembered unless it is near the next dose; do not double doses.
- Overdose: Seek immediate medical attention. Supportive measures include gastrointestinal decontamination and clinical monitoring.
✔️ Imeglimin is contraindicated in patients with:
- Hypersensitivity to the drug or its components.
- Severe ketosis, diabetic coma, or pre-coma.
- Type 1 diabetes (for immediate hyperglycemia management with infusion/insulin).
✔️ Managing Blood Sugar While on Antidiabetic Medication
Hypoglycemia (Low Blood Sugar):
- Can occur when combined with other antidiabetic medicines, alcohol, or by delaying/skipping meals.
- Regularly check your blood sugar levels. If you experience symptoms of low blood sugar (e.g., dizziness, sweating, weakness), consume a snack or sugar source immediately.
Hyperglycemia (High Blood Sugar):
- Symptoms: Unusual thirst, frequent urination, and fatigue.
- Notify your doctor if these symptoms arise; your dosage may need to be adjusted.
Keep track of your blood sugar levels consistently while on this medication to avoid fluctuations.
Report any signs of rapid or deep breathing, muscle pain, fatigue, or drowsiness to your doctor immediately as these may indicate complications.
Lifestyle Modifications for Better Control:
- Follow a low-sugar diet.
- Engage in regular exercise to improve insulin sensitivity.
- Lose weight if advised by your doctor.
- Avoid smoking and reduce alcohol consumption to improve the medication's effectiveness.
✔️ Pregnancy & Lactation
- Pregnancy: Use only if the potential benefit outweighs the risks. Safety during pregnancy is not well-established.
- Lactation: Breastfeeding is not recommended as the drug may transfer into breast milk (based on animal studies).
✔️ Overdose Management
- Remove unabsorbed material from the gastrointestinal tract.
- Monitor clinical parameters, including ECG, and provide supportive therapy as needed.
✔️ Precautions & Warnings
- Hypoglycemia: Monitor while driving or operating machinery. Take sugar if symptoms occur; use glucose if on an alpha-glucosidase inhibitor.
- Renal Impairment: Dose adjustment may be required in patients with eGFR <15 ml/min/1.73 m².
- Combination therapy: Close monitoring is advised when used with other antidiabetic agents.
✔️ Storage Conditions
- Store below 30°C in a dry place, protected from light.
- Keep out of reach of children.
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