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Empadus M (12.5mg/500mg) Tablet 1 Strip
Empadus M 12.5+500 used as a treatment for adults with type 2 diabetes mellitus.
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✅ Description:
Empadus M is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when dual therapy with empagliflozin and metformin is appropriate. It is also indicated for reducing the risk of cardiovascular death in adults with type 2 diabetes and established cardiovascular disease.
This fixed-dose combination contains:
- Empagliflozin, a selective SGLT2 inhibitor that reduces renal glucose reabsorption and increases urinary glucose excretion.
- Metformin, a biguanide that reduces hepatic glucose production and enhances peripheral insulin sensitivity.
Together, they synergistically lower blood glucose levels and improve insulin action.
If a dose is missed, take it as soon as remembered. If it’s close to the next dose, skip the missed dose. Do not double the dose.
Caution is advised in:
- Elderly patients
- Patients at risk of dehydration
- History of genital infections
- Those undergoing surgery or radiologic procedures involving iodinated contrast agents
- Renal and hepatic function should be assessed before and during treatment
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration of Empadus M
- Initial Dose: Typically starts with empagliflozin 5 mg + metformin 500 mg once daily with meals.
- Maintenance Dose: May be gradually increased based on clinical response and tolerability to a maximum of empagliflozin 25 mg and metformin 2000 mg per day in divided doses.
- Pediatrics: Safety and efficacy not established in patients under 18 years.
- Pregnancy: Not recommended during pregnancy due to potential fetal risk.
- Lactation: Both components are excreted in breast milk. Use only if clearly necessary.
Administration: Should be taken with food to minimize gastrointestinal side effects.
✔️ Adverse Effects of Empadus M
- Gastrointestinal upset (nausea, vomiting, diarrhea, abdominal pain)
- Headache, dizziness, fatigue
- Polyuria, increased thirst, dry mouth
- Weight loss
- Diabetic ketoacidosis (DKA)
- Lactic acidosis
- Hypoglycemia (especially with insulin/sulfonylureas)
- Urinary and genital tract infections (e.g., vaginal candidiasis, balanitis)
- Hypotension
- Dysuria, urticaria
✔️ Empadus M is contraindicated in:
- Type 1 diabetes or diabetic ketoacidosis (DKA)
- Severe renal impairment (eGFR < 30 mL/min/1.73 m²)
- Severe hepatic dysfunction
- Heart failure
- Active urinary tract infections
- Recent surgery or major trauma
- Known hypersensitivity to empagliflozin, metformin, or any component of the formulation
- History of lactic acidosis
✔️ Drug Interactions
- Increased risk of hypoglycemia with insulin, sulfonylureas, and meglitinides.
- May increase dehydration risk with diuretics.
- Risk of lactic acidosis with alcohol, contrast media, or nephrotoxic agents.
- Beta-blockers may mask symptoms of hypoglycemia.
- ACE inhibitors and ARBs may enhance the risk of hypotension.
- Steroids and thyroid hormones may reduce glycemic control.
✔️ Storage
Store below 30°C in a cool, dry place away from direct light and moisture. Keep out of the reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
