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Empadus M 5/1000 ER 1 Strip
Empadus M 5/1000ER Tablet, Empagliflozin 5 mg + Metformin HCl ER 1000 mg
A dual-action therapy for Type 2 Diabetes Mellitus. If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double the dose to make up for a missed one.
- Monitor renal function regularly
- Caution in elderly and volume-depleted patients
- Discontinue before surgery or radiologic studies with contrast
- Increased risk of genital infections, dehydration, DKA, and lactic acidosis
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✅ Description:
Empadus M 5/1000ER combines two complementary antidiabetic agents:
- Empagliflozin – an SGLT2 inhibitor that enhances urinary glucose excretion
- Metformin Hydrochloride (Extended Release) – a biguanide that reduces hepatic glucose production and improves insulin sensitivity
This combination is used in conjunction with diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus (T2DM). It may help reduce the risk of cardiovascular death in patients with established cardiovascular disease.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ How does Empadus M 5/1000 ER work?
Empagliflozin blocks the sodium-glucose co-transporter 2 (SGLT2) in the kidneys, reducing glucose reabsorption and increasing glucose excretion via urine.
Metformin ER suppresses hepatic glucose output and improves peripheral insulin sensitivity.
Together, they offer synergistic blood sugar control.
✔️ Dosage & Administration of Empadus M 5/1000 ER
- Recommended Dose: Start with Empagliflozin 5 mg + Metformin 1000 mg once daily with meals.
- Maximum Daily Dose: Empagliflozin 25 mg and Metformin 2000 mg
- Gradual dose titration is recommended to improve tolerability, particularly for metformin.
- Pregnancy: Not recommended, especially during the 2nd and 3rd trimesters
- Lactation: Empagliflozin and metformin are excreted in breast milk; may pose a risk to nursing infants
- Pediatrics: Safety and efficacy in patients <18 years have not been established
- Renal Impairment: Contraindicated in patients with eGFR < 30 mL/min/1.73 m²
Swallow whole with food. Do not crush or chew. Dosage should be individualized based on patient response and tolerability.
✔️ Contraindications
- Type 1 diabetes mellitus
- Diabetic ketoacidosis (DKA)
- Severe renal impairment (eGFR < 30 mL/min/1.73 m²)
- Severe hepatic impairment
- History of lactic acidosis
- Hypersensitivity to any component
- Conditions predispose
✔️ Drug Interactions
Use with caution alongside:
- Insulin or Sulfonylureas – increased risk of hypoglycemia
- Thiazolidinediones may increase the risk of fluid retention/heart failure
- ACE inhibitors / ARBs / Diuretics – risk of hypotension and dehydration
- Steroids / Thyroid Hormones – may affect glycemic control
- Beta-blockers may mask signs of hypoglycemia
✔️ Side Effects of Empadus M 5/1000 ER
- Nausea, vomiting, diarrhea
- Headache, dizziness
- Abdominal discomfort
- Fatigue
- Increased urination, dry mouth, and thirst
- Weight loss
- Serious adverse effects:
- Lactic acidosis
- Diabetic ketoacidosis (DKA)
- Severe hypoglycemia (especially when used with insulin/sulfonylureas)
- Urinary tract infections (UTIs), genital yeast infections
- Urticaria, dysuria, vaginal candidiasis
✔️ Storage:
Store below 30°C, protected from light and moisture
Keep out of reach of children
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
