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Gluretor 0.5mg 10pcs
Generic Name: Repaglinide 0.5 mg
Manufacturer/Distributor: Pacific Pharmaceuticals Ltd.
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✅ Description:
Indications
In patients with type 2 diabetes mellitus (NIDDM) whose hyperglycemia cannot be controlled adequately by diet and exercise alone, repaglinide is used as an addition to diet and exercise to lower blood glucose. It's also approved for use with Metformin to help individuals with hyperglycemia who can't control their blood sugar with exercise, diet, or either Repaglinide or Metformin alone.
Pharmacology
Repaglinide binds to specific receptors in the cell membrane, causing ATP-dependent K+ channels to close and the cell membrane to depolarize. This results in Ca++ inflow, increased intracellular Ca++, and insulin secretion stimulation.
Dosage & Administration
For patients not previously treated or whose HbA1c is <8%, the starting dose should be 0.5 mg before each meal.
For patients previously treated with blood glucose-lowering drugs and whose HbA1c is >8%, the initial dose is 1 or 2 mg before each meal.
Repaglinide should be taken immediately or up to 30 minutes before each meal.
Dosage should be adjusted according to response at intervals of 1-2 weeks; up to 4 mg may be given as a single dose, a maximum of 16 mg daily.
Contraindications
Diabetic ketoacidosis, with or without coma, is contraindicated in individuals using repaglinide.
Diabetes mellitus type 1 and a history of hypersensitivity to the medication or its inactive components.
Side Effects
Hypoglycemia and associated symptoms are the most common Repaglinide adverse effects. Upper respiratory infections, diarrhea, constipation, nausea, and vomiting are among the other symptoms. Rashes and urticaria are examples of hypersensitivity reactions.
Pregnancy & Lactation
There is no evidence of safety in pregnant women. Repaglinide should only be taken during pregnancy if it is absolutely necessary. Repaglinide is not known to be excreted in human milk. Because many medications are excreted in human milk and because Repaglinide can cause major adverse reactions in nursing infants, a choice should be made whether to stop breastfeeding or stop taking the drug, taking into account the drug's importance to the mother.
Precautions & Warnings
Affront ought to be substituted amid concurrent sickness (such as myocardial dead tissue, coma, disease, and injury) and amid surgery. All verbal blood glucose-lowering drugs are competent in creating hypoglycemia. Repaglinide ought to be managed with suppers to reduce the chance of hypoglycemia.
Storage Conditions
Do not store at temperatures above 30°C. Keep out of the reach of youngsters and away from light.
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