Informet 850mg Tablet 10pcs

Uses of Informet 850mg Tablet

• Type II diabetes mellitus

How does Informet 850mg Tablet work?

Informet 850 works by lowering glucose production in the liver, delaying the absorption of sugar (glucose) from the intestines, and increasing the body's sensitivity to insulin.

Side Effects of Informet 850mg Tablet

• Common: Nausea, vomiting, diarrhea, abdominal pain, taste disturbance
• Rare: Lactic acidosis, liver function issues, vitamin B12 deficiency, skin reactions

Quick Suggestions:

• You’ve been prescribed Metformin to manage your blood sugar and lower the risk of complications like heart attacks related to diabetes.
• It is less likely to cause weight gain or low blood sugar compared to other diabetes medications.
• While rare with Metformin alone, low blood sugar (hypoglycemia) can occur if combined with other antidiabetic drugs, alcohol, or missed meals. Always carry a quick sugar source (e.g., candy or glucose tablets) for immediate relief.
• If you experience rapid breathing, persistent nausea, vomiting, or stomach pain, inform your doctor immediately. These could be signs of lactic acidosis, a rare but serious side effect of Metformin.
• Long-term use may cause a deficiency in vitamin B12, leading to symptoms like fatigue, pale skin, shortness of breath, or headaches. Notify your doctor if these occur, as you may need supplements.
• Regular monitoring of your blood sugar and kidney function is important while on Metformin to ensure safe and effective treatment.

Informet 850 is used in adults and in children (aged 10 years or older) to manage:

• Type II diabetes mellitus

Pharmacology

Informet contains metformin, a biguanide that lowers blood glucose by decreasing liver glucose production, reducing intestinal glucose absorption, and increasing insulin sensitivity for better glucose uptake in peripheral tissues. Unlike sulfonylureas, it does not cause hypoglycemia.

Dosage & Administration of Informet 850mg Tablet

For immediate release:

• Adults: Start with 500 mg twice daily or 850 mg once daily with meals. Increase the dose in 500 mg increments weekly (or 850 mg every two weeks) up to 2000 mg daily. Maximum dose: 2550 mg daily in divided doses.
• Children (10+ years): Start with 500 mg twice daily, increase weekly up to a maximum of 2000 mg daily in divided doses.

For extended-release:

• Adults: Start with 500 mg once daily with the evening meal. Increase by 500 mg weekly up to 2000 mg once daily or 1000 mg twice daily.

Renal impairment:
Avoid if eGFR < 30 mL/min. Assess risks if eGFR is between 30-45 mL/min.

Hypoglycemia is rare but lactic acidosis may occur. In such cases, hospital treatment is needed with hemodialysis to remove lactate and metformin.

Take  Informet 850mg Tablet preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition. Do not stop taking  Informet 850mg Tablet unless your doctor advises you to stop.

Interaction

Metformin's absorption can be increased by Nifedipine. It can interact with cationic drugs like Amiloride and Digoxin, affecting kidney transport. Certain drugs like corticosteroids and oral contraceptives may reduce their blood sugar-lowering effect.

Contraindications

• Hypersensitivity to metformin or excipients
• Severe renal failure
• Acute conditions affecting renal function or tissue hypoxia
• Alcoholism

Pregnancy & Lactation

• Pregnancy: Insulin is preferred over Informet during pregnancy due to risks of uncontrolled diabetes.
• Breastfeeding: Not recommended as metformin passes into breast milk.

Precautions & Warnings

• Monitor renal function regularly, especially in the elderly.
• Informet can lower vitamin B12 levels and increase hypoglycemia risk when combined with insulin or insulin secretagogues.
• Stop Informet 2-3 days before surgery or clinical investigations and restart after confirming normal renal function.

Storage Conditions:

Store below 30°C, away from light and moisture, and out of reach of children.