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Linadus M XR 5/1000mg Tablet 1 Strip
Linadus-M XR 1000
Composition: Linagliptin + Metformin Hydrochloride (Extended Release)
Indication: Type 2 Diabetes Mellitus
- Always take with food.
- Continue diet and exercise as advised.
- Carry a sugar source in case of hypoglycemia.
- Inform healthcare providers before any surgery.
- Immediately report symptoms of lactic acidosis (rapid breathing, nausea, abdominal pain).
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✅ Description:
Linadus-M XR 1000 is a fixed-dose combination of linagliptin and metformin, used to improve glycemic control in adults with type 2 diabetes, particularly when dual therapy is appropriate. It helps prevent complications like nephropathy, retinopathy, and cardiovascular events.
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✔️ Composition
Linagliptin + Metformin Hydrochloride
✔️ Mechanism of Action
Metformin: Lowers glucose production in the liver, slows intestinal absorption of glucose, and enhances insulin sensitivity.
Linagliptin: A DPP-4 inhibitor that prolongs incretin activity, enhancing insulin secretion and decreasing glucagon levels in a glucose-dependent manner.
Together, they target both fasting and postprandial glucose levels for better blood sugar control.
✔️ Dosage & Administration
Adults (Extended-Release Tablets):
Individualized dosing based on current therapy and tolerability.
Maximum: Linagliptin 5 mg + Metformin 2000 mg per day.
It should be taken with meals to minimize gastrointestinal side effects.
Missed Dose: Take as soon as remembered. If it’s close to the next dose, skip the missed one. Do not double-dose.
✔️ Renal Dose Adjustment
eGFR <30 mL/min/1.73 m²: Contraindicated
eGFR 30–45: Do not initiate; reassess if already on therapy
Monitor renal function before starting and periodically thereafter.
✔️ Storage ConditionContraindications
- Known hypersensitivity to components
- Type 1 diabetes or diabetic ketoacidosis
- Severe renal or hepatic impairment
- Acute conditions that may affect kidney function (e.g., dehydration, sepsis)
- Excessive alcohol use
- Pregnancy and lactation (use only if clearly needed)
✔️ Side Effects
Very common (>10%): Hypoglycemia (with sulfonylureas)
Common (1–10%): Diarrhea, nasopharyngitis, headache, nausea
Others (Frequency not defined): Pancreatitis, allergic reactions, decreased appetite, vomiting, pruritus, cough
✔️ Drug Interactions
Linagliptin: Affected by CYP3A4 and P-gp modulators (e.g., ritonavir, rifampicin).
Metformin: Increased lactic acidosis risk with alcohol, iodinated contrast agents, and cationic drugs (e.g., cimetidine). Monitor renal function closely.
✔️ Precautions & Warnings
Monitor for signs of lactic acidosis, pancreatitis, or hypoglycemia.
- Temporarily discontinue before contrast imaging or surgery.
- Caution in the elderly, the renally impaired, or those with heart failure.
- In breastfeeding, metformin appears in breast milk; linagliptin data are lacking—assess risk-benefit.
✔️ Storage:
Keep in a cool & dry place (below 30°C), protected from light & moisture. Keep out of the reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
