Metglip DS | 500mg+5mg | Metformin + Glipizide | Tablet | ePharma
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Metglip DS (500mg+5mg) Tablet

Generic: Metformin + Glipizide

Type: Tablet

Pack Size: 10 Pcs

Metglip DS is used to treat Type 2 Diabetes Mellitus


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Discount Price: ৳ 46.5
MRP: ৳ 50 7% Off

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✅ Description:

  • Metformin + Glipizide  is a combination medication used in the treatment of type 2 diabetes mellitus, a metabolic disorder characterized by high blood sugar levels. This condition can occur due to insulin resistance, where the body's cells do not respond effectively to insulin, or due to inadequate insulin production by the pancreas.
  • This medication contains two active ingredients, Glipizide and Metformin, each with its unique mechanism of action:
  • Glipizide belongs to the class of sulfonylureas and helps in diabetes management by stimulating the pancreas to release more insulin and by reducing glucose production in the liver. It acts relatively quickly compared to other sulfonylureas.
  • Metformin is classified as a biguanide and primarily works by decreasing glucose production in the liver and improving the sensitivity of body tissues to insulin. It does not increase insulin secretion but enhances its effects, making it more efficient in controlling blood sugar levels. Metformin is particularly useful in obese patients.
  • To effectively manage diabetes with Metformin + Glipizide, it is essential to follow your doctor's prescribed dosage and take the medication with food at regular intervals to avoid stomach upset. Your doctor may adjust the dosage over time based on your blood sugar levels.
  • Common side effects associated with Metformin + Glipizide include hypoglycemia (low blood sugar), nausea, diarrhea, indigestion, headache, dizziness, blurred vision, weakness, cold sweats, stomach pain, weight gain, and edema (swelling). While not everyone experiences these side effects, it is crucial to seek medical attention if they occur.
  • It's important to note that Metformin + Glipizide can rarely lead to a serious condition called lactic acidosis, characterized by an excess of lactic acid in the blood. This risk is higher in individuals with kidney, liver, or heart diseases. Therefore, it is crucial to inform your doctor about any existing medical conditions or a history of anemia, seizures, heart, kidney, or liver issues before starting this medication.
  • Additionally, if you are on a restricted diet or have limitations on fluid intake, discuss this with your doctor as Metformin + Glipizide can potentially lead to dehydration, low blood sugar, and kidney problems. Do not start or stop this medication without your doctor's guidance. It should only be used as prescribed by a healthcare professional.

Safety Advices


Alcohol
UNSAFE

It is unsafe to consume alcohol while taking Metglip DS. Alcohol can lower blood sugar levels, leading to potential dangers. Additionally, alcohol can increase the risk of a serious condition called lactic acidosis.


Pregnancy
CONSULT YOUR DOCTOR

Metglip DS should not be used during pregnancy as it may harm the unborn baby. Insulin is generally preferred for managing diabetes during pregnancy. Always consult your doctor before taking any medication during pregnancy.


Breastfeeding
CONSULT YOUR DOCTOR

Avoid using Metglip DS while breastfeeding as there is limited information available about its safety for lactating women. Consult your doctor before using any medication while breastfeeding.


Driving
CAUTION

Metglip DS can cause low blood sugar levels (hypoglycemia), which may impair your ability to drive safely. It's important to keep sources of sugar, juice, or a chocolate bar in your car in case you experience hypoglycemic symptoms such as dizziness, drowsiness, visual disturbances, or sweating while driving. If these symptoms occur, stop driving immediately and consume sugar or juice. Do not use sugar-free products during such episodes.


Kidney
CONSULT YOUR DOCTOR

Let your doctor know if you have any history of kidney diseases when you are prescribed Metglip DS.


Liver
CONSULT YOUR DOCTOR

Let your doctor know if you have any history of liver diseases or hepatic impairment when you are prescribed Metglip DS.

Similar Products

✔️ Uses of Metglip DS

Type 2 Diabetes Mellitus

✔️ How does Metglip DS work?

Metglip DS works by the combined action of Glipizide and Metformin. Metformin works by decreasing the amount of glucose absorbed from the intestine, lowering the amount of sugar created by the liver, and facilitating the entry of sugar into the cells. Glipizide works by stimulating the release of insulin from your pancreas, thus reducing blood sugar.

✔️ Side Effects of Metglip DS

Common side effects of Glipizide and Metformin may include hypoglycemia, diarrhea, nausea/vomiting, abdominal pain, headache, and musculoskeletal pain.

✔️ Quick Suggestions:
  • Monitor Blood Sugar: Regularly monitor your blood sugar levels while taking this medication to ensure it is effectively controlling your diabetes.
  • Risk of Hypoglycemia: Be aware that Glipizide + Metformin can lower your blood sugar levels. This risk is increased when it is used in combination with other antidiabetic medications, alcohol consumption, or if you delay or miss a meal. Be cautious to avoid hypoglycemia.
  • Surgery Under General Anesthetic: If you are scheduled to have surgery under general anesthesia, inform your doctor about your diabetes treatment. They may need to adjust your medication regimen.
  • Lactic Acidosis: This medication may rarely cause a serious condition called lactic acidosis, characterized by symptoms such as deep or rapid breathing, persistent nausea, vomiting, and stomach pain. If you experience these symptoms, contact your doctor immediately.
  • Liver Function Monitoring: Your doctor may periodically check your liver function while you are taking Glipizide + Metformin. Inform your doctor if you develop symptoms like abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
✔️ Indications:

Glipizide & Metformin are prescribed to improve glycemic control in patients with type 2 diabetes who cannot effectively manage their hyperglycemia through diet and exercise alone. It is also used as a second-line therapy in individuals with type 2 diabetes when initial treatment with either a Sulfonylurea or Metformin, along with lifestyle modifications, does not achieve adequate glycemic control.

✔️ Pharmacology:

Metformin: This biguanide antihyperglycemic drug enhances glucose tolerance in type 2 diabetic patients by reducing both fasting and post-meal blood glucose levels. It improves insulin sensitivity by increasing peripheral glucose uptake and utilization, decreases glucose production in the liver, and reduces intestinal glucose absorption. Unlike sulfonylureas, Metformin does not cause hypoglycemia or excessive insulin secretion.

Glipizide: This sulfonylurea medication stimulates insulin production from the pancreas, primarily by enhancing the function of beta cells in the pancreatic islets. The mechanism of action of oral sulfonylureas may include extrapancreatic effects.

✔️ Dosage & Administration of Metglip DS

Glipizide & Metformin should be taken once or twice daily with meals and should be initiated at a low dose, followed by gradual dose escalation.

Initial Therapy: The recommended starting dose is 250 mg/2.5 mg once a day with a meal.

Second-Line Therapy: The recommended starting dose is 500 mg/2.5 mg or 500 mg/5 mg twice daily with morning and evening meals. The maximum daily dose recommended is 2000 mg Metformin/20 mg Glipizide.

✔️ Interaction
  • Cimetidine can reduce Metformin clearance in the kidneys.
  • Alcohol can amplify Metformin's antihyperglycemic and hyperlactatemic effects.
  • Certain medications, including nonsteroidal anti-inflammatory drugs, certain azoles, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta-adrenergic blocking agents, may potentiate the hypoglycemic action of sulfonylureas.
✔️ Contraindications
  • Hypersensitivity to the medication.
  • Renal impairment.
  • Diabetic coma and ketoacidosis.
  • Chronic renal disorders.
  • Congestive heart failure.
  • Trauma.
  • Dehydration.
  • Alcoholism.
  • Pregnancy and breastfeeding, among other contraindications.
✔️ Pregnancy & Lactation

The use of angiotensin-II receptor antagonists during pregnancy should be avoided unless absolutely necessary. These medications have been associated with issues related to blood pressure management, renal function in newborns, skull abnormalities, and oligohydramnios. There is limited information on the use of angiotensin-II receptor antagonists during breastfeeding, and they are not recommended while nursing.

✔️ Precautions & Warnings

Metformin is primarily eliminated through the kidneys, and the risk of Metformin accumulation and lactic acidosis increases as renal function declines. Patients with serum creatinine levels above the upper limit of normal should not receive Metformin. Metformin dosing should be carefully adjusted in elderly individuals with advanced age-related renal function decline. Metformin therapy should be temporarily discontinued before surgery and should not be resumed until the patient's oral intake is restored, and normal renal function is confirmed.

✔️ Storage Conditions

Store at temperatures not exceeding 30°C (86°F) and keep out of reach of children.

Frequently Asked Questions (FAQ)

Your doctor may recommend you take Metglip Ds Tab with or after having food.

Vomiting, diarrhoea, stomach pain, dizziness

Metglip DS should be taken as directed by your doctor. Swallow it as a whole with a glass of water, with or after your meals. Do not cut, break or chew the medicine.

The use of Metglip DS can lead to a rare but serious condition called lactic acidosis. Lactic acidosis is characterized by elevated levels of lactic acid in the blood, which can be life-threatening. This condition is more likely to occur in individuals with certain risk factors, such as: Kidney problems: Lactic acidosis is more common in people with impaired kidney function because the kidneys are responsible for removing metformin from the body. If your kidneys are not functioning properly, metformin can accumulate in your system, increasing the risk of lactic acidosis. Dehydration: Severe dehydration can contribute to lactic acidosis. It's important to stay well-hydrated, especially if you experience conditions that can lead to fluid loss, such as vomiting or diarrhea. Excessive alcohol consumption: Alcohol can affect the way your body metabolizes metformin, increasing the risk of lactic acidosis. It's advisable to limit or avoid alcohol while taking this medication. Certain medical conditions: Conditions such as severe infections, heart failure, or respiratory disorders can increase the risk of lactic acidosis. Symptoms of lactic acidosis can include muscle pain or weakness, dizziness, extreme tiredness, coldness or numbness in the arms or legs, difficulty breathing, nausea, vomiting, stomach pain, and slow heart rate. If you experience any of these symptoms while taking Glipizide+Metformin, it's crucial to stop taking the medication immediately and seek medical attention. Lactic acidosis is a medical emergency that requires prompt treatment.

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Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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