Neugalin XR 82.5mg is a medication used to relieve pain caused by nerve damage (neuropathic pain) due to conditions like diabetes, shingles, spinal cord injury, and others. It is also used to treat muscle pain and stiffness in fibromyalgia and certain types of seizures in combination with other medicines.
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Pregabalin, the active ingredient in Neugalin XR 82.5mg Capsule, is categorized as an anticonvulsant medication. Its primary applications include the prevention of neuropathic pain, treatment of epilepsy (seizure episodes), management of fibromyalgia (musculoskeletal pain), and relief from neuralgia (pain associated with damaged or irritated nerves). Neuropathic pain, a condition characterized by chronic nerve pain, can result from various diseases like diabetes, shingles, spinal cord injury, or injuries to tissues, muscles, or joints.
Pregabalin, containing Pregabalin, acts by calming damaged or overactive nerves in the body, addressing nerve-related pain and seizures. Additionally, it reduces the transmission of pain signals from damaged nerves.
Pregabalin consumption is unsafe, as it causes excessive drowsiness with alcohol.
Use of Pregabalin may increase the risk of drowsiness, dizziness, difficulty in concentrating, etc. Hence, avoid performing activities such as driving or operating machines if you experience any of these symptoms.
No specific information is available for this.
Neugalin XR 82.5 is believed to work by reducing abnormal electrical activity in the brain for epilepsy, interfering with pain signals for neuropathic pain, and stopping the release of certain chemical messengers for anxiety.
Common side effects include blurred vision, difficulty paying attention, dizziness, dry mouth, edema (swelling), sleepiness, and weight gain.
Pregabalin is utilized in the treatment of various conditions, including:
Pregabalin is a derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Unlike direct binding to GABAA, GABAB, or benzodiazepine receptors, it exhibits a high affinity for the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. With an oral bioavailability exceeding 90%, it is dose-independent. The drug is primarily eliminated through renal excretion in its unchanged form, featuring a half-life of approximately 6.3 hours in individuals with normal renal function.
Adult Dose:
Neuropathic pain, Postherpetic Neuralgia:
Diabetic Peripheral Neuropathic Pain:
Adjunct in partial seizures:
Fibromyalgia:
Child Dose: Safety and efficacy not established.
Renal Dose for Renal Impairment:
Hemodialysis:
CrCl (ml/min) Dosage Recommendation:
Take Neugalin XR 82.5 as prescribed by your doctor, with or without food. It's important to take it at the same time each day. The initial dose is usually low and may be increased gradually. Missing a dose should be avoided, but if you forget, take it as soon as possible
Lorazepam:
Report the use of Lorazepam or any other medicine that you take for sleep disorders or anxiety problems. The risk of adverse effects like dizziness, drowsiness, confusion, lack of focus, etc., is very high while taking these medicines together. Special precaution is advised if these medicines are taken by an elderly person.
Pioglitazone:
Report the use of Pregabalin to the doctor before receiving Pioglitazone or any other medicine used for controlling high blood sugar levels. These medicines could increase the risk of weight gain, fluid retention, and heart failure when taken together. You may need a dose adjustment and frequent monitoring to safely use these medicines together.
Ramipril:
Report the use of Ramipril or any other medicine belonging to the class of ACE inhibitors used for lowering blood pressure. The risk of fluid retention and associated adverse effects on the heart are significantly increased when these medicines are used together.
Oxycodone:
Report the use of any opiate pain medicines to the doctor before receiving Pregabalin. Using these medicines together can cause severe dizziness, confusion, lack of coordination especially in the elderly and people with a history of emotional disturbances, suicidal thoughts, alcohol abuse, or drug abuse. Any such effect while using them together should be reported to the doctor.
Interaction with Disease:
Angioedema:
This medicine should be administered with caution in patients who have a history of or are at risk of developing swellings of the inner layers of the skin. These swellings can cause airway blockage and prove life-threatening.
Keep in a cool & dry place (below 30° C), protected from light & moisture. Keep out of the reach of children.
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