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Numira 5mg Tablet 1 Strip
Mirogabalin Besylate
- Neuropathic Pain
- Diabetic Peripheral Neuropathic Pain (DPNP)
- Postherpetic Neuralgia (PHN)
- Peripheral Neuropathic Pain (PNP)
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✅ Description:
Mirogabalin belongs to the class of gamma amino acids and their derivatives.
It selectively binds to the α2δ subunits of voltage-gated calcium channels (VGCCs). This reduces calcium influx and inhibits neurotransmitter release from presynaptic neurons, decreasing central nervous system (CNS) hyperexcitability.
- Rapid absorption after oral intake, with a time to maximum plasma concentration of 0.5-1.5 hours.
- Plasma protein binding is about 25%.
- Excretion: 99% via kidneys, 1% via feces.
Half-life: 2-4.9 hours.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration:
Adult Dose:
- Initial dose: 5 mg twice daily.
- Gradually increase by 5 mg each week up to 15 mg twice daily.
- Adjust dose between 10 mg and 15 mg twice daily depending on age and symptoms.
Use in Children and Adolescents: Safety and efficacy not established.
Hepatic Impairment: No significant adverse reactions for mild to moderate impairment. No data for severe hepatic impairment.
Renal Impairment:
- Mild: Start with 5 mg twice a day, increase to 10 mg.
- Moderate: Start with 2.5 mg twice a day, increase to 7.5 mg.
- Severe: Start with 2.5 mg once a day, increase to 7.5 mg.
✔️ Side Effects:
- Common: Somnolence, dizziness, edema, weight gain.
- Rare: Liver dysfunction (loss of appetite, jaundice, nausea), and loss of consciousness.
✔️ Interactions:
- With Medicines: Co-administration with Cimetidine or Probenecid may raise plasma concentration.
- CNS Depressive Effects: If combined with Lorazepam, may increase sedative effects.
- Drug Transporters: Numira is a substrate for several transporters; avoid using with inhibitors of OAT1, OAT3, OCT2, MATE1, MATE2-K, or UGT as it may increase exposure.
- Food & Alcohol: No clinically relevant effect with food. Avoid alcohol as it may increase sedative effects.
✔️ Contraindications:
- Hypersensitivity to Mirogabalin.
- Mild to moderate hepatic and renal impairment.
✔️ Pregnancy & Lactation:
- Pregnancy: Use only if the benefit outweighs risks.
- Lactation: May transfer into breast milk, consider the benefits of breastfeeding before discontinuation.
✔️ Precautions & Warnings:
- May cause dizziness, somnolence, or loss of consciousness. Avoid dangerous activities like driving.
- Can cause weight gain, blurred vision, and double vision.
- Elderly patients should be cautious of falling and fractures.
- Dose adjustment needed in patients with renal dysfunction.
- Consult with a doctor before using with other medications.
✔️ Storage:
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
