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Indications
Pregabalin is recommended for the treatment of post-herpetic neuralgia and neuropathic pain brought on by diabetic peripheral neuropathy. Additionally, it is approved as an adjunctive treatment for patients aged one month and older experiencing partial-onset seizures. It can be used to treat fibromyalgia and neuropathic pain brought on by spinal cord damage.
Pharmacology
Gamma-aminobutyric acid, an inhibitory neurotransmitter, is the structural basis of the drug pregabalin (GABA). It doesn't directly bind to benzodiazepine, GABAA, or GABAB receptors. It does not inhibit dopamine, serotonin, or noradrenaline reuptake and is inactive at dopamine and serotonin receptors. In the tissues of the central nervous system, prelica@ binds to the alpha 2 -delta site (an auxiliary subunit of voltage-gated calcium channels) with a high affinity. Prelica@'s oral bioavailability is 90% or higher and dose-independent. In subjects with normal renal function, it is primarily excreted from the body through the kidneys as an unchanged drug with a mean elimination half-life of 6.3 hours.
Dosage & Administration
Interaction
Pregabalin has no notable interactions with other antiepileptic medicines or oral contraceptives. Pregabalin has the potential to enhance the effects of ethanol and lorazepam.
Contraindications
Pregabalin is not recommended for individuals who have a history of hypersensitivity to Pregabalin or any of its components.
Side Effects
Common: Dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, and abnormal thinking.
Rare: Muscle weakness, muscle pain, breathing problems, diarrhea, etc.
Pregnancy & Lactation
Pregnancy: May cause fetal harm
Lactation: Breastfeeding is not recommended
Precautions & Warnings
Pregabalin withdrawal without tapering can result in insomnia, motion sickness, headaches, and diarrhea. Therefore, rather than stopping suddenly, it should be tapered gradually over a minimum of 1 week. Pregabalin treatment may cause an increase in creatinine kinase. If myopathy is identified or suspected, or if the level of creatinine kinase is noticeably elevated, it should be stopped right away.
Storage Condition
Do not store above 300C, protect from light & moisture Keep out of the reach of children
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.