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Sixtin 2.5mg Tablet is prescribed for the treatment of type-2 diabetes mellitus (T2DM) when diet and exercise alone are insufficient, and metformin cannot be administered due to contraindication or intolerance. In cases where diabetes is not adequately controlled by insulin or other oral antidiabetic medications (such as metformin, thiazolidinediones, or sulfonylureas), or a combination of these, saxagliptin can be included in a dual or triple medicine combination. It is used in conjunction with a balanced diet and regular exercise to enhance blood sugar control in adults with type 2 diabetes.
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✅ Description:
- Active Ingredient: Saxagliptin
- Drug Group: Anti-diabetic drugs
- Indication: Treatment of type 2 diabetes in adults (18 years and older) not controlled with one oral anti-diabetic medicine, diet, and exercise. Can be used alone or with other anti-diabetic medicines.
- Condition: Inadequate insulin production or ineffective insulin use.
- Symptoms: Increased thirst, urination, hunger, blurry vision, numbness in hands or feet, fatigue.
- Complementary Measures: Emphasize appropriate diet and exercise.
- Doctor's Advice: Follow advice on skin and foot care.
- Medical Conditions: Inform your doctor about serious kidney, liver, or heart problems, reduced immunity, type-1 diabetes, or pancreatic issues.
- Pregnancy and Breastfeeding: Not recommended; consult your doctor.
- Age Consideration: Not recommended for children and adolescents under 18 years.
- Worsening Symptoms: If any side effects worsen.
- Regular Check-ins: Follow up with your doctor for monitoring.
- Consistent Use: Take as directed by your healthcare provider.
- Follow-up: Regularly communicate with your doctor regarding any concerns.
Safety Advices
Alcohol
UNSAFE
Taking alcohol together with saxagliptin may affect blood glucose levels in patients with diabetes.
Pregnancy
CONSULT YOUR DOCTOR
Sixtin 2.5mg Tablet is not recommended for use by pregnant women. Consult your doctor before taking it.
Breastfeeding
CONSULT YOUR DOCTOR
Sixtin 2.5mg Tablet is not recommended for use by breastfeeding women as it is not known if it passes into human breast milk. Consult your doctor before taking it
Driving
CAUTION
Be cautious while driving or operating machinery.
Kidney
CONSULT YOUR DOCTOR
Sixtin 2.5mg Tablet is not recommended for use in patients with end-stage renal disease who are on hemodialysis. Sixtin 2.5mg Tablet should be used with caution in patients with reduced kidney function. Consult your doctor before taking it.
Liver
CONSULT YOUR DOCTOR
Sixtin 2.5mg Tablet is not recommended for use in patients with severe liver problems. Sixtin 2.5mg Tablet should be used with caution in patients with moderate liver disease. Consult your doctor before taking it.
Similar Products
✔️ Uses of Sixtin 2.5mg Tablet
- Treatment of Type 2 diabetes mellitus
✔️ How does Sixtin 2.5mg Tablet work?
Sixtin 2.5mg Tablet works by inhibiting Dipeptidyl Peptidaye-4 (DPP-4) enzyme activity and decreasing glucagon concentrations, thus increasing glucose-dependent insulin secretion from pancreatic beta cells.
✔️ Side Effects of Sixtin 2.5mg Tablet
- Common side effects include headache, nasopharyngitis, urinary tract infection, hypoglycemia (with insulin or sulfonylurea), and upper respiratory tract infection.
✔️ Quick Suggestions:
- Take Saxagliptin at the same time every day.
- Consistent timing helps establish a routine, making it easier to remember.
- Saxagliptin may have an impact on alertness or coordination.
- Saxagliptin may cause hypoglycemia, especially when:
- Used with other antidiabetic medicines.
- Consuming alcohol.
- Delaying or missing a meal.
- Carry sugary food or fruit juice to address hypoglycemia symptoms.
- Inform your doctor if you experience joint pains or symptoms like stomach pain, nausea, and/or vomiting.
- Timely reporting allows for monitoring and adjustment of the treatment plan if necessary.
✔️ Indications:
- Sixtin is used to treat type 2 diabetes mellitus.
- It is employed alongside a healthy diet and regular exercise to control blood sugar levels.
- Helps prevent serious complications of diabetes like kidney damage and blindness.
✔️ Pharmacology
- Saxagliptin inhibits dipeptidyl peptidase IV (DPP-IV), increasing active incretin levels.
- Raises glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), stimulating insulin production.
- Improves glycemic management in type 2 diabetes.
✔️ Dosage & Administration of Sixtin 2.5mg Tablet
- Recommended dosage: 2.5 mg or 5 mg once daily, regardless of meals.
- No dosage adjustment for mild renal impairment (CrCl >50 mL/min).
- For moderate or severe renal impairment or end-stage renal disease (CrCl ≤ 50 mL/min), the dosage is 2.5 mg once daily.
- Dosage may need adjustment with concomitant use of strong CYP3A4/5 inhibitors.
- Should be taken at the same time every day.
- Be cautious while driving or operating machinery.
- May cause hypoglycemia; carry sugary food in case of low blood sugar symptoms.
- Inform the doctor if joint pains or other symptoms occur.
✔️ Interaction
- Strong CYP3A4/5 inhibitors can interact.
- Interacts with antacids, corticosteroids, opioid pain killers, blood thinners, cholesterol-lowering medicines, anti-allergic drugs, and antianxiety drugs.
- Interaction with grapefruit juice and marijuana can affect the medication's effectiveness.
✔️ Contraindications
Diabetic ketoacidosis (a complication of type 1 diabetes).
✔️ Pregnancy & Lactation
Category B: No risk to the fetus shown in animal studies, but no controlled studies in pregnant women.
✔️ Precautions & Warnings
- Allergies, pregnancy, heart failure, and liver issues are highlighted.
- Symptoms of hypersensitivity reactions and pancreatitis should be monitored.
- Use with caution in renal impairment.
- Exercise caution during pregnancy and lactation.
✔️ Storage Conditions
Store between 20-25° C.
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